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curvularin structure, CAS 10140-70-2

curvularin

CAS Number10140-70-2

Synonymscurvularin

Molecular FormulaC16H20O5

Molecular Weight292.32700

Purity

Density1.2g/cm3

Boiling Point557ºC at 760mmHg

Melting Point205-207 °C

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-1177709 Purity:
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Quality Control of [ 10140-70-2 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number10140-70-2
Catalog No.2A-1177709
Chinese Name弯孢霉菌素
Synonymscurvularin
Molecular FormulaC16H20O5
Molecular Weight292.32700
Density1.2g/cm3
Boiling Point557ºC at 760mmHg
Melting Point205-207 °C
Appearancesolid
Storage Condition-20°C, sealed, dry, protected from light
ApplicationCurvularin is a fungal metabolite and potent mycotoxin extracted from Curvularia lunata. It can inhibit cytokine-induced NO synthase with an IC50 value of 9.5 µM.
SMILESCC1CCCCCC(=O)c2c(O)cc(O)cc2CC(=O)O1
InChIInChI=1S/C16H20O5/c1-10-5-3-2-4-6-13(18)16-11(8-15(20)21-10)7-12(17)9-14(16)19/h7,9-10,17,19H,2-6,8H2,1H3
InChI KeyVDUIGYAPSXCJFC-JTQLQIEISA-N
Hazard Symbolstransportation
MSDSmsds/178295_2_10140_70_2.pdf
BioactivityCurvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Immunology/Inflammation >> NO Synthase Target IC50: 9.5 µM (iNOS)[2]. References [1]. Kumar CG, et al. Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India. Springerplus. 2013 Dec;2(1):122. [2]. Yao Y, et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol Pharmacol. 2003 Feb;63(2):383-91. Chemical & Physical Properties Density 1.2g/cm3 Boiling Point 557ºC at 760mmHg Melting Point 205-207 °C Molecular Formula C16H20O5 Molecular Weight 292.32700 Flash Point 207.9ºC Exact Mass 292.13100 PSA 83.83000 LogP 2.71880 Vapour Pressure 5.18E-13mmHg at 25°C Index of Refraction 1.54 InChIKey VDUIGYAPSXCJFC-JTQLQIEISA-N SMILES CC1CCCCCC(=O)c2c(O)cc(O)cc2CC(=O)O1
Use ofCurvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM[1][2]. Properties Articles15 Name 2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-, (-) Synonym More Synonyms Curvularin Biological Activity Description Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Immunology/Inflammation >> NO Synthase IC50: 9.5 µM (iNOS)[2]. References [1]. Kumar CG, et al. Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India. Springerplus. 2013 Dec;2(1):122. [2]. Yao Y, et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol Pharmacol. 2003 Feb;63(2):383-91. Chemical & Physical Properties Molecular Formula C16H20O5 Exact Mass 292.13100 PSA 83.83000 LogP 2.71880 Index of Refraction 1.54 InChIKey VDUIGYAPSXCJFC-JTQLQIEISA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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