CAS Number120-46-7
Synonyms1,3-Diphenyl-1,3-propanedione; 1,3-diphenylpropane-1,3-dione; Dibenzoylmethane; MFCD00003085; phenacyl phenyl ketone; EINECS 204-398-9
Molecular Formula(C6H5CO)2CH2
Molecular Weight224.25
Purity98%
Density1.1±0.1 g/cm3
Boiling Point219-221 °C/18 mmHg (lit.)
Melting Point77-79 °C (lit.)
Appearancecrystals
EINECS204-398-9
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 120-46-7 |
| Catalog No. | 2A-9019085 |
| Chinese Name | 二苯甲酰甲烷 |
| Synonyms | 1,3-Diphenyl-1,3-propanedione; 1,3-diphenylpropane-1,3-dione; Dibenzoylmethane; MFCD00003085; phenacyl phenyl ketone; EINECS 204-398-9 |
| Molecular Formula | (C6H5CO)2CH2 |
| Molecular Weight | 224.25 |
| Purity | 98 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 219-221 °C/18 mmHg (lit.) |
| Melting Point | 77-79 °C (lit.) |
| Appearance | crystals |
| Storage Condition | Store sealed in a cool, dry place. Make sure the w |
| Application | Dibenzoylmethane, a minor component in licorice, activates Nrf2 and protects against various cancers and oxidative damage. Dibenzoylmethane is an analogue of curcumin that causes Keap1 dissociation an |
| EINECS | 204-398-9 |
| HTC | 2914399090 |
| PubChem ID | 24893746 |
| MDL Number | MFCD00003085 |
| SMILES | O=C(CC(=O)c1ccccc1)c2ccccc2 |
| InChI | 1S/C15H12O2/c16-14(12-7-3-1-4-8-12)11-15(17)13-9-5-2-6-10-13/h1-10H,11H2 |
| InChI Key | NZZIMKJIVMHWJC-UHFFFAOYSA-N |
| Beilstein/REAXYS | 514910 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| MSDS | msds/19085_1_120_46_7.pdf |
| Bioactivity | Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Metabolic Disease In Vitro Dibenzoylmethane (10, 20, 30, 40, 50 μM; 6 hours) treatment concentration-dependently increases the mRNA level of HO-1 but has no effect on the mRNA level of Nrf2 in HepG2 cells. Dibenzoylmethane induces HO-1 and Nrf2 protein expression, and the induction diminishes after 12 h[1]. Dibenzoylmethane (10, 20, 30, 40, 50 μM; 2 hours) concentration-dependently increases the phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells.Dibenzoylmethane does not show significant cytotoxicity[1]. In Vivo Dibenzoylmethane (200, 500 mg/kg/day; ip; for three consecutive days) pretreatment significantly reduces both the area and the severity of necrosis, as well as the leukocyte infiltration, at a dose of 200 mg/kg in wild-type and Nrf2 knockout mice[1]. Dibenzoylmethane protectes against CCl4-induced (1:49,v/v, 10 ml/kg) liver damage in wild-type mice[1]. References [1]. Mingnan Cao, et al. Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling. AAPS J. 2017 Nov;19(6):1703-1714. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 357.4±0.0 °C at 760 mmHg Melting Point 77-79 °C(lit.) Molecular Formula C15H12O2 Molecular Weight 224.255 Flash Point 146.9±20.2 °C Exact Mass 224.083725 PSA 34.14000 LogP 3.04 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.584 InChIKey NZZIMKJIVMHWJC-UHFFFAOYSA-N SMILES O=C(CC(=O)c1ccccc1)c1ccccc1 Storage condition Store at RT. Stability Stable. Incompatible with strong oxidizing agents. |
| Use of | Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2[1]. Properties Articles29 Name dibenzoylmethane Synonym More Synonyms 1,3-Diphenylpropane-1,3-dione Biological Activity Description Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Metabolic Disease References [1]. Mingnan Cao, et al. Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling. AAPS J. 2017 Nov;19(6):1703-1714. Chemical & Physical Properties Molecular Formula C15H12O2 Exact Mass 224.083725 PSA 34.14000 Index of Refraction 1.584 InChIKey NZZIMKJIVMHWJC-UHFFFAOYSA-N Storage condition Store at RT. Stability Stable. Incompatible with strong oxidizing agents. |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 5.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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