| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1231930-82-7 |
| Catalog No. | 2A-1170938 |
| Chinese Name | N-[5-[(4-乙基-1-哌嗪基)甲基]-2-吡啶基]-5-氟-4-[4-氟-2-甲基-1-异丙基-1H-苯并咪唑-6-基]-2-嘧啶胺甲烷磺酸盐 |
| Synonyms | CS-1229; QCR-274; UNII-KKT462Q807; LY2835219; Abemaciclib mesylate |
| Molecular Formula | C28H36F2N8O3S |
| Molecular Weight | 602.699 |
| Purity | 98% |
| Appearance | white powder |
| Storage Condition | Room temperature, dry, sealed |
| Application | Abemaciclib (LY2835219) (methanesulfonate) is a selective CDK4/6 inhibitor with IC50s of 2 nM and 10 nM for CDK4/CDK6 inhibition, respectively. |
| PubChem ID | 163621009 |
| SMILES | CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1.CS(=O)(=O)O |
| InChI | InChI=1S/C27H32F2N8.CH4O3S/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26;1-5(2,3)4/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34);1H3,(H,2,3,4) |
| InChI Key | NCJPFQPEVDHJAZ-UHFFFAOYSA-N |
| Transport Info | Product name: Abemaciclib(LY2835219) |
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