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CYTOCHALASIN A structure, CAS 14110-64-6

CYTOCHALASIN A

CAS Number14110-64-6

Synonymscytochalasin a from helminthosporium dematioideum; MFCD00005935; 20-dehydro-phomin; 7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-triene-1,20,23-trione; CytochalasinA from Drechslera dematioidea; Cytochalasin A; Dehydrophomin; EINECS 237-964-9; Cytochalasin dreschslera dematioidea; 5,5-Didehydrophomin

Molecular FormulaC29H35NO5

Molecular Weight507.62

Purity≥98 (TLC)%

Density1.2±0.1 g/cm3

Boiling Point725.1±60.0 °C at 760 mmHg

Melting Point147 to 148'ºC

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

Symbol6.1(a)

Signal WordWarning

Cat. No.: 2A-1177710 Purity: ≥98 (TLC)%
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Quality Control of [ 14110-64-6 ] Purity: ≥98 (TLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number14110-64-6
Catalog No.2A-1177710
Chinese Name细胞松弛素A
Synonymscytochalasin a from helminthosporium dematioideum; MFCD00005935; 20-dehydro-phomin; 7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-triene-1,20,23-trione; CytochalasinA from Drechslera dematioidea; Cytochalasin A; Dehydrophomin; EINECS 237-964-9; Cytochalasin dreschslera dematioidea; 5,5-Didehydrophomin
Molecular FormulaC29H35NO5
Molecular Weight507.62
Purity≥98 (TLC)
Density1.2±0.1 g/cm3
Boiling Point725.1±60.0 °C at 760 mmHg
Melting Point147 to 148'ºC
Appearancesolid
Water Solubilityethanol: 20 mg/mL, clear, colorless | Soluble in D
Storage Condition−20°C
PackagingI
ApplicationCytochalasin A is a cell-permeable mycotoxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM), inhibits actin polymerization, and interfer
HTC29349990
MDL NumberMFCD00077706
SMILESN1[C@H]([C@H]3[C@]4([C@H]([C@@H](C(=C)[C@H]3C)O)\C=C\C[C@@H](C(=O)[C@@](\C=C\[C@H]4OC(=O)C)(O)C)C)C1=O)Cc2ccccc2
InChI1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1
InChI KeySDZRWUKZFQQKKV-JHADDHBZSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard Symbols6.1(a)
BioactivityCytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives[1][2]. Related Catalog Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease Target HIV-1 protease[1] References [1]. Kerman K, et al. An electrochemical approach for the detection of HIV-1 protease. Chem Commun (Camb). 2007 Oct 7;(37):3829-31. [2]. Antonio Bottalico, et al. Cytochalasins: Structure-activity relationships. Phytochemistry Volume 29, Issue 1, 1990. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 725.1±60.0 °C at 760 mmHg Melting Point 147 to 148'ºC Molecular Formula C29H35NO5 Molecular Weight 477.592 Flash Point 392.3±32.9 °C Exact Mass 477.251526 PSA 92.70000 LogP 2.83 Vapour Pressure 0.0±2.5 mmHg at 25°C Index of Refraction 1.590 InChIKey ZMAODHOXRBLOQO-TZVKRXPSSA-N SMILES C=C1C(C)C2C(Cc3ccccc3)NC(=O)C23OC(=O)C=CC(=O)CCCC(C)CC=CC3C1O Storage condition −20°C Water Solubility ethanol: 20 mg/mL, clear, colorless | Soluble in DMF, DMSO, ethanol and acetone. Insoluble in water.
Use ofCytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives[1][2]. Properties Articles25 Name cytochalasin a Synonym More Synonyms Cytochalasin A Biological Activity Description Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives[1][2]. Related Catalog Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease HIV-1 protease[1] References [1]. Kerman K, et al. An electrochemical approach for the detection of HIV-1 protease. Chem Commun (Camb). 2007 Oct 7;(37):3829-31. [2]. Antonio Bottalico, et al. Cytochalasins: Structure-activity relationships. Phytochemistry Volume 29, Issue 1, 1990. Chemical & Physical Properties Molecular Formula C29H35NO5 Exact Mass 477.251526 PSA 92.70000 Index of Refraction 1.590 InChIKey ZMAODHOXRBLOQO-TZVKRXPSSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1544 International Maritime Transport Danger Regulations: 1544 International Air Transport Danger Regulations: 1544 14.2 United Nations shipping name European Land Transport Dangerous Regulations: ALKALOIDS, SOLID, N.O.S. (7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa- 6(12),13(?),21(?)-triene-1,20,23-trione) IMDG: ALKALOIDS, SOLID, N.O.S. (7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa- 6(12),13(?),21(?)-triene-1,20,23-trione) International Air Transport Risk Regulations: Alkaloids, solid, n.o.s. (7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa- 6(12),13(?),21(?)-triene-1,20,23-trione) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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