CAS Number67-30-1
Synonyms5-diiodophenoxy)-3; Thyroacetic acid,3,3',5,5'-tetraiodo; 3,5-Diiodo-4-(4-hydroxy-3,5-diiodophenoxy)benzeneacetic acid; Tetrac; MFCD00055932; [4-(4-hydroxy-3; 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic acid; Benzeneacetic acid,3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy); 3,3',5,5'-TETRAIODOTHYROACETIC ACID; Tetraiodothyroacetic acid; Acide 3,5,3',5'-tetraiodothyroacetique [French]; 5-diiodophenyl] acetic acid; EINECS 200-649-1
Molecular FormulaC14H8O4I4
Molecular Weight747.83
Density2.727g/cm3
Boiling Point544.8ºC at 760 mmHg
Melting Point230 °C
AppearanceSolid;White to Yellow to Green powder to crystal
EINECS200-649-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 67-30-1 |
| Catalog No. | 2A-3177842 |
| Chinese Name | 3,3',5,5'-四碘甲腺-乙酸 |
| Synonyms | 5-diiodophenoxy)-3; Thyroacetic acid,3,3',5,5'-tetraiodo; 3,5-Diiodo-4-(4-hydroxy-3,5-diiodophenoxy)benzeneacetic acid; Tetrac; MFCD00055932; [4-(4-hydroxy-3; 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic acid; Benzeneacetic acid,3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy); 3,3',5,5'-TETRAIODOTHYROACETIC ACID; Tetraiodothyroacetic acid; Acide 3,5,3',5'-tetraiodothyroacetique [French]; 5-diiodophenyl] acetic acid; EINECS 200-649-1 |
| Molecular Formula | C14H8O4I4 |
| Molecular Weight | 747.83 |
| Density | 2.727g/cm3 |
| Boiling Point | 544.8ºC at 760 mmHg |
| Melting Point | 230 °C |
| Appearance | Solid;White to Yellow to Green powder to crystal |
| Storage Condition | <0°C; avoid heating |
| Application | Tetrac (Tetraiodothyroacetic acid), a deaminated analog of L-thyroxine (T4), is a thyroxine integrin receptor antagonist. Tetrac blocks the effects of T3 and T4 as well as angiogenesis mediated by dif |
| EINECS | 200-649-1 |
| HTC | 2918990090 |
| PubChem ID | 24900169 |
| MDL Number | MFCD00055932 |
| SMILES | OC(=O)Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1 |
| InChI | 1S/C14H8I4O4/c15-8-4-7(5-9(16)13(8)21)22-14-10(17)1-6(2-11(14)18)3-12(19)20/h1-2,4-5,21H,3H2,(H,19,20) |
| InChI Key | PPJYSSNKSXAVDB-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352106 |
| Hazard Symbols | 6.1 |
| MSDS | msds/178444_1_67_30_1.pdf |
| Use of | Tetrac (Tetraiodothyroacetic acid), a deaminated analogue of L-thyroxine (T4), and is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T3 and T4 as well as different growth factors-mediated angiogenesis. Tetra also has anticancer activity[1][2]. Properties Articles28 Name 2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]acetic acid Synonym More Synonyms Tetrac Biological Activity Description Tetrac (Tetraiodothyroacetic acid), a deaminated analogue of L-thyroxine (T4), and is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T3 and T4 as well as different growth factors-mediated angiogenesis. Tetra also has anticancer activity[1][2]. Related Catalog Research Areas >> Cancer References [1]. Schmohl KA, et, al. Tetrac as an anti-angiogenic agent in cancer. Endocr Relat Cancer. 2019 Jun 1; 26(6):R287-R304. [2]. Davis PJ, et, al. Nongenomic Actions of Thyroid Hormone: the Integrin Component. Physiol Rev. 2020 Jun 25. [3]. Chin YT, et, al. Tetrac and NDAT Induce Anti-proliferation via Integrin αvβ3 in Colorectal Cancers With Different K-RAS Status. Front Endocrinol (Lausanne). 2019 Mar 12; 10:130. [4]. Ashur-Fabian O, et, al. Tetrac Delayed the Onset of Ocular Melanoma in an Orthotopic Mouse Model. Front Endocrinol (Lausanne). 2019 Jan 8; 9:775. [5]. Rajabi M, et, al. Synthesis of new analogs of tetraiodothyroacetic acid (tetrac) as novel angiogenesis inhibitors for treatment of cancer. Bioorg Med Chem Lett. 2018 Apr 15;28(7):1223-1227. Chemical & Physical Properties Molecular Formula C14H8I4O4 Exact Mass 747.66000 PSA 66.76000 LogP 5.23000 Index of Refraction 1.801 InChIKey PPJYSSNKSXAVDB-UHFFFAOYSA-N Safety Information Signal Word Danger Hazard Statements H300 Precautionary Statements P264-P301 + P310 Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges Hazard Codes T+ Risk Phrases 28 Safety Phrases 45 RTECS CY1585800 Hazard Class 6.1 HS Code 2918990090 Synthetic Route 3,5-Diiodothyro... CAS#:1155-40-4 CAS#:67-30-1 Literature: Bridoux, Alexandre; Khan, Riaz A.; Chen, Celei; Cheve, Gwenael; Cui, Huadong; Dyskin, Evgeny; Yasri, Aziz; Mousa, Shaker A. Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 6 p. 871 - 882 (4-hydroxy-3,5-... CAS#:83799-60-4 CAS#:67-30-1 [4-(4-methoxy-p... CAS#:861065-72-7 CAS#:67-30-1 Precursor & DownStream Precursor 8 CAS#:1155-40-4 3,5-Diiodothyro... CAS#:83799-60-4 (4-hydroxy-3,5-... CAS#:861065-72-7 [4-(4-methoxy-p... CAS#:150-76-5 DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| Related Products in Analytical Standards | ||
|---|---|---|
| Lercanidipine Dimethyl ester impurity oxalate salt | 957214-95-8 | 2A-3177833 |
| Levobupivacaine Impurity C | 1797894-80-4 | 2A-3177836 |
| Levothyroxine EP Impurity H | 2055-97-2 | 2A-3177838 |
| Levothyroxine EP Impurity I | 2016-06-0 | 2A-3177839 |
| Levothyroxine EP Impurity K | 5817-39-0 | 2A-3177840 |
| Linagliptin impurity N | 2A-3177845 | 2A-3177845 |
| Linagliptin Impurity V | 2A-3177846 | 2A-3177846 |
| Linagliptin Impurity P | 2A-3177847 | 2A-3177847 |
| Linagliptin Impurity Y | 2A-3177848 | 2A-3177848 |
| Linagliptin Impurity R | 2A-3177849 | 2A-3177849 |
| Browse all Analytical Standards products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS