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2-Chloroadenosine structure, CAS 146-77-0

2-Chloroadenosine

CAS Number146-77-0

Synonyms6-Amino-2-chloro-9-(β-D-ribofuranosyl)purine Hydrate; 2-CADO,6-Amino-2-chloropurine riboside; 2-Chloroadenosine; 6-Amino-2-chloropurine Riboside Hydrate; 2-CADO Hydrate; EINECS 205-678-3; (2R,3R,4S,5R)-2-(6-Amino-2-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol; MFCD00005734; 2-Chlor-9-(β-D-ribofuranosyl)-9H-purin-6-amin; 6-Amino-2-Chloropurine Riboside; 2-chloro adenosine

Molecular FormulaC10H12ClN5O4

Molecular Weight301.69

Purity98%

Density2.2±0.1 g/cm3

Boiling Point643.3±65.0 °C at 760 mmHg

Melting Point162 °C

Flash Point

Appearancepowder

EINECS205-678-3

MSDSChineseEnglish

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Cat. No.: 2A-9002972 Purity: 98%
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Quality Control of [ 146-77-0 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number146-77-0
Catalog No.2A-9002972
Chinese Name2-氯腺苷
Synonyms6-Amino-2-chloro-9-(β-D-ribofuranosyl)purine Hydrate; 2-CADO,6-Amino-2-chloropurine riboside; 2-Chloroadenosine; 6-Amino-2-chloropurine Riboside Hydrate; 2-CADO Hydrate; EINECS 205-678-3; (2R,3R,4S,5R)-2-(6-Amino-2-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol; MFCD00005734; 2-Chlor-9-(β-D-ribofuranosyl)-9H-purin-6-amin; 6-Amino-2-Chloropurine Riboside; 2-chloro adenosine
Molecular FormulaC10H12ClN5O4
Molecular Weight301.69
Purity98
Density2.2±0.1 g/cm3
Boiling Point643.3±65.0 °C at 760 mmHg
Melting Point162 °C
Appearancepowder
Water SolubilityH2O: 10 mg/mL, clear, colorless
Storage ConditionStore in a dry and cool place.
Application2-Chloroadenosine, an adenosine analog, prevents long-term ischemic cell loss in the rat hippocampus. 2-Chloroadenosine is a competitive inhibitor of uridine influx (apparent Ki=33 μM) and binds to ni
EINECS205-678-3
PubChem ID24277688
MDL NumberMFCD00005734
SMILESNc1nc(Cl)nc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
InChI1S/C10H12ClN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1
InChI KeyBIXYYZIIJIXVFW-UUOKFMHZSA-N
Beilstein/REAXYS43957
NACRES CodeNA.77
UNSPSC12352200
Hazard SymbolsTransport
MSDSmsds/2972_1_146_77_0.pdf
Bioactivity2-Chloroadenosine, a stable adenosine analogue, protects against long term development of ischaemic cell loss in the rat hippocampus. 2-Chloroadenosine is an apparent competitive inhibitor of uridine influx (apparent Ki=33 μM) and high-affinity nitrobenzylthioinosine binding (apparent Ki=0.18 mM). 2-Chloroadenosine is a transported permeant for the nucleoside transporter in human erythrocytes[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Jarvis SM,2-Chloroadenosine, a permeant for the nucleoside transporter.Biochem Pharmacol. 1985 Sep 15;34(18):3237-41. [2]. Evans MC, et al. An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus.Neurosci Lett. 1987 Dec 29;83(3):287-92. Chemical & Physical Properties Density 2.2±0.1 g/cm3 Boiling Point 643.3±65.0 °C at 760 mmHg Melting Point 162 °C Molecular Formula C10H12ClN5O4 Molecular Weight 301.686 Flash Point 342.8±34.3 °C Exact Mass 301.057770 PSA 139.54000 LogP -0.46 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.912 InChIKey BIXYYZIIJIXVFW-UUOKFMHZSA-N SMILES Nc1nc(Cl)nc2c1ncn2C1OC(CO)C(O)C1O Water Solubility H2O: 10 mg/mL, clear, colorless
Use ofProperties Articles45 Name 2-Chloroadenosine Synonym More Synonyms 2-Chloroadenosine Biological Activity Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Jarvis SM,2-Chloroadenosine, a permeant for the nucleoside transporter.Biochem Pharmacol. 1985 Sep 15;34(18):3237-41. [2]. Evans MC, et al. An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus.Neurosci Lett. 1987 Dec 29;83(3):287-92. Chemical & Physical Properties Exact Mass 301.057770 PSA 139.54000 LogP -0.46 Index of Refraction 1.912 InChIKey BIXYYZIIJIXVFW-UUOKFMHZSA-N
Transport InfoProduct name: Purity: 99.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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