CAS Number7481-89-2
SynonymsddCyd; [3H]-Zalcitabine; 2',3'-DIDEOXYCYTIDINE; 4-Amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one; DDC; DDC (VAN); Zalcitabine; 1-[(2R,5S)-5-(Hydroxymethyl)tetrahydro-2-furanyl]-4-imino-1,4-dihydro-2-pyrimidinol; 4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one; HIVID; MFCD00012188; 4-Amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydro-2-furanyl]-2(1H)-pyrimidinone; Cytidine,2',3'-dideoxy; Dideoxycytidine; 3'-Azido-3'-deoxythymidine; 4-Amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-on; Zalcitibine; 2',3'-Dideoxycytidinene; ddC (Antiviral); 4-amino-1-[(2R,5S)-5-(hydroxyméthyl)tétrahydrofuran-2-yl]pyrimidin-2(1H)-one
Molecular FormulaC9H13N3O3
Molecular Weight211.22
Purity≥98 (HPLC)%
Density1.6±0.1 g/cm3
Boiling Point415.0±55.0 °C at 760 mmHg
Melting Point217-218 °C (lit.)
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 7481-89-2 |
| Catalog No. | 2A-9001680 |
| Chinese Name | 2',3'-二脱氧胞苷 |
| Synonyms | ddCyd; [3H]-Zalcitabine; 2',3'-DIDEOXYCYTIDINE; 4-Amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one; DDC; DDC (VAN); Zalcitabine; 1-[(2R,5S)-5-(Hydroxymethyl)tetrahydro-2-furanyl]-4-imino-1,4-dihydro-2-pyrimidinol; 4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one; HIVID; MFCD00012188; 4-Amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydro-2-furanyl]-2(1H)-pyrimidinone; Cytidine,2',3'-dideoxy; Dideoxycytidine; 3'-Azido-3'-deoxythymidine; 4-Amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-on; Zalcitibine; 2',3'-Dideoxycytidinene; ddC (Antiviral); 4-amino-1-[(2R,5S)-5-(hydroxyméthyl)tétrahydrofuran-2-yl]pyrimidin-2(1H)-one |
| Molecular Formula | C9H13N3O3 |
| Molecular Weight | 211.22 |
| Purity | ≥98 (HPLC) |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 415.0±55.0 °C at 760 mmHg |
| Melting Point | 217-218 °C (lit.) |
| Appearance | powder |
| Water Solubility | 5-10 g/100 mL at 19 ºC |
| Storage Condition | Sealed in a cool, dry environment |
| Application | Zalcitabine is a potent nucleoside analog reverse transcriptase inhibitor used to treat HIV infection. |
| HTC | 2934999090 |
| PubChem ID | 24278377 |
| MDL Number | MFCD00012188 |
| SMILES | NC1=NC(=O)N(C=C1)[C@H]2CC[C@@H](CO)O2 |
| InChI | 1S/C9H13N3O3/c10-7-3-4-12(9(14)11-7)8-2-1-6(5-13)15-8/h3-4,6,8,13H,1-2,5H2,(H2,10,11,14)/t6-,8+/m0/s1 |
| InChI Key | WREGKURFCTUGRC-POYBYMJQSA-N |
| Beilstein/REAXYS | 654956 |
| NACRES Code | NA.52 |
| UNSPSC | 41106305 |
| Hazard Symbols | Transport |
| Risk Codes | R40 |
| Safety Description | S22;S36 |
| MSDS | msds/1680_1_7481_89_2.pdf |
| Bioactivity | Zalcitabine is a potent nucleoside analogue reverse transcriptase inhibitor used in the treatment of HIV infection. Related Catalog Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection Target Target: HIV In Vitro Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain[1]. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells[2]. References [1]. Adkins JC, et al. Zalcitabine. An update of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of HIV infection.Drugs. 1997 Jun;53(6):1054-80 [2]. Jin MJ, et al. Interaction of zalcitabine with human organic anion transporter 1. Pharmazie. 2006 May;61(5):491-2. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 415.0±55.0 °C at 760 mmHg Melting Point 217-218 °C(lit.) Molecular Formula C9H13N3O3 Molecular Weight 211.218 Flash Point 204.8±31.5 °C Exact Mass 211.095688 PSA 90.37000 LogP -1.30 Vapour Pressure 0.0±2.2 mmHg at 25°C Index of Refraction 1.686 InChIKey WREGKURFCTUGRC-POYBYMJQSA-N SMILES Nc1ccn(C2CCC(CO)O2)c(=O)n1 Storage condition 2-8°C Stability Stable. Combustible. Incompatible with strong oxidizing agents. Water Solubility 5-10 g/100 mL at 19 ºC |
| Use of | Zalcitabine is a potent nucleoside analogue reverse transcriptase inhibitor used in the treatment of HIV infection. Properties Articles62 Name zalcitabine Synonym More Synonyms Zalcitabine Biological Activity Description Zalcitabine is a potent nucleoside analogue reverse transcriptase inhibitor used in the treatment of HIV infection. Related Catalog Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection Target: HIV References [1]. Adkins JC, et al. Zalcitabine. An update of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of HIV infection.Drugs. 1997 Jun;53(6):1054-80 [2]. Jin MJ, et al. Interaction of zalcitabine with human organic anion transporter 1. Pharmazie. 2006 May;61(5):491-2. Chemical & Physical Properties Molecular Formula C9H13N3O3 Exact Mass 211.095688 PSA 90.37000 LogP -1.30 Index of Refraction 1.686 InChIKey WREGKURFCTUGRC-POYBYMJQSA-N Stability Stable. Combustible. Incompatible with strong oxidizing agents. |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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