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KT5823 structure, CAS 126643-37-6

KT5823

CAS Number126643-37-6

SynonymsMFCD00132119

Molecular FormulaC29H25N3O5

Molecular Weight495.53

Purity≥98 (HPLC)%

Density1.52g/cm3

Boiling Point629.2ºC at 760mmHg

Melting Point

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-1177761 Purity: ≥98 (HPLC)%
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Quality Control of [ 126643-37-6 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number126643-37-6
Catalog No.2A-1177761
Chinese Name蛋白激酶仰制剂KT5823
SynonymsMFCD00132119
Molecular FormulaC29H25N3O5
Molecular Weight495.53
Purity≥98 (HPLC)
Density1.52g/cm3
Boiling Point629.2ºC at 760mmHg
Appearancesolid
Storage ConditionSealed, store at 2 ºC -8 ºC
ApplicationKT5823 is a selective cGMP-dependent protein kinase (PKG) inhibitor with a Ki of 0.23 μM. KT5823 also inhibits PKA and PKC with Ki of 10 μM and 4 μM, respectively. KT5823 is a staurosporine-related pr
MDL NumberMFCD09878278
SMILES[n]21c3c4[n](c6c(c4c7c(c3c8c2cccc8)CN(C7=O)C)cccc6)[C@@H]5O[C@]1([C@@](C5)(OC)C(=O)OC)C
InChI1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1
InChI KeyQTYMDECKVKSGSM-YMUMJAELSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard Symbolstransportation
MSDSmsds/178351_1_126643_37_6.pdf
BioactivityKT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 μM, it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively[1]. KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression, and iodide uptake in thyroid cells[2]. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation[3]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Research Areas >> Others Signaling Pathways >> Stem Cell/Wnt >> PKA Signaling Pathways >> TGF-beta/Smad >> PKC Target PKA:10 μM (Ki) PKC:4 μM (Ki) References [1]. 1.Gadbois DM, et al. Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8626-30. [2]. Wyatt TA, et al. KT5823 activates human neutrophils and fails to inhibit cGMP-dependent protein kinase phosphorylation of vimentin. Res Commun Chem Pathol Pharmacol. 1991 Oct;74(1):3-14. [3]. Chan SL, et al. Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. Mol Hum Reprod. 2003 Dec;9(12):775-83. Chemical & Physical Properties Density 1.52g/cm3 Boiling Point 629.2ºC at 760mmHg Molecular Formula C29H25N3O5 Molecular Weight 495.52600 Flash Point 334.3ºC Exact Mass 495.17900 PSA 74.93000 LogP 4.58930 Vapour Pressure 9.67E-16mmHg at 25°C Index of Refraction 1.763 InChIKey QTYMDECKVKSGSM-YMUMJAELSA-N SMILES COC(=O)C1(OC)CC2OC1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N(C)C4
Use ofProperties Articles32 Name kt 5823 Synonym More Synonyms KT5823 Biological Activity Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Research Areas >> Others Signaling Pathways >> Stem Cell/Wnt >> PKA Signaling Pathways >> TGF-beta/Smad >> PKC PKA:10 μM (Ki) PKC:4 μM (Ki) References [1]. 1.Gadbois DM, et al. Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8626-30. [2]. Wyatt TA, et al. KT5823 activates human neutrophils and fails to inhibit cGMP-dependent protein kinase phosphorylation of vimentin. Res Commun Chem Pathol Pharmacol. 1991 Oct;74(1):3-14. [3]. Chan SL, et al. Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. Mol Hum Reprod. 2003 Dec;9(12):775-83. Chemical & Physical Properties Molecular Formula C29H25N3O5 Exact Mass 495.17900 PSA 74.93000 LogP 4.58930 Index of Refraction 1.763 InChIKey QTYMDECKVKSGSM-YMUMJAELSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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