CAS Number120-97-8
SynonymsDichlorophenamide; diclofenamide; diclofenamidum [INN_la]; MFCD00148948; 4,5-Dichlorobenzene-1,3-Disulfonamide; 4,5-Dichloro-1,3-benzenedisulfonamide; EINECS 204-440-6; Dichlorphenamide
Molecular FormulaC6H6N2Cl2O4S2
Molecular Weight305.16
Purity98.00%
Density1.8±0.1 g/cm3
Boiling Point590.5±60.0 °C at 760 mmHg
Melting Point239-241ºC
AppearanceWhite or almost white crystalline powder
EINECS204-440-6
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 120-97-8 |
| Catalog No. | 2A-9019104 |
| Chinese Name | 双氯非那胺 |
| Synonyms | Dichlorophenamide; diclofenamide; diclofenamidum [INN_la]; MFCD00148948; 4,5-Dichlorobenzene-1,3-Disulfonamide; 4,5-Dichloro-1,3-benzenedisulfonamide; EINECS 204-440-6; Dichlorphenamide |
| Molecular Formula | C6H6N2Cl2O4S2 |
| Molecular Weight | 305.16 |
| Purity | 98.00 |
| Density | 1.8±0.1 g/cm3 |
| Boiling Point | 590.5±60.0 °C at 760 mmHg |
| Melting Point | 239-241ºC |
| Appearance | White or almost white crystalline powder |
| Water Solubility | Water solubility: insoluble |
| Storage Condition | Store in inert gas; avoid air |
| Application | Dichlorphenamide (Diclofenamide) is a carbonic anhydrase inhibitor. |
| EINECS | 204-440-6 |
| HTC | 2935009090 |
| PubChem ID | 329749374 |
| MDL Number | MFCD00148948 |
| SMILES | NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O |
| InChI | 1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) |
| InChI Key | GJQPMPFPNINLKP-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/19104_1_120_97_8.pdf |
| Use of | Properties Name diclofenamide Synonym More Synonyms diclofenamide Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Research Areas >> Neurological Disease References [1]. Kanski, J.J., Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors. Br J Ophthalmol, 1968. 52(8): p. 642-3. [2]. Rucquoy, M. and L. Sorel, Diclofenamide in the treatment of therapy-resistant epilepsy. Acta Neurol Belg, 1978. 78(3): p. 174-82. Chemical & Physical Properties Exact Mass 303.914612 PSA 137.08000 Index of Refraction 1.635 InChIKey GJQPMPFPNINLKP-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : m-Benzenedisulfonamide, 4,5-dichloro- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C6-H6-Cl2-N2-O4-S2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : ZSWR BG CG ESZW HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,446,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,446,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,41,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 19,1423,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,41,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,41,1969 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 1-22 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 11,31,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SEX/DURATION : female 15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - eye/ear REFERENCE : DEBIAO Developmental Biology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 27,395,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SEX/DURATION : female 13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - eye/ear REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 4,239,1971 Safety Information Hazard Codes Xn: Harmful; Risk Phrases R63 Safety Phrases S36 RIDADR NONH for all modes of transport RTECS CZ9200000 HS Code 2935009090 Synthetic Route Total: 1 Page 4,5-Dichloro-1,... CAS#:70269-54-4 diclofenamide CAS#:120-97-8 Literature: US2835702 , ; Precursor & DownStream Precursor 1 CAS#:70269-54-4 4,5-Dichloro-1,... DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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