| Chemical & Physical Properties | |
|---|---|
| CAS Number | 85753-43-1 |
| Catalog No. | 2A-1177759 |
| Chinese Name | K-252c |
| Synonyms | staurosporine aglycon; Staurosporinone; STAUROSPORINE AGLYCONE |
| Molecular Formula | C20H13N3O |
| Molecular Weight | 311.34 |
| Purity | ≥95 (HPLC) |
| Appearance | solid |
| Storage Condition | -20°C, sealed, dry |
| Application | K-252c, a staurosporine analogue isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor with an IC50 value of 2.45 µM. K-252c can induce apoptosis in human chronic myeloid leukemia cancer c |
| HTC | 2933990090 |
| MDL Number | MFCD00236435 |
| SMILES | [nH]1c2c3[nH]c4c(c3c5c(c2c6c1cccc6)CNC5=O)cccc4 |
| InChI | 1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24) |
| InChI Key | MEXUTNIFSHFQRG-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/178349_1_85753_43_1.pdf |
| Use of | Properties Synonym More Synonyms Related Catalog Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Anti-infection >> Bacterial IC50: 2.45 µM (PKC)[1]. References [1]. Pereira, E.R., et al. Structure-activity relationships in a series of substituted indolocarbazoles: Topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties J. Med. Chem. 39(22), 4471-4477 (1996). [2]. Liu, R., et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z2039-2 Arch. Pharm. Res. 30(3), 270-274 (2007). [3]. Zimmermann, A., et al. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase Antiviral Res. 48(1), 49-60 (2000). [4]. McGovern, S.L., et al. Kinase inhibitors: Not just for kinases anymore Journal of Medicinal Chemistry 46, 1478-1483 (2003). Chemical & Physical Properties Molecular Formula C20H13N3O Exact Mass 311.10600 PSA 60.68000 LogP 4.52780 InChIKey MEXUTNIFSHFQRG-UHFFFAOYSA-N Safety Information WGK Germany 3 HS Code 2933990090 Synthetic Route Arcyriaflavin A 118458-54-1 85753-43-1 Literature: Yang, Shyh-Ming; Malaviya, Ravi; Wilson, Lawrence J.; Argentieri, Rochelle; Chen, Xin; Yang, Cangming; Wang, Bingbing; Cavender, Druie; Murray, William V. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 2 p. 326 - 331 12-benzyl-6-(2,... 934506-88-4 85753-43-1 Literature: Wada, Yasuhiro; Nagasaki, Hideo; Tokuda, Masao; Orito, Kazuhiko Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 2008 - 2014 934506-87-3 85753-43-1 Literature: Wada, Yasuhiro; Nagasaki, Hideo; Tokuda, Masao; Orito, Kazuhiko Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 2008 - 2014 Precursor & DownStream Precursor 3 CAS#:118458-54-1 Arcyriaflavin A CAS#:51925-58-7 4-diazonio-3-ox... CAS#:40899-99-8 1H,1'H-2,2'-Biindole DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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