CAS Number105454-04-4
SynonymsBMS 181339-01; Plaxicel; Paxceed; Yewtaxan; Paclitaxel; TaxAlbin; Peclitaxel; Epitaxol; Taxol; Paxene; Taxol A; LipoPac; 7-Epi Paclitaxel; Ebetaxel; 7-epi-Taxol; Anzatax; UNII-P88XT4IS4D; baccatin III N-benzyl-b-phenylisoserine ester; Onxol
Molecular FormulaC47H51NO14
Molecular Weight853.906
Purity98.00%
Density1.4±0.1 g/cm3
Boiling Point957.1±65.0 °C at 760 mmHg
Melting Point168-170?C
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 105454-04-4 |
| Catalog No. | 2A-1170148 |
| Chinese Name | 7-表紫杉醇 |
| Synonyms | BMS 181339-01; Plaxicel; Paxceed; Yewtaxan; Paclitaxel; TaxAlbin; Peclitaxel; Epitaxol; Taxol; Paxene; Taxol A; LipoPac; 7-Epi Paclitaxel; Ebetaxel; 7-epi-Taxol; Anzatax; UNII-P88XT4IS4D; baccatin III N-benzyl-b-phenylisoserine ester; Onxol |
| Molecular Formula | C47H51NO14 |
| Molecular Weight | 853.906 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 957.1±65.0 °C at 760 mmHg |
| Melting Point | 168-170?C |
| Appearance | powder |
| Storage Condition | -20°C Freezer, Under Inert Atmosphere |
| Application | 7-epi-Taxol is the active metabolite of taxol, which is equivalent to taxol in inhibiting cell proliferation, microtubule dissociation, and inducing microtubule polymerization. |
| HTC | 2932999026 |
| PubChem ID | 10260125 |
| SMILES | CC(=O)OC1C(=O)C2(C)C(O)CC3OCC3(OC(C)=O)C2C(OC(=O)c2ccccc2)C2(O)CC(OC(=O)C(O)C(NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C |
| InChI | InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32+,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1 |
| InChI Key | RCINICONZNJXQF-LYTKHFMESA-N |
| Use of | 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization. Properties Name 7-Epitaxol Synonym More Synonyms 7-Epitaxol Biological Activity Description 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Cancer Natural Products >> Terpenoids and Glycosides Microtubule/Tubulin[2] In Vitro 7-epi-Taxol (7-Epitaxol) is a metabolite of taxol[1]. 7-epi-Taxol has activity comparable to that of taxol on cell replication, microtubule bundle formation and in vitro microtubule polymerization[2]. References [1]. Royer I, et al. Paclitaxel metabolites in human plasma and urine: identification of 6 alpha-hydroxytaxol, 7-epitaxol and taxol hydrolysis products using liquid chromatography/atmospheric-pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom. 1995;9(6):495-502. [2]. Ringel I, et al. Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture medium. J Pharmacol Exp Ther. 1987 Aug;242(2):692-8. Chemical & Physical Properties Molecular Formula C47H51NO14 Exact Mass 853.330933 PSA 221.29000 Index of Refraction 1.637 InChIKey RCINICONZNJXQF-LYTKHFMESA-N Safety Information HS Code 2932999026 Precursor & DownStream Precursor 0 DownStream 2 CAS#:32981-85-4 Bz-RS-iSer(3-Ph)-OMe CAS#:71629-92-0 10-Deacetyl |
| Transport Info | Product name: 7-epipaclitaxel |
| Related Products in Alkaloids | ||
|---|---|---|
| (+/-)-NICOTINE | 22083-74-5 | 2A-1166751 |
| TETRAHYDROPIPERINE | 23434-88-0 | 2A-1166760 |
| 2-Oxaindolizidine | 6833-37-0 | 2A-1167609 |
| LAPPACONITINE HYDROBROMIDE | 97792-45-5 | 2A-1168627 |
| N-DESMETHYLGALANTHAMINE | 41303-74-6 | 2A-1170025 |
| SANGUINARINE (RG) | 92545-30-7 | 2A-1170446 |
| platyphylline | 480-78-4 | 2A-1170811 |
| L-N-METHYLEPHEDRINE HYDROCHLORIDE | 38455-90-2 | 2A-1171310 |
| ACETYLTAXOL, 7-(P) | 92950-39-5 | 2A-1172526 |
| 7-EPI-10-DEACETYLTAXOL | 78454-17-8 | 2A-1172529 |
| Browse all Alkaloids products » | ||
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