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Home > Products > Natural Products & Standards > Alkaloids > LAPPACONITINE HYDROBROMIDE
LAPPACONITINE HYDROBROMIDE structure, CAS 97792-45-5

LAPPACONITINE HYDROBROMIDE

CAS Number97792-45-5

Synonymslappaconitine hydrobromide

Molecular FormulaC32H45BrN2O8

Molecular Weight665.612

Purity

Density

Boiling Point740.8ºC at 760 mmHg

Melting Point223-226ºC

Flash Point

Appearancewhite powder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-1168627 Purity:
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Quality Control of [ 97792-45-5 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number97792-45-5
Catalog No.2A-1168627
Chinese Name高乌甲素氢溴酸盐
Synonymslappaconitine hydrobromide
Molecular FormulaC32H45BrN2O8
Molecular Weight665.612
Boiling Point740.8ºC at 760 mmHg
Melting Point223-226ºC
Appearancewhite powder
Storage Condition2-8°C
PackagingII
ApplicationLappaconitine hydrobromide is a natural alkaloid compound with anti-arrhythmic effects.
HTC29399990
PubChem ID135015582
SMILESBr.CCN1CC2(OC(=O)c3ccccc3NC(C)=O)CCC(OC)C34C1C(CC23)C1(O)CC(OC)C2CC4C1(O)C2OC
InChIInChI=1S/C32H44N2O8.BrH/c1-17(35)33-20-9-7-6-8-18(20)21(36)13-28-11-10-24(40-3)31-22(28)12-19(26(31)34(2)16-28)30(38)15-25(41-4)29(37)14-23(31)32(30,39)27(29)42-5;/h6-9,19,22-27,37-39H,10-16H2,1-5H3,(H,33,35);1H/t19?,22-,23+,24?,25?,26-,27?,28?,29+,30+,31?,32+;/m1./s1
InChI KeyCFFYROOPXPKMEQ-OPLXFBIMSA-N
MSDSmsds/168687_2_97792_45_5.pdf
BioactivityLappaconitine hydrobromide, a diterpene alkaloid, is a drug for the treatment of cardiac arrhythmias.IC50 value:Target: A natural product for anti-cardiac arrhythmiasIn vitro: Lappaconitine hydrobromide was found to exert an inhibitory effect on inward tetrodotoxin-sensitive sodium currents without changing their voltage dependence [1]. In vivo: The effect of Lappaconitine hydrobromide on aconitine--induced arrhythmias is due to modulation of genes encoding Na(+)-, K(+)-, Ca(2+)-channels, conducting ionic currents (I(Na), I(to), I(Ks), I(K1), I(CaT)), which are involved in the formation of different phases of the action potential [2]. Lappaconitine hydrobromide was found to be beneficial both in ventricular and supraventricular premature beats. Oral allapinine usually showed its effect 40-60 minutes following its administration, its maximum action being 4-5 hours later, its duration was some 8 hours. The optimal dose of the drug amounted to 75 mg/day [3]. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Cardiovascular Disease References [1]. A. E. Valeev, et al. Effects of allapinine on sodium currents in neurons isolated from the rat trigeminal ganglion and cardiomyocytes. Neurophysiology, 1990, 22 (2): 157-162. [2]. Vakhitova IuV, et al. To the mechanisms of antiarrhythmic action of Allapinine. Bioorg Khim, 2013, 39 (1):105-16 [3]. Abdalla A., et al. Allapinine pharmacodynamics and potential adverse effects. Kardiologiya. 29(7): 29-32 Chemical & Physical Properties Boiling Point 740.8ºC at 760 mmHg Melting Point 223-226ºC Molecular Formula C32H45BrN2O8 Molecular Weight 665.612 Flash Point 401.8ºC Exact Mass 664.235901 PSA 126.79000 LogP 3.19060 InChIKey CFFYROOPXPKMEQ-OPLXFBIMSA-N SMILES Br.CCN1CC2(OC(=O)c3ccccc3NC(C)=O)CCC(OC)C34C1C(CC23)C1(O)CC(OC)C2CC4C1(O)C2OC Storage condition 2-8°C
Use ofProperties Name Lappaconitine Hydrobromide Synonym More Synonyms Lappaconitine Hydrobromide Biological Activity Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Cardiovascular Disease References [1]. A. E. Valeev, et al. Effects of allapinine on sodium currents in neurons isolated from the rat trigeminal ganglion and cardiomyocytes. Neurophysiology, 1990, 22 (2): 157-162. [2]. Vakhitova IuV, et al. To the mechanisms of antiarrhythmic action of Allapinine. Bioorg Khim, 2013, 39 (1):105-16 [3]. Abdalla A., et al. Allapinine pharmacodynamics and potential adverse effects. Kardiologiya. 29(7): 29-32 Chemical & Physical Properties Molecular Formula C32H45BrN2O8 Exact Mass 664.235901 PSA 126.79000 LogP 3.19060 InChIKey CFFYROOPXPKMEQ-OPLXFBIMSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 1544 Formal shipping name: Alkaloid salt, solid, not otherwise specified Packing grade: II
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