CAS Number2306-27-6
Synonyms6-hydroxyluteolin 5,6,7,3',4'-pentamethyl ether; MFCD00017421; 3',4',5,6,7-PENTAMETHOXYFLAVONE; Sinensetin; 5,6,7,3',4'-pentamethoxyflavanone; 2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-chromen-4-one; Pedalitin permethyl ether; 5,6,7,3',4'-Pentamethoxyflavone; 2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one; Sinenstein
Molecular FormulaC20H20O7
Molecular Weight372.37
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point547.8±50.0 °C at 760 mmHg
Melting Point174-176ºC
AppearanceLight cream to yellow powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2306-27-6 |
| Catalog No. | 2A-9028293 |
| Chinese Name | 甜橙黄酮； 5,6,7,3',4'-五甲氧基黄酮 |
| Synonyms | 6-hydroxyluteolin 5,6,7,3',4'-pentamethyl ether; MFCD00017421; 3',4',5,6,7-PENTAMETHOXYFLAVONE; Sinensetin; 5,6,7,3',4'-pentamethoxyflavanone; 2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-chromen-4-one; Pedalitin permethyl ether; 5,6,7,3',4'-Pentamethoxyflavone; 2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one; Sinenstein |
| Molecular Formula | C20H20O7 |
| Molecular Weight | 372.37 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 547.8±50.0 °C at 760 mmHg |
| Melting Point | 174-176ºC |
| Appearance | Light cream to yellow powder |
| Storage Condition | 2-8°C |
| Application | Sinensetin is a methylated flavonoid found in fruits that has strong anti-vascular and anti-inflammatory properties. |
| HTC | 2914509090 |
| PubChem ID | 12372 |
| SMILES | COc1ccc(-c2cc(=O)c3c(OC)c(OC)c(OC)cc3o2)cc1OC |
| InChI | InChI=1S/C20H20O7/c1-22-13-7-6-11(8-15(13)23-2)14-9-12(21)18-16(27-14)10-17(24-3)19(25-4)20(18)26-5/h6-10H,1-5H3 |
| InChI Key | LKMNXYDUQXAUCZ-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.In vitro: Sinensetin promots adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels. [1] Sinensetin shows anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α). [2]In vivo: Sinensetin has the most potent antiangiogenesis activity and the lowest toxicity, inhibits angiogenesis by inducing cell cycle arrest in the G0/G1 phase in HUVEC culture and downregulating the mRNA expressions of angiogenesis genes flt1, kdrl, and hras in zebrafish. [3] Related Catalog Signaling Pathways >> Immunology/Inflammation >> PGE synthase Signaling Pathways >> Apoptosis >> TNF Receptor Natural Products >> Flavonoids Research Areas >> Others References [1]. Kang SI et al. Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes. Biol Pharm Bull. 2015;38(4):552-8. [2]. Shin HS et al. Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α. Biosci Biotechnol Biochem. 2012;76(4):847-9. [3]. Lam IK et al. In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. Mol Nutr Food Res. 2012 Jun;56(6):945-56. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 547.8±50.0 °C at 760 mmHg Melting Point 174-176ºC Molecular Formula C20H20O7 Molecular Weight 372.369 Flash Point 240.6±30.2 °C Exact Mass 372.120911 PSA 76.36000 LogP 3.08 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.566 InChIKey LKMNXYDUQXAUCZ-UHFFFAOYSA-N SMILES COc1ccc(-c2cc(=O)c3c(OC)c(OC)c(OC)cc3o2)cc1OC Storage condition 2-8°C |
| Use of | Properties Name sinensetin Synonym More Synonyms Sinensetin Biological Activity Related Catalog Signaling Pathways >> Immunology/Inflammation >> PGE synthase Signaling Pathways >> Apoptosis >> TNF Receptor Natural Products >> Flavonoids Research Areas >> Others References [1]. Kang SI et al. Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes. Biol Pharm Bull. 2015;38(4):552-8. [2]. Shin HS et al. Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α. Biosci Biotechnol Biochem. 2012;76(4):847-9. Chemical & Physical Properties Molecular Formula C20H20O7 Exact Mass 372.120911 PSA 76.36000 Index of Refraction 1.566 InChIKey LKMNXYDUQXAUCZ-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Sinensetin) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Sinensetin) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Sinensetin) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
| Related Products in Botanical Reference Standards | ||
|---|---|---|
| 18alpha-Glycyrrhetinic acid | 1449-05-4 | 2A-9026817 |
| Protopanaxatriol | 1453-93-6 | 2A-9026833 |
| Phenyl beta-D-glucopyranoside | 1464-44-4 | 2A-9026866 |
| 25-Hydroxycholesterol | 2140-46-7 | 2A-9028036 |
| Cucurbitacin I | 2222-07-3 | 2A-9028177 |
| Catalpol | 2415-24-9 | 2A-9028463 |
| Isochlorogenic acid A | 2450-53-5 | 2A-9028560 |
| 4-Nitrophenyl beta-D-glucopyranoside | 2492-87-7 | 2A-9028638 |
| 1,2-Benzanthraquinone | 2498-66-0 | 2A-9028647 |
| Allyl-beta-galactopyranoside | 2595-07-5 | 2A-9028792 |
| Browse all Botanical Reference Standards products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS