CAS Number70-30-4
Synonyms2,2'-méthanediylbis(3,4,6-trichlorophénol); Germa-Medica; 2,2'-Methandiylbis(3,4,6-trichlorbenzolol); Nabac; 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol; hexachlorophene; EINECS 200-733-8; HCP; MFCD00002171; 2,2-Methylenebis(3,4,6-Trichlorophenol); 2,2'-Methylenebis(3,4,6-trichlorophenol); Trichlorophene
Molecular FormulaCH2[C6H(Cl)3OH]2
Molecular Weight406.90
Purity98.00%
Density1.7±0.1 g/cm3
Boiling Point470.9±40.0 °C at 760 mmHg
Melting Point163-165 °C (lit.)
AppearanceOff-white to purple powder
EINECS200-733-8
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 70-30-4 |
| Catalog No. | 2A-9017001 |
| Chinese Name | 六氯酚 |
| Synonyms | 2,2'-méthanediylbis(3,4,6-trichlorophénol); Germa-Medica; 2,2'-Methandiylbis(3,4,6-trichlorbenzolol); Nabac; 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol; hexachlorophene; EINECS 200-733-8; HCP; MFCD00002171; 2,2-Methylenebis(3,4,6-Trichlorophenol); 2,2'-Methylenebis(3,4,6-trichlorophenol); Trichlorophene |
| Molecular Formula | CH2[C6H(Cl)3OH]2 |
| Molecular Weight | 406.90 |
| Purity | 98.00 |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 470.9±40.0 °C at 760 mmHg |
| Melting Point | 163-165 °C (lit.) |
| Appearance | Off-white to purple powder |
| Storage Condition | The warehouse is ventilated and dried at low tempe |
| Packaging | III |
| Application | Hexachlorophene (Hexachlorofen) has been shown to be a KCNQ1/KCNE1 potassium channel agonist with an EC50 value of 4.61uM. It is also an inhibitor of the Wnt/beta-catenin signaling pathway. |
| EINECS | 200-733-8 |
| HTC | 2907299010 |
| PubChem ID | 329756812 |
| MDL Number | MFCD00002171 |
| SMILES | Oc1c(Cl)cc(Cl)c(Cl)c1Cc2c(O)c(Cl)cc(Cl)c2Cl |
| InChI | 1S/C13H6Cl6O2/c14-6-2-8(16)12(20)4(10(6)18)1-5-11(19)7(15)3-9(17)13(5)21/h2-3,20-21H,1H2 |
| InChI Key | ACGUYXCXAPNIKK-UHFFFAOYSA-N |
| Beilstein/REAXYS | 2064407 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/17001_1_70_30_4.pdf |
| Bioactivity | Hexachlorophene(Hexachlorofen) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; also is an inhibitor of Wnt/beta-catenin signaling.IC50 value: 4.61 ± 1.29 μM(EC50) [1]Target: KCNQ1 activatorin vitro: HCP potently increases the current amplitude of KCNQ1/KCNE1 expressed by stabilizing the channel in an open state with an EC(50) of 4.61 ± 1.29 μM. Further studies in cardiomyocytes showed that HCP significantly shortens the action potential duration at 1 μM. In addition, HCP is capable of rescuing the loss of function of the LQTs mutants caused by either impaired activation gating or phosphatidylinositol-4,5-bisphosphate (PIP2) binding affinity [1]. Hexachlorophene antagonized CRT that was stimulated by Wnt3a-conditioned medium by promoting the degradation of beta-catenin. hexachlorophene represses the expression of cyclin D1 [2]. Triclosan and hexachlorophene inhibited both ecFabI and saFabI. hexachlorophene prevented the formation of a stable FabI-NAD(P)(+)-drug ternary complex [3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Signaling Pathways >> Stem Cell/Wnt >> Wnt Research Areas >> Others References [1]. Zheng Y, et al. Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants. PLoS One. 2012;7(12):e51820. [2]. Park S, et al. Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation. Mol Pharmacol. 2006 Sep;70(3):960-6. [3]. Heath RJ, et al. Inhibition of the Staphylococcus aureus NADPH-dependent enoyl-acyl carrier protein reductase by triclosan and hexachlorophene. J Biol Chem. 2000 Feb 18;275(7):4654-9. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 470.9±40.0 °C at 760 mmHg Melting Point 163-165 °C(lit.) Molecular Formula C13H6Cl6O2 Molecular Weight 406.904 Flash Point 238.6±27.3 °C Exact Mass 403.849884 PSA 40.46000 LogP 7.20 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.670 InChIKey ACGUYXCXAPNIKK-UHFFFAOYSA-N SMILES Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl Stability Stable. Incompatible with alkalies, akaline earths, tweens, strong oxidizers. |
| Use of | Properties Articles47 Name hexachlorophene Synonym More Synonyms Hexachlorophene Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Signaling Pathways >> Stem Cell/Wnt >> Wnt Research Areas >> Others References [2]. Park S, et al. Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation. Mol Pharmacol. 2006 Sep;70(3):960-6. [3]. Heath RJ, et al. Inhibition of the Staphylococcus aureus NADPH-dependent enoyl-acyl carrier protein reductase by triclosan and hexachlorophene. J Biol Chem. 2000 Feb 18;275(7):4654-9. Chemical & Physical Properties Exact Mass 403.849884 PSA 40.46000 Index of Refraction 1.670 InChIKey ACGUYXCXAPNIKK-UHFFFAOYSA-N Stability Stable. Incompatible with alkalies, akaline earths, tweens, strong oxidizers. |
| Tax Rebate | 0.0% |
| Supervision | S. Import and export pesticide registration certificate |
| Transport Info | Product name: Chemical name |
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