CAS Number58-63-9
Synonyms6-Oxopurine riboside; HXR; RIBOXINE; nosine; Ino; EINECS 200-390-4; 9-β-δ-Ribofuranosylhypoxanthine; 1,9-dihydro-9-b-D-ribofuranosyl-6H-Purin-6-one; 9-β-D-ribofuranosyl-Hypoxanthine; 9-β-D-Ribofuranosylhypoxanthine; Inosie; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxyméthyl)tétrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one; INO 495; hypoxanthine; Oxiamin; 9-b-D-Ribofuranosylhypoxanthine; Atorel; MFCD00066770; 9β-D-Ribofuranosylhypoxanthine; 6-oxy-purine riboside; 9-β-D-ribofuranosyl-1,9-dihydro-6H-purin-6-one; 9-b-D-ribofuranosyl-Hypoxanthine; Inosine; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one; T56 BN DN FN HNJ IQ D- BT5OTJ CQ DQ E1Q &&β-D-Ribo Form; Selfer
Molecular FormulaC10H12N4O5
Molecular Weight268.226
Purity99.00%
Density2.1±0.1 g/cm3
Boiling Point670.5±65.0 °C at 760 mmHg
Melting Point222-226 °C (dec.)(lit.)
Appearancewhite powder
EINECS200-390-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 58-63-9 |
| Catalog No. | 2A-9016786 |
| Chinese Name | 肌苷 |
| Synonyms | 6-Oxopurine riboside; HXR; RIBOXINE; nosine; Ino; EINECS 200-390-4; 9-β-δ-Ribofuranosylhypoxanthine; 1,9-dihydro-9-b-D-ribofuranosyl-6H-Purin-6-one; 9-β-D-ribofuranosyl-Hypoxanthine; 9-β-D-Ribofuranosylhypoxanthine; Inosie; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxyméthyl)tétrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one; INO 495; hypoxanthine; Oxiamin; 9-b-D-Ribofuranosylhypoxanthine; Atorel; MFCD00066770; 9β-D-Ribofuranosylhypoxanthine; 6-oxy-purine riboside; 9-β-D-ribofuranosyl-1,9-dihydro-6H-purin-6-one; 9-b-D-ribofuranosyl-Hypoxanthine; Inosine; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one; T56 BN DN FN HNJ IQ D- BT5OTJ CQ DQ E1Q &&β-D-Ribo Form; Selfer |
| Molecular Formula | C10H12N4O5 |
| Molecular Weight | 268.226 |
| Purity | 99.00 |
| Density | 2.1±0.1 g/cm3 |
| Boiling Point | 670.5±65.0 °C at 760 mmHg |
| Melting Point | 222-226 °C (dec.)(lit.) |
| Appearance | white powder |
| Water Solubility | 2.1 g/100 mL (20 ºC) |
| Storage Condition | This product should be sealed and stored in a cool |
| Application | Inosine is an endogenous purine nucleoside with immunomodulatory, neuroprotective, analgesic and other properties. |
| EINECS | 200-390-4 |
| HTC | 2934999090 |
| SMILES | OCC1OC(C(O)C1O)n2cnc3C(=O)N=CNc23 |
| InChI | InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18) |
| InChI Key | InChIKey=UGQMRVRMYYASKQ-UHFFFAOYSA-N |
| Hazard Symbols | Transport |
| Safety Description | S24/25 |
| MSDS | msds/16786_1_58_63_9.pdf |
| Bioactivity | Inosine, an endogenous purine nucleoside, has immunomodulatory, neuroprotective, and analgesic properties. In vitro: Inosine has been shown to stimulate axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models.[1] Inosine dose-dependently stimulates cAMP production mediated through the A2AR. Inosine dose-dependently induces A2AR-mediated ERK1/2 phosphorylation.[2] In vivo: The reference for Inosine is 1 or 10 mg/kg, i.p. Preventive treatment with inosine inhibits the development and progression of EAE in C57Bl/6 mice. neuroinflammation and demyelinating processes are blocked by inosine treatment. Additionally, inosine consistently inhibits IL-17 levels in peripheral lymphoid tissue, as well as IL-4 levels and A2AR up-regulation in the spinal cord, likely, through an ERK1-independent pathway. [3] inosine acting through adenosine receptors (ARs) exerts a wide range of anti-inflammatory and immunomodulatory effects in vivo. [2] Related Catalog Natural Products >> Others Research Areas >> Others Target Human Endogenous Metabolite References [1]. Moore TL et al. Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey. Restor Neurol Neurosci. 2016 Aug 1. [2]. Welihinda AA et al. The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias. Cell Signal. 2016 Jun;28(6):552-60. [3]. Junqueira SC et al. Inosine, an Endogenous Purine Nucleoside, Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis: a Role for A2A Adenosine Receptor. Mol Neurobiol. 2016 Apr 30. Chemical & Physical Properties Density 2.1±0.1 g/cm3 Boiling Point 670.5±65.0 °C at 760 mmHg Melting Point 222-226 °C (dec.)(lit.) Molecular Formula C10H12N4O5 Molecular Weight 268.226 Flash Point 359.3±34.3 °C Exact Mass 268.080780 PSA 133.49000 LogP -1.91 Vapour Pressure 0.0±2.2 mmHg at 25°C Index of Refraction 1.879 Water Solubility 2.1 g/100 mL (20 ºC) |
| Use of | Properties Articles138 Name inosine Synonym More Synonyms Inosine Biological Activity Related Catalog Natural Products >> Others Research Areas >> Others Human Endogenous Metabolite References [1]. Moore TL et al. Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey. Restor Neurol Neurosci. 2016 Aug 1. [2]. Welihinda AA et al. The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias. Cell Signal. 2016 Jun;28(6):552-60. [3]. Junqueira SC et al. Inosine, an Endogenous Purine Nucleoside, Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis: a Role for A2A Adenosine Receptor. Mol Neurobiol. 2016 Apr 30. Chemical & Physical Properties Molecular Formula C10H12N4O5 Exact Mass 268.080780 PSA 133.49000 LogP -1.91 Index of Refraction 1.879 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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