CAS Number2415-24-9
SynonymsEINECS 219-324-0; catalpinoside; des-p-hydroxybenzoyl-catalposid; CATAPOL; catalposide; methyl iridoid glycoside
Molecular FormulaC15H22O10
Molecular Weight362.33
Purity98.00%
Density1.7±0.1 g/cm3
Boiling Point675.6±55.0 °C at 760 mmHg
Melting Point203-205ºC
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2415-24-9 |
| Catalog No. | 2A-9028463 |
| Chinese Name | 梓醇 |
| Synonyms | EINECS 219-324-0; catalpinoside; des-p-hydroxybenzoyl-catalposid; CATAPOL; catalposide; methyl iridoid glycoside |
| Molecular Formula | C15H22O10 |
| Molecular Weight | 362.33 |
| Purity | 98.00 |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 675.6±55.0 °C at 760 mmHg |
| Melting Point | 203-205ºC |
| Storage Condition | Keep container sealed, placed in a tight-fitting c |
| Application | Catalpol is an iridoid glycoside with neuroprotective, anti-inflammatory and antiviral hepatitis effects. |
| PubChem ID | 10224854 |
| SMILES | OCC1OC(OC2OC=CC3C(O)C4OC4(CO)C23)C(O)C(O)C1O |
| InChI | InChI=1S/C15H22O10/c16-3-6-9(19)10(20)11(21)14(23-6)24-13-7-5(1-2-22-13)8(18)12-15(7,4-17)25-12/h1-2,5-14,16-21H,3-4H2/t5-,6-,7-,8+,9-,10+,11-,12+,13+,14+,15-/m1/s1 |
| InChI Key | LHDWRKICQLTVDL-IZSBTIMLSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Catalpol, an iridoid glycoside, has neuroprotective, anti-inflammatory, and anti-hepatitis virus effects.IC50 Value:Target: neuroprotective, anti-inflammatory, and anti-hepatitis virus natural product.In vitro: Catalpol could be encapsulated into composite nanofibers and induce differentiation of hASCs into neural-like cells, which might offer new avenues in nerve regeneration [1].In vivo: The pharmacokinetics of catalpol in normal and doxorubicin-induced chronic kidney disease rats after oral administration of Rehmannia glutinosa extract was determined, and the extraction recoverie of catalpol was higher than 68.24% [2]. The protective effect of catalpol on renal IRI mice through suppressing phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt)-endothelial nitric oxide synthase (eNOS) and against inflammation, and the possible underlying mechanism [3]. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Terpenoids and Glycosides Research Areas >> Others References [1]. Zhao M, et al.Comparative pharmacokinetics of catalpol and acteoside in normal and chronic kidney disease rats after oral administration of Rehmannia glutinosa extract. Biomed Chromatogr. 2015 May 29. [2]. Guo JH, et al.Potential Neurogenesis of Human Adipose-Derived Stem Cells on Electrospun Catalpol-Loaded Composite Nanofibrous Scaffolds. Ann Biomed Eng. 2015 Mar 31. [3]. Zhu J,Catalpol protects mice against renal ischemia/reperfusion injury via suppressing PI3K/Akt-eNOS signaling and inflammation. Int J Clin Exp Med. 2015 Feb 15;8(2):2038-44. [4]. Xu Z, et al.Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose-induced hepatic mitochondrial dysfunction. Acta Biochim Biophys Sin (Shanghai). 2015 Jul 2. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 675.6±55.0 °C at 760 mmHg Melting Point 203-205ºC Molecular Formula C15H22O10 Molecular Weight 362.329 Flash Point 362.4±31.5 °C Exact Mass 362.121307 PSA 161.60000 LogP -4.15 Vapour Pressure 0.0±4.7 mmHg at 25°C Index of Refraction 1.679 InChIKey LHDWRKICQLTVDL-IZSBTIMLSA-N SMILES OCC1OC(OC2OC=CC3C(O)C4OC4(CO)C23)C(O)C(O)C1O Storage condition ?20°C |
| Use of | Catalpol, an iridoid glycoside, has neuroprotective, anti-inflammatory, and anti-hepatitis virus effects.IC50 Value:Target: neuroprotective, anti-inflammatory, and anti-hepatitis virus natural product.In vitro: Catalpol could be encapsulated into composite nanofibers and induce differentiation of hASCs into neural-like cells, which might offer new avenues in nerve regeneration [1].In vivo: The pharmacokinetics of catalpol in normal and doxorubicin-induced chronic kidney disease rats after oral administration of Rehmannia glutinosa extract was determined, and the extraction recoverie of catalpol was higher than 68.24% [2]. The protective effect of catalpol on renal IRI mice through suppressing phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt)-endothelial nitric oxide synthase (eNOS) and against inflammation, and the possible underlying mechanism [3]. Properties Articles26 Name Catalpol Synonym More Synonyms Catalpol Biological Activity Description Catalpol, an iridoid glycoside, has neuroprotective, anti-inflammatory, and anti-hepatitis virus effects.IC50 Value:Target: neuroprotective, anti-inflammatory, and anti-hepatitis virus natural product.In vitro: Catalpol could be encapsulated into composite nanofibers and induce differentiation of hASCs into neural-like cells, which might offer new avenues in nerve regeneration [1].In vivo: The pharmacokinetics of catalpol in normal and doxorubicin-induced chronic kidney disease rats after oral administration of Rehmannia glutinosa extract was determined, and the extraction recoverie of catalpol was higher than 68.24% [2]. The protective effect of catalpol on renal IRI mice through suppressing phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt)-endothelial nitric oxide synthase (eNOS) and against inflammation, and the possible underlying mechanism [3]. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Terpenoids and Glycosides Research Areas >> Others References [1]. Zhao M, et al.Comparative pharmacokinetics of catalpol and acteoside in normal and chronic kidney disease rats after oral administration of Rehmannia glutinosa extract. Biomed Chromatogr. 2015 May 29. [2]. Guo JH, et al.Potential Neurogenesis of Human Adipose-Derived Stem Cells on Electrospun Catalpol-Loaded Composite Nanofibrous Scaffolds. Ann Biomed Eng. 2015 Mar 31. [3]. Zhu J,Catalpol protects mice against renal ischemia/reperfusion injury via suppressing PI3K/Akt-eNOS signaling and inflammation. Int J Clin Exp Med. 2015 Feb 15;8(2):2038-44. [4]. Xu Z, et al.Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose-induced hepatic mitochondrial dysfunction. Acta Biochim Biophys Sin (Shanghai). 2015 Jul 2. Chemical & Physical Properties Molecular Formula C15H22O10 Exact Mass 362.121307 PSA 161.60000 LogP -4.15 Index of Refraction 1.679 InChIKey LHDWRKICQLTVDL-IZSBTIMLSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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