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25-Hydroxycholesterol structure, CAS 2140-46-7

25-Hydroxycholesterol

CAS Number2140-46-7

Synonyms25-Hydroxy Cholesterol; (3β,9β,14β)-Cholest-5-ene-3,25-diol

Molecular FormulaC27H46O2

Molecular Weight402.65

Purity98.00%

Density1.0±0.1 g/cm3

Boiling Point513.1±23.0 °C at 760 mmHg

Melting Point

Flash Point

Appearance

EINECS

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Cat. No.: 2A-9028036 Purity: 98.00%
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Quality Control of [ 2140-46-7 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number2140-46-7
Catalog No.2A-9028036
Chinese Name25-羟基胆固醇
Synonyms25-Hydroxy Cholesterol; (3β,9β,14β)-Cholest-5-ene-3,25-diol
Molecular FormulaC27H46O2
Molecular Weight402.65
Purity98.00
Density1.0±0.1 g/cm3
Boiling Point513.1±23.0 °C at 760 mmHg
Storage Condition2-8℃
Application25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-Hydroxycholesterol potently and selectively inh
PubChem ID629188
SMILESCC(CCCC(C)(C)O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C
InChIInChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1
InChI KeyINBGSXNNRGWLJU-ZHHJOTBYSA-N
Hazard Symbolstransportation
Bioactivity25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells. Related Catalog Research Areas >> Inflammation/Immunology Natural Products >> Steroids Target Human Endogenous Metabolite In Vitro The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems[1]. References [1]. McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 513.1±23.0 °C at 760 mmHg Molecular Formula C27H46O2 Molecular Weight 402.653 Flash Point 213.5±17.2 °C Exact Mass 402.349792 PSA 40.46000 LogP 7.66 Vapour Pressure 0.0±3.0 mmHg at 25°C Index of Refraction 1.538 InChIKey INBGSXNNRGWLJU-ZHHJOTBYSA-N SMILES CC(CCCC(C)(C)O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C Storage condition 2-8℃
Use of25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells. Properties Articles63 Name 25-hydroxycholesterol Synonym More Synonyms 25-Hydroxycholesterol Biological Activity Description 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells. Related Catalog Research Areas >> Inflammation/Immunology Natural Products >> Steroids Human Endogenous Metabolite In Vitro The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems[1]. References [1]. McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2. Chemical & Physical Properties Molecular Formula C27H46O2 Exact Mass 402.349792 PSA 40.46000 Index of Refraction 1.538 InChIKey INBGSXNNRGWLJU-ZHHJOTBYSA-N Storage condition 2-8℃
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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