| Chemical & Physical Properties | |
|---|---|
| CAS Number | 131796-63-9 |
| Catalog No. | 2A-9011745 |
| Chinese Name | Odapipam |
| Synonyms | Odapipam; Nnc 756; UNII-847PQF7ZN6 |
| Molecular Formula | C19H20ClNO2 |
| Molecular Weight | 329.82100 |
| Purity | 98.00 |
| Density | 1.269g/cm3 |
| Boiling Point | 460.4ºC at 760mmHg |
| Application | Odapipam (NNC 756) is a selective, high-affinity benzazepine dopamine D1 receptor antagonist with a Kd of 0.18 nM. Odapipam is also an excellent radiotracer for positron emission tomography (PET). |
| HTC | 2934999090 |
| SMILES | CN1CCc2cc(Cl)c(O)cc2C(c2cccc3c2OCC3)C1 |
| InChI | InChI=1S/C19H20ClNO2/c1-21-7-5-13-9-17(20)18(22)10-15(13)16(11-21)14-4-2-3-12-6-8-23-19(12)14/h2-4,9-10,16,22H,5-8,11H2,1H3/t16-/m1/s1 |
| InChI Key | SKMVRXPBCSTNKE-MRXNPFEDSA-N |
| Use of | Odapipam (NNC 756) is a selective, high affinity and benzazepine dopamine D1 receptor antagonist with a Kd of 0.18 nM. Odapipam is also a superior positron emission tomography (PET) radiotracer[1][2]. Properties Name (5S)-8-chloro-5-(2,3-dihydro-1-benzofuran-7-yl)-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Synonym More Synonyms Odapipam Biological Activity Description Odapipam (NNC 756) is a selective, high affinity and benzazepine dopamine D1 receptor antagonist with a Kd of 0.18 nM. Odapipam is also a superior positron emission tomography (PET) radiotracer[1][2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Dopamine D1 receptor[1] In Vivo The metabolism of Odapipam has been studied with phenobarbital-induced rat liver microsomes. During the incubation of Odapipam, five different metabolites are formed. The electron-ionization (EI+) mass spectra of the metabolites indicated the formation of N-desmethyl-Odapipam, 1-hydroxy-Odapipam, the two isomers of 3′-hydroxy-Odapipam and a metabolite which is dehydrogenated in the dihydrobenzofuran moiety[3]. References [2]. Nielsen EB, et al. Dopamine receptor occupancy in vivo: behavioral correlates using NNC-112, NNC-687 and NNC-756, new selective dopamine D1 receptor antagonists. Eur J Pharmacol. 1992 Aug 14;219(1):35-44. [3]. J. VANGGAARD ANDERSEN, et al. Normal-phase liquid chromatography-particle-beam mass spectrometry in drug metabolism studies of the dopamine receptor antagonist Odapipam and the muscarine M1 receptor agonist Xanomeline. Xenobiotica. 1997, 27: 901-912. Chemical & Physical Properties Exact Mass 329.11800 PSA 32.70000 LogP 3.53820 Index of Refraction 1.623 InChIKey SKMVRXPBCSTNKE-MRXNPFEDSA-N Safety Information HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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