CAS Number71-00-1
Synonyms(S)-a-Amino-1H-imidazole-4-propanoic Acid; (S)-1H-Imidazole-4-alanine; a-Amino-4(or 5)-Imidazolepropionic Acid; d,l-histidine; FEMA 3694; (S)-histidine; EINECS 200-745-3; His; Histidine; H-L-HIS-OH; 3-(1H-imidazol-4-yl)-L-Alanine; hydrogen L-histidinate; L-His; Histidin; L-Histdine; L-Hisidine; MFCD00064315; L-Histidine; H-His-OH
Molecular FormulaC6H9N3O2
Molecular Weight155.15
Purity98.5-101.0%
Density1.4±0.1 g/cm3
Boiling Point458.9±35.0 °C at 760 mmHg
Melting Point282 °C (dec.) (lit.)
Appearancepowder
EINECS200-745-3
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 71-00-1 |
| Catalog No. | 2A-9017011 |
| Chinese Name | L-组氨酸 |
| Synonyms | (S)-a-Amino-1H-imidazole-4-propanoic Acid; (S)-1H-Imidazole-4-alanine; a-Amino-4(or 5)-Imidazolepropionic Acid; d,l-histidine; FEMA 3694; (S)-histidine; EINECS 200-745-3; His; Histidine; H-L-HIS-OH; 3-(1H-imidazol-4-yl)-L-Alanine; hydrogen L-histidinate; L-His; Histidin; L-Histdine; L-Hisidine; MFCD00064315; L-Histidine; H-His-OH |
| Molecular Formula | C6H9N3O2 |
| Molecular Weight | 155.15 |
| Purity | 98.5-101.0 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 458.9±35.0 °C at 760 mmHg |
| Melting Point | 282 °C (dec.) (lit.) |
| Appearance | powder |
| Water Solubility | 41.6 g/L (25 ºC) |
| Storage Condition | ①The basic amino acid part of protein hydrolyzate |
| Application | L-Hisidine is an essential amino acid for babies. L-Hisidine is an inhibitor of mitochondrial glutamine transport. |
| EINECS | 200-745-3 |
| HTC | 2933290090 |
| PubChem ID | 24895728 |
| MDL Number | MFCD00064315 |
| SMILES | N[C@@H](Cc1c[nH]cn1)C(O)=O |
| InChI | 1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 |
| InChI Key | HNDVDQJCIGZPNO-YFKPBYRVSA-N |
| Beilstein/REAXYS | 84088 |
| NACRES Code | NA.26 |
| eCl@ss | 32160406 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| MSDS | msds/17011_1_71_00_1.pdf |
| Bioactivity | L-Hisidine is an essential amino acid for infants. L-Hisidine is an inhibitor of mitochondrial glutamine transport. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Mitochondrial Metabolism Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Natural Products >> Others In Vitro L-histidine completely inhibits growth and its effect on viability is inversely related to FLO11 expression. L-histidine does not affect the viability of the Δflo11 and S288c strains. L-histidine dramatically decreases air-liquid biofilm formation and adhesion to polystyrene of the flor yeasts with no effect on the transcription level of the FLO11 gene. Moreover, L-histidine modifies the chitin and glycans content on the cell-wall of flor yeasts[1]. In Vivo L-histidine (100 mg/kg) completely inhibits the brain edema in thioacetamide-treated rats[2]. Histamine release stimulated by high K+ from the hypothalamus in the L-histidine diet group is 60% of that in the control group. However, the concentrations of other monoamines and their metabolites are not changed by the L-histidine diet. The open-field tests show that the L-histidine diet group spends a shorter amount of time in the central zone, and the light/dark box tests demonstrate that the L-histidine diet group spends a shorter amount of time in the light box, suggesting that the L-histidine diet induced anxiety-like behaviors[3]. Animal Admin Rats: TAA (300 mg/kg i.p) is given to animals daily for 3 days. L-histidine (100 mg/kg) is dissolved in saline and injected (i.p.) daily 2 hours before each TAA injection. To prevent hypoglycemia and dehydration, rats are given 12.5 ml/kg of fluid therapy (5% dextrose and 0.45% saline with 20 mEq/L of potassium chloride) every 12 hours, s.c. Normal controls receive saline (vehicle used for TAA), whereas another group of rats are given L-histidine alone (100 mg/kg) daily for 3 days. TAA-treated rats are clinically monitored, and stages of encephalopathy are graded[2]. Mice: The control group is fed with the AIN-93G purified diet that contains 5.08 g L-histidine/kg, whereas the L-histidine diet group is fed with AIN-93G that contains 1.28 g L-histidine/kg (25% of the histidine content in AIN-93G). To equalize the total amount of amino acids, glutamine is added to the L-histidine diet to counterbalance the changes in the histidine content (18.32 g L-glutamine/kg AIN-93G vs. 23.72 g L-glutamine/kg L-histidine diet). Both diets are isonitrogenous. At 8 wk of age, the mice are weighed and assigned to 2 different diets. The mice are allowed ad libitum access to water and their respective diets, and they are housed for at least 2 wk in the laboratory before starting the experiments[3]. References [1]. Bou Zeidan M, et al. L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts. PLoS One. 2014 Nov 4;9(11):e112141. [2]. Rama Rao KV, et al. Brain edema in acute liver failure: inhibition by L-histidine. Am J Pathol. 2010 Mar;176(3):1400-8. [3]. Yoshikawa T, et al. Insufficient intake of L-histidine reduces brain histamine and causes anxiety-like behaviors in male mice. J Nutr. 2014 Oct;144(10):1637-41. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 458.9±35.0 °C at 760 mmHg Melting Point 282 °C (dec.)(lit.) Molecular Formula C6H9N3O2 Molecular Weight 155.155 Flash Point 231.3±25.9 °C Exact Mass 155.069473 PSA 92.00000 LogP -1.26 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.615 InChIKey HNDVDQJCIGZPNO-YFKPBYRVSA-N SMILES NC(Cc1cnc[nH]1)C(=O)O Water Solubility 41.6 g/L (25 ºC) |
| Use of | L-Hisidine is an essential amino acid for infants. L-Hisidine is an inhibitor of mitochondrial glutamine transport. Properties Articles304 Name L-histidine Synonym More Synonyms L-Histidine Biological Activity Description L-Hisidine is an essential amino acid for infants. L-Hisidine is an inhibitor of mitochondrial glutamine transport. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Mitochondrial Metabolism Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Natural Products >> Others References [1]. Bou Zeidan M, et al. L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts. PLoS One. 2014 Nov 4;9(11):e112141. [2]. Rama Rao KV, et al. Brain edema in acute liver failure: inhibition by L-histidine. Am J Pathol. 2010 Mar;176(3):1400-8. [3]. Yoshikawa T, et al. Insufficient intake of L-histidine reduces brain histamine and causes anxiety-like behaviors in male mice. J Nutr. 2014 Oct;144(10):1637-41. Chemical & Physical Properties Molecular Formula C6H9N3O2 Exact Mass 155.069473 PSA 92.00000 LogP -1.26 Index of Refraction 1.615 InChIKey HNDVDQJCIGZPNO-YFKPBYRVSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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