CAS Number4097-22-7
SynonymsDDA; ((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol; [(2S,5R)-5-(6-aminopurin-9-yl)oxolan-2-yl]methanol; Dideoxyadenosine; 6-Amino-9-(2',3'-dideoxy-b-D-glycero-pentofuranosyl)purine; EINECS 223-853-2; [(2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl]methanol; 2',3'-Dideoxyadenosine; 9-(2,3-Dideoxy-β-D-ribofuranosyl)adenine; MFCD00010534; 9-(2,3-Dideoxy-beta-D-ribofuranosyl)adenine; [(2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydro-2-furanyl]methanol
Molecular FormulaC10H13N5O2
Molecular Weight235.24
Purity≥97 (HPLC)%
Density1.8±0.1 g/cm3
Boiling Point539.1±60.0 °C at 760 mmHg
Melting Point181-184 °C (lit.)
Appearancepowder
EINECS223-853-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4097-22-7 |
| Catalog No. | 2A-9001679 |
| Chinese Name | 2',3'-二脱氧腺苷 |
| Synonyms | DDA; ((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol; [(2S,5R)-5-(6-aminopurin-9-yl)oxolan-2-yl]methanol; Dideoxyadenosine; 6-Amino-9-(2',3'-dideoxy-b-D-glycero-pentofuranosyl)purine; EINECS 223-853-2; [(2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl]methanol; 2',3'-Dideoxyadenosine; 9-(2,3-Dideoxy-β-D-ribofuranosyl)adenine; MFCD00010534; 9-(2,3-Dideoxy-beta-D-ribofuranosyl)adenine; [(2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydro-2-furanyl]methanol |
| Molecular Formula | C10H13N5O2 |
| Molecular Weight | 235.24 |
| Purity | ≥97 (HPLC) |
| Density | 1.8±0.1 g/cm3 |
| Boiling Point | 539.1±60.0 °C at 760 mmHg |
| Melting Point | 181-184 °C (lit.) |
| Appearance | powder |
| Storage Condition | This product should be sealed and stored at 0~4℃. |
| Application | 2',3'-Dideoxyadenosine is an inhibitor of HIV replication. Antiretroviral activity. Antiviral activity [1]. |
| EINECS | 223-853-2 |
| HTC | 2934999090 |
| PubChem ID | 24893397 |
| MDL Number | MFCD00010534 |
| SMILES | Nc1ncnc2n(cnc12)[C@H]3CC[C@@H](CO)O3 |
| InChI | 1S/C10H13N5O2/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(3-16)17-7/h4-7,16H,1-3H2,(H2,11,12,13)/t6-,7+/m0/s1 |
| InChI Key | WVXRAFOPTSTNLL-NKWVEPMBSA-N |
| Beilstein/REAXYS | 619924 |
| NACRES Code | NA.51 |
| UNSPSC | 41106305 |
| Hazard Symbols | Transport |
| MSDS | msds/1679_1_4097_22_7.pdf |
| Bioactivity | 2',3'-Dideoxyadenosine is an inhibitor of HIV replication[1]. Antiretroviral activity[1]. Antiviral efficacy[1]. Related Catalog Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Target HIV[1] In Vitro 2',3'-Dideoxyadenosine inhibits HIV-1 and simian immunodeficiency virus (SIV) in MT-4 cells with EC50s of 5.27 and 5.3 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in human T-lymphocyte CEM cells with EC50s of 4 μM and 8 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in Molt 4/C8 cells with EC50s of 4 μM and 5.5 μM, respectively. 2',3'-Dideoxyadenosine inhibits HIV-1 and HIV-2 in C8166 cells with EC50s of 17 μM and 22 μM, respectively. 2',3'-Dideoxyadenosine inhibits murine sarcoma virus (MSV) in C3H/3T3 cells with an EC50 of 24 μM[1]. References [1]. Balzarini J, et al. Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus. FEBS Lett. 1997 Jun 30;410(2-3):324-8. Chemical & Physical Properties Density 1.8±0.1 g/cm3 Boiling Point 539.1±60.0 °C at 760 mmHg Melting Point 181-184 °C(lit.) Molecular Formula C10H13N5O2 Molecular Weight 235.242 Flash Point 279.9±32.9 °C Exact Mass 235.106918 PSA 99.08000 LogP -0.43 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.822 InChIKey WVXRAFOPTSTNLL-NKWVEPMBSA-N SMILES Nc1ncnc2c1ncn2C1CCC(CO)O1 Storage condition 2-8°C |
| Use of | 2',3'-Dideoxyadenosine is an inhibitor of HIV replication[1]. Antiretroviral activity[1]. Antiviral efficacy[1]. Properties Articles35 Name 2',3'-Dideoxyadenosine Synonym More Synonyms 2',3'-Dideoxyadenosine Biological Activity Description 2',3'-Dideoxyadenosine is an inhibitor of HIV replication[1]. Antiretroviral activity[1]. Antiviral efficacy[1]. Related Catalog Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection References [1]. Balzarini J, et al. Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus. FEBS Lett. 1997 Jun 30;410(2-3):324-8. Chemical & Physical Properties Molecular Formula C10H13N5O2 Exact Mass 235.106918 PSA 99.08000 LogP -0.43 Index of Refraction 1.822 InChIKey WVXRAFOPTSTNLL-NKWVEPMBSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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