CAS Number31083-55-3
Synonyms2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione; 2-Pyridin-3-ylmethylene-indan-1,3-dione; 1,3-Dioxo-2-(3-pyridylmethylene)indan; 1,3-Indandione,2-(3-pyridylmethylene); 2-(3-Pyridylmethylen)-1,3-indandion; 2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione; 2-(3-Pyridylmethyliden)-indan-1,3-dion; 2-(3-Pyridylmethylene)-1,3-indandione; (E)-2-(pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione; Cannabigerol; NSC 600157; PRT4165
Molecular FormulaC15H9NO2
Molecular Weight235.24
Purity≥98 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point452.3±45.0 °C at 760 mmHg
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 31083-55-3 |
| Catalog No. | 2A-1198809 |
| Chinese Name | PRT4165 |
| Synonyms | 2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione; 2-Pyridin-3-ylmethylene-indan-1,3-dione; 1,3-Dioxo-2-(3-pyridylmethylene)indan; 1,3-Indandione,2-(3-pyridylmethylene); 2-(3-Pyridylmethylen)-1,3-indandion; 2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione; 2-(3-Pyridylmethyliden)-indan-1,3-dion; 2-(3-Pyridylmethylene)-1,3-indandione; (E)-2-(pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione; Cannabigerol; NSC 600157; PRT4165 |
| Molecular Formula | C15H9NO2 |
| Molecular Weight | 235.24 |
| Purity | ≥98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 452.3±45.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitination. |
| PubChem ID | 329825631 |
| MDL Number | MFCD00435709 |
| SMILES | O=C1C(C(C2=C1C=CC=C2)=O)=CC3=CN=CC=C3 |
| InChI | 1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H |
| InChI Key | OMHZFEWYVFWVLI-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/200751_1_31083_55_3.pdf |
| Bioactivity | PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme Research Areas >> Cancer Target PRC1[1] In Vitro PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation. In vitro E3 ubiquitin ligase activity assays reveal that PRT4165 inhibits both RNF2 and RING 1A, but not RNF8 nor RNF168. In the presence of PRT4165, H2A ubiquitylation could be completely inhibited regardless of whether RING1 or RNF2 contributes the E3 ubiquitin ligase activity. Treatment of cells for 60 min with 50 μM PRT4165 results in a dramatic reduction in total ubiquitylated histone H2A. It is also found that longer exposure of the cells with the PRT4165 (30 and 60 min) leads to increased levels of γ-H2AX in unirradiated cells. PRT4165 inhibits double-strand break (DSB) repair at the 8-h time point compare with mock treated cells. Cells treated with increasing concentrations of PRT4165 show increasing numbers of cells in G2/M[1]. Cell Assay Cells are treated with different concentrations of the PRT4165 60 min prior to irradiation (2 Gy). The cells are harvested 2 h after IR. The cells are washed with PBS twice and then fixed with 1% paraformaldehyde at 37°C for 10 min. After cooling on ice for 1 min, the cells are permeabilized with 90% methanol and stored at -20°C overnight. Fixed cells are washed with PBS twice and blocked with FACS incubation buffer (0.5% BSA in PBS) for 10 min. The cells are then stained with anti-phosphohistone H3 (serine 10) antibody at 1:500 dilution in FACS incubation buffer for 1 h at room temperature[1]. References [1]. Ismail IH, et al. A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks. J Biol Chem. 2013 Sep 13;288(37):26944-54. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 452.3±45.0 °C at 760 mmHg Molecular Formula C15H9NO2 Molecular Weight 235.238 Flash Point 227.0±35.1 °C Exact Mass 235.063324 PSA 47.03000 LogP 2.70 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.710 InChIKey OMHZFEWYVFWVLI-UHFFFAOYSA-N SMILES O=C1C(=Cc2cccnc2)C(=O)c2ccccc21 Storage condition -20℃ |
| Use of | PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation. Properties Name 2-(pyridin-3-ylmethylidene)indene-1,3-dione Synonym More Synonyms PRT 4165 Biological Activity Description PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation. Related Catalog Research Areas >> Cancer References [1]. Ismail IH, et al. A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks. J Biol Chem. 2013 Sep 13;288(37):26944-54. Chemical & Physical Properties Molecular Formula C15H9NO2 Exact Mass 235.063324 PSA 47.03000 Index of Refraction 1.710 InChIKey OMHZFEWYVFWVLI-UHFFFAOYSA-N Storage condition -20℃ |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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