CO-1686

Name: CO-1686
Brand: 2A Biotech
SKU: 2A-1170189

CAS Number1374640-70-6

SynonymsUNII: 72AH61702G; CO-1686; CO-1686(AVL-301); Rociletinib; CO 1686; S7284,CNX-419,AVL-301; Rociletinib(CO-1686)

Molecular FormulaC27H28F3N7O3

Molecular Weight555.552

Density1.4±0.1 g/cm3

Cat. No.: 2A-1170189 Purity:

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Quality Control of [ 1374640-70-6 ] SDS Specification MoL

Chemical & Physical Properties
CAS Number	1374640-70-6
Catalog No.	2A-1170189
Chinese Name	罗西替尼
Synonyms	UNII: 72AH61702G; CO-1686; CO-1686(AVL-301); Rociletinib; CO 1686; S7284,CNX-419,AVL-301; Rociletinib(CO-1686)
Molecular Formula	C27H28F3N7O3
Molecular Weight	555.552
Density	1.4±0.1 g/cm3
Storage Condition	-20°C
Application	Rociletinib (CO-1686) is an orally available EGFR inhibitor that inhibits the activity of EGFRL858R/T790M and EGFRWT with IC50 values of 21.5 nM and 303.3 nM, respectively.
HTC	29335990
PubChem ID	136337802
SMILES	C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3OC)ncc2C(F)(F)F)c1
InChI	InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
InChI Key	HUFOZJXAKZVRNJ-UHFFFAOYSA-N
Transport Info	Product name: CO-1686(AVL-301)

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