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K-252A structure, CAS 99533-80-9

K-252A

CAS Number99533-80-9

Synonymsantibiotick252a; K252a; K-252A,NOCARDIOPSIS SP; K-252a; antibioticsf2370; sf2370

Molecular FormulaC27H21N3O5

Molecular Weight467.47

Purity>98%

Density1.7±0.1 g/cm3

Boiling Point685.3±55.0 °C at 760 mmHg

Melting Point

Flash Point

Appearancesolution

EINECS200-664-3

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-1177757 Purity: >98%
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Quality Control of [ 99533-80-9 ] Purity: >98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number99533-80-9
Catalog No.2A-1177757
Chinese Name(+)-抗生素 K 252A
Synonymsantibiotick252a; K252a; K-252A,NOCARDIOPSIS SP; K-252a; antibioticsf2370; sf2370
Molecular FormulaC27H21N3O5
Molecular Weight467.47
Purity>98
Density1.7±0.1 g/cm3
Boiling Point685.3±55.0 °C at 760 mmHg
Appearancesolution
Storage Condition-20°C, sealed, dry
ApplicationK-252a is an analogue of staurosporine that can be isolated from the soil fungus Nocardiopsis sp. and is an inhibitor of protein kinases. The IC50 values ​​for PKC, PKA, type II calmodulin-dependent k
EINECS200-664-3
PubChem ID329817131
MDL NumberMFCD00161522
SMILES[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
InChI1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
InChI KeyKOZFSFOOLUUIGY-SOLYNIJKSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard Symbolstransportation
MSDSmsds/178347_1_99533_80_9.pdf
BioactivityK-252a, a staurosporine analog isolated from Nocardiopsis sp. soil fungi, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively[1][2]. Related Catalog Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Neuronal Signaling >> CaMK Research Areas >> Infection Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Signaling Pathways >> TGF-beta/Smad >> PKC Target IC50: 470 nM (PKC), 140 nM (PKA), 270 nM (Ca2+/calmodulin-dependent kinase type II), 1.7 nM (phosphorylase kinase)[1][2]. References [1]. Yasuzawa, T., et al. The structures of the novel protein kinase C inhibitors K-252a, b, c AND d Journal of Antibiotics 39(8), 1072-1078 (1986). [2]. Davis, P.D., et al. Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimides Journal of Medicinal Chemistry 35, 177-184 (1992). Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 685.3±55.0 °C at 760 mmHg Molecular Formula C27H21N3O5 Molecular Weight 467.473 Flash Point 368.2±31.5 °C Exact Mass 467.148132 PSA 94.72000 LogP 4.23 Vapour Pressure 0.0±2.2 mmHg at 25°C Index of Refraction 1.841 InChIKey KOZFSFOOLUUIGY-SOLYNIJKSA-N SMILES COC(=O)C1(O)CC2OC1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
Use ofK-252a, a staurosporine analog isolated from Nocardiopsis sp. soil fungi, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively[1][2]. Properties Articles19 Name K-252a Synonym More Synonyms K-252a Biological Activity Description K-252a, a staurosporine analog isolated from Nocardiopsis sp. soil fungi, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively[1][2]. Related Catalog Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Neuronal Signaling >> CaMK Research Areas >> Infection Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Signaling Pathways >> TGF-beta/Smad >> PKC IC50: 470 nM (PKC), 140 nM (PKA), 270 nM (Ca2+/calmodulin-dependent kinase type II), 1.7 nM (phosphorylase kinase)[1][2]. References [2]. Davis, P.D., et al. Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimides Journal of Medicinal Chemistry 35, 177-184 (1992). Chemical & Physical Properties Molecular Formula C27H21N3O5 Exact Mass 467.148132 PSA 94.72000 Index of Refraction 1.841 InChIKey KOZFSFOOLUUIGY-SOLYNIJKSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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