JAK INHIBITOR I

Name: JAK INHIBITOR I
Brand: 2A Biotech
SKU: 2A-1170198

CAS Number457081-03-7

SynonymsIZA; Merck-5; 9-Fluoro-2-(2-methyl-2-propanyl)-1,6-dihydro-7H-benzo[h]imidazo[4,5-f]isoquinolin-7-one

Molecular FormulaC18H16FN3O

Molecular Weight309.337

Density1.3±0.1 g/cm3

Boiling Point646.5±55.0 °C at 760 mmHg

Cat. No.: 2A-1170198 Purity:

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Quality Control of [ 457081-03-7 ] SDS Specification MoL

Chemical & Physical Properties
CAS Number	457081-03-7
Catalog No.	2A-1170198
Chinese Name	吡啶酮6
Synonyms	IZA; Merck-5; 9-Fluoro-2-(2-methyl-2-propanyl)-1,6-dihydro-7H-benzo[h]imidazo[4,5-f]isoquinolin-7-one
Molecular Formula	C18H16FN3O
Molecular Weight	309.337
Density	1.3±0.1 g/cm3
Boiling Point	646.5±55.0 °C at 760 mmHg
Storage Condition	2-8℃
Application	Pyridone 6 is a pan-JAK inhibitor that effectively inhibits the JAK kinase family, acting on JAK2, TYK2, JAK3 and JAK1, with IC50s of 1 nM, 1 nM, 5 nM and 15 nM respectively.
PubChem ID	8149086
SMILES	CC(C)(C)c1nc2c3cc[nH]c(=O)c3c3cc(F)ccc3c2[nH]1
InChI	InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
InChI Key	VNDWQCSOSCCWIP-UHFFFAOYSA-N
Transport Info	Product Name: Pyridone 6

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