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N'-Nitro-D-arginine

Name: N'-Nitro-D-arginine
Brand: 2A Biotech
SKU: 2A-9046369

CAS Number66036-77-9

SynonymsMFCD00066013; N-ω-NITRO-L-ARGININE; (E)-N-[Amino(nitroamino)methylene]-D-ornithine; N'-Nitro-D-arginine; H-Arg(NO2)-OH; N-(N-Nitrocarbamimidoyl)-L-ornithine; H-D-Arg(NO2)-OH; Ng-Nitro-D-arginine

Molecular FormulaC6H13N5O4

Molecular Weight233.23 (free base basis)

Purity≥98 (HPLC)%

Density1.7±0.1 g/cm3

Boiling Point462.4±55.0 °C at 760 mmHg

Melting Point>220ºC

Appearancesolid

MSDSChinese English

Cat. No.: 2A-9046369 Purity: ≥98 (HPLC)%

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Quality Control of [ 66036-77-9 ] Purity: ≥98 (HPLC)% SDS Specification MoL

Chemical & Physical Properties
CAS Number	66036-77-9
Catalog No.	2A-9046369
Chinese Name	N'-硝基-D-精氨酸
Synonyms	MFCD00066013; N-ω-NITRO-L-ARGININE; (E)-N-[Amino(nitroamino)methylene]-D-ornithine; N'-Nitro-D-arginine; H-Arg(NO2)-OH; N-(N-Nitrocarbamimidoyl)-L-ornithine; H-D-Arg(NO2)-OH; Ng-Nitro-D-arginine
Molecular Formula	C6H13N5O4
Molecular Weight	233.23 (free base basis)
Purity	≥98 (HPLC)
Density	1.7±0.1 g/cm3
Boiling Point	462.4±55.0 °C at 760 mmHg
Melting Point	>220ºC
Appearance	solid
Storage Condition	Sealed in a cool, dry environment
Application	N'-nitro-D-arginine (NOLA) is a nitric oxide synthesis inhibitor and a vasodilator that relaxes smooth muscles, increases blood flow to the penis, and improves erections. N'-nitro-D-arginine also inhi
HTC	2925290090
PubChem ID	11111542
MDL Number	MFCD00039052
SMILES	[Cl-].[N+H3][C@@H](CCCN\C(=N\[N+](=O)[O-])\N)C(=O)OC
InChI	1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
InChI Key	QBNXAGZYLSRPJK-JEDNCBNOSA-N
NACRES Code	NA.77
UNSPSC	12352209
MSDS	msds/46369_1_66036_77_9.pdf
Bioactivity	N'-Nitro-D-arginine (NOLA), a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections. N'-Nitro-D-arginine also inhibits neutrophil migration by blocking receptors for tumour necrosis factor alpha (TNFα) and interleukin 8 (IL8) [1]. Related Catalog Research Areas >> Others Signaling Pathways >> Immunology/Inflammation >> NO Synthase In Vivo N'-Nitro-D-arginine (NOLA) (40 mg/ kg) produces a significant increase in systolic blood pressure in the chronic, awake, instrumented sheep model[1]. References [1]. C K Narkowicz, et al. Delayed recovery from NG-nitro-L-arginine in the conscious sheep. Clin Exp Pharmacol Physiol. 1991 Dec;18(12):843-6. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 462.4±55.0 °C at 760 mmHg Melting Point >220ºC Molecular Formula C6H13N5O4 Molecular Weight 219.199 Flash Point 233.5±31.5 °C Exact Mass 219.096756 PSA 157.05000 LogP -0.79 Vapour Pressure 0.0±2.4 mmHg at 25°C Index of Refraction 1.638 InChIKey MRAUNPAHJZDYCK-SCSAIBSYSA-N SMILES NC(=NCCCC(N)C(=O)O)N[N+](=O)[O-] Storage condition Store at RT.
Use of	N'-Nitro-D-arginine (NOLA), a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections. N'-Nitro-D-arginine also inhibits neutrophil migration by blocking receptors for tumour necrosis factor alpha (TNFα) and interleukin 8 (IL8) [1]. Properties Name (R)-2-Amino-5-(3-nitroguanidino)pentanoic acid Synonym More Synonyms H-D-Arg(NO2)-OH Biological Activity Description N'-Nitro-D-arginine (NOLA), a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections. N'-Nitro-D-arginine also inhibits neutrophil migration by blocking receptors for tumour necrosis factor alpha (TNFα) and interleukin 8 (IL8) [1]. Related Catalog Research Areas >> Others Signaling Pathways >> Immunology/Inflammation >> NO Synthase References [1]. C K Narkowicz, et al. Delayed recovery from NG-nitro-L-arginine in the conscious sheep. Clin Exp Pharmacol Physiol. 1991 Dec;18(12):843-6. Chemical & Physical Properties Molecular Formula C6H13N5O4 Exact Mass 219.096756 PSA 157.05000 LogP -0.79 Index of Refraction 1.638 InChIKey MRAUNPAHJZDYCK-SCSAIBSYSA-N SMILES NC(=NCCCC(N)C(=O)O)N[N+](=O)[O-] Storage condition Store at RT.
Tax Rebate	9.0%
Supervision	none
Transport Info	Product name: Summary 2925290090 other imines and their derivatives; salts thereof. Supervision conditions:None. VAT: 17.0%. Tax rebate rate:9.0%. MFN tariff: 6.5%. General tariff:30.0%

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N'-Nitro-D-arginine

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