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Home > Products > Natural Products & Standards > Alkaloids > PHYSOSTIGMINE SALICYLATE
PHYSOSTIGMINE SALICYLATE structure, CAS 57-64-7

PHYSOSTIGMINE SALICYLATE

CAS Number57-64-7

SynonymsEINECS 200-343-8; MFCD00135659; Physostigmine Salicylate

Molecular FormulaC22H27N3O5

Molecular Weight413.46700

Purity96%

Density

Boiling Point393.5ºC at 760 mmHg

Melting Point181-183 °C

Flash Point

AppearanceColorless crystal, odorless

EINECS

MSDSChineseEnglish

Symbol6.1(a)

Signal WordWarning

Cat. No.: 2A-1166692 Purity: 96%
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Quality Control of [ 57-64-7 ] Purity: 96% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number57-64-7
Catalog No.2A-1166692
Chinese Name水杨酸毒扁豆碱
SynonymsEINECS 200-343-8; MFCD00135659; Physostigmine Salicylate
Molecular FormulaC22H27N3O5
Molecular Weight413.46700
Purity96
Boiling Point393.5ºC at 760 mmHg
Melting Point181-183 °C
AppearanceColorless crystal, odorless
Storage Condition2-8°C
PackagingII
ApplicationPhysostigmine salicylate (Eserine salicylate) is a reversible inhibitor of acetylcholinesterase (AChE). Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neur
HTC2933990090
PubChem ID855875
SMILESCNC(=O)Oc1ccc2c(c1)C1(C)CCN(C)C1N2C.O=C(O)c1ccccc1O
InChIInChI=1S/C15H21N3O2.C7H6O3/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2;8-6-4-2-1-3-5(6)7(9)10/h5-6,9,13H,7-8H2,1-4H3,(H,16,19);1-4,8H,(H,9,10)/t13-,15+;/m1./s1
InChI KeyHZOTZTANVBDFOF-PBCQUBLHSA-N
Hazard Symbols6.1(a)
BioactivityPhysostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning[1][2][3][4]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE In Vivo Physostigmine salicylate (Eserine salicylate; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice[2]. Physostigmine salicylate (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats[4]. Animal Model: Heterozygous transgenic mice (Tg(+) mice)[2] Dosage: 0.03, 0.1, and 0.3 mg/kg Administration: SC; daily for 6 weeks Result: Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals. References [1]. Haase U, et al. Pharmakotherapie--physostigmin post OP [Pharmacotherapy--physostigmine administered post-operatively]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2007;42(3):188‐189. [2]. Dong H, et al, Bertchume A, Vallera D, Csernansky JG. Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease. Psychopharmacology (Berl). 2005;181(1):145‐152. [3]. Frascogna N. Physostigmine: is there a role for this antidote in pediatric poisonings?. Curr Opin Pediatr. 2007;19(2):201‐205. [4]. Jonathan D Kenny, et al. Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats. Anesth Analg. 2016 Nov;123(5):1210-1219. Chemical & Physical Properties Boiling Point 393.5ºC at 760 mmHg Melting Point 181-183 °C Molecular Formula C22H27N3O5 Molecular Weight 413.46700 Flash Point 191.8ºC Exact Mass 413.19500 PSA 102.34000 LogP 3.25810 InChIKey HZOTZTANVBDFOF-PBCQUBLHSA-N SMILES CNC(=O)Oc1ccc2c(c1)C1(C)CCN(C)C1N2C.O=C(O)c1ccccc1O Storage condition 2-8°C
Use ofPhysostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning[1][2][3][4]. Properties Articles25 Name Eserine Salicylate Synonym More Synonyms Physostigmine salicylate Biological Activity Description Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning[1][2][3][4]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE References [1]. Haase U, et al. Pharmakotherapie--physostigmin post OP [Pharmacotherapy--physostigmine administered post-operatively]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2007;42(3):188‐189. [3]. Frascogna N. Physostigmine: is there a role for this antidote in pediatric poisonings?. Curr Opin Pediatr. 2007;19(2):201‐205. [4]. Jonathan D Kenny, et al. Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats. Anesth Analg. 2016 Nov;123(5):1210-1219. Chemical & Physical Properties Molecular Formula C22H27N3O5 Exact Mass 413.19500 PSA 102.34000 LogP 3.25810 InChIKey HZOTZTANVBDFOF-PBCQUBLHSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 1544 Formal shipping name: Alkaloid salt, solid, not otherwise specified Packing grade: I
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