CAS Number5817-39-0
Synonyms(S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid; 3,3',5'-Triiodo-L-thyronine; Reverse triiodothyronine; REVERSE T3; O-(4-Hydroxy-3,5-diiodophenyl)-3-iodotyrosine
Molecular FormulaC15H12I3NO4
Molecular Weight650.97
Density2.4±0.1 g/cm3
Boiling Point534.6±50.0 °C at 760 mmHg
Melting Point234-238ºC(lit.)
Appearanceliquid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5817-39-0 |
| Catalog No. | 2A-3177840 |
| Chinese Name | 3,3',5'-三碘-L-甲状腺原氨酸 |
| Synonyms | (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid; 3,3',5'-Triiodo-L-thyronine; Reverse triiodothyronine; REVERSE T3; O-(4-Hydroxy-3,5-diiodophenyl)-3-iodotyrosine |
| Molecular Formula | C15H12I3NO4 |
| Molecular Weight | 650.97 |
| Density | 2.4±0.1 g/cm3 |
| Boiling Point | 534.6±50.0 °C at 760 mmHg |
| Melting Point | 234-238ºC(lit.) |
| Appearance | liquid |
| Storage Condition | 2-8°C |
| Application | Reverse T3 is a thyroid hormone produced by deiodination of prothyroxine [1]. T3 reversal inhibits the increase in sodium current produced by other thyroid hormone analogues in neonatal rat cardiomyoc |
| HTC | 2922509090 |
| PubChem ID | 329826619 |
| MDL Number | MFCD00036864 |
| SMILES | N[C@@H](Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O |
| InChI | 1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1 |
| InChI Key | HZCBWYNLGPIQRK-LBPRGKRZSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/178442_1_5817_39_0.pdf |
| Use of | Reverse T3 is a thyroid hormone generated by deiodination of the prohormone thyroxine[1]. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes[2]. Properties Articles34 Name 3,3',5'-triiodothyronine Synonym More Synonyms 3,3',5'-triiodothyronine Biological Activity Description Reverse T3 is a thyroid hormone generated by deiodination of the prohormone thyroxine[1]. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes[2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Thyroid Hormone Receptor References [1]. Nicod P, et al. Radioimmunoassay for 3,3',5'-triiodo-L-thyronine in unextracted serum: method and clinical results. J Clin Endocrinol Metab. 1976 May;42(5):823-9. [2]. Rebolledo RA, et al. Anti-Apoptotic Effects of 3,3',5-Triiodo-L-Thyronine in the Liver of Brain-Dead Rats. PLoS One. 2015 Oct 5;10(10):e0138749. Chemical & Physical Properties Molecular Formula C15H12I3NO4 Exact Mass 650.790039 PSA 92.78000 Index of Refraction 1.763 InChIKey HZCBWYNLGPIQRK-LBPRGKRZSA-N Safety Information GHS02, GHS06, GHS08 Signal Word Danger Hazard Statements H225-H301 + H311 + H331-H370 Precautionary Statements P210-P260-P280-P301 + P310 + P330-P302 + P352 + P312-P370 + P378 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xn: Harmful; Safety Phrases 36 RIDADR UN1230 - class 3 - PG 2 - Methanol, solution WGK Germany 3 RTECS AY6750000 HS Code 2922509090 Synthetic Route L-thyroxine CAS#:51-48-9 3,3',5'-triiodo... CAS#:5817-39-0 Literature: European Journal of Clinical Pharmacology, , vol. 55, # 11-12 p. 807 - 814 3-iodo-l-thyronine CAS#:10468-90-3 3,3',5'-triiodo... CAS#:5817-39-0 Literature: Journal of Medicinal Chemistry, , vol. 19, # 8 p. 1067 - 1069 (2S)-2-acetamid... CAS#:1023-47-8 3,3',5'-triiodo... CAS#:5817-39-0 Literature: Journal of Medicinal Chemistry, , vol. 19, # 8 p. 1067 - 1069 |
| Tax Rebate | 13.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Supervision conditions A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
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