CAS Number54-42-2
Synonyms5-Iodo-2'-desoxyuridine; UNII-LGP81V5245; Dendrid (Trade name); 5-Iodo-2'-Deoxyuridine; Idoxene; Idulea; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-iodo-2,4(1H,3H)-pyrimidinedione; idoxuridine; STOXIL; Ophthalmadine; HERPLEX; EINECS 200-207-8; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-iodpyrimidin-2,4(1H,3H)-dion; Kerecid; 2′-Deoxy-5-iodouridine; 2'-Deoxy-5-iodouridine; Virudox; 5-Iodo-2′-deoxyuridine; MFCD00134656; Iduridin
Molecular FormulaC9H11IN2O5
Molecular Weight354.10
Purity≥99 (HPLC)%
Density2.1±0.1 g/cm3
Melting Point194 °C (lit.)
Appearancepowder or crystals
EINECS200-207-8
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 54-42-2 |
| Catalog No. | 2A-9016664 |
| Chinese Name | 碘苷 |
| Synonyms | 5-Iodo-2'-desoxyuridine; UNII-LGP81V5245; Dendrid (Trade name); 5-Iodo-2'-Deoxyuridine; Idoxene; Idulea; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-iodo-2,4(1H,3H)-pyrimidinedione; idoxuridine; STOXIL; Ophthalmadine; HERPLEX; EINECS 200-207-8; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-iodpyrimidin-2,4(1H,3H)-dion; Kerecid; 2′-Deoxy-5-iodouridine; 2'-Deoxy-5-iodouridine; Virudox; 5-Iodo-2′-deoxyuridine; MFCD00134656; Iduridin |
| Molecular Formula | C9H11IN2O5 |
| Molecular Weight | 354.10 |
| Purity | ≥99 (HPLC) |
| Density | 2.1±0.1 g/cm3 |
| Melting Point | 194 °C (lit.) |
| Appearance | powder or crystals |
| Water Solubility | 1.6 g/L (20 ºC) |
| Storage Condition | This product should be sealed at 4 ℃ to dry and ke |
| Application | The IC50 of Idoxuridine against feline herpesvirus type 1 is 4.3 μM. |
| EINECS | 200-207-8 |
| HTC | 2934999090 |
| PubChem ID | 57654307 |
| MDL Number | MFCD00134656 |
| SMILES | OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(I)C(=O)NC2=O |
| InChI | 1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 |
| InChI Key | XQFRJNBWHJMXHO-RRKCRQDMSA-N |
| Beilstein/REAXYS | 30397 |
| NACRES Code | NA.51 |
| UNSPSC | 41106305 |
| Hazard Symbols | Transport |
| Risk Codes | R45;R46;R61 |
| Safety Description | S53;S45 |
| MSDS | msds/16664_1_54_42_2.pdf |
| Bioactivity | Idoxuridine is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.Target: herpesvirus type-1Idoxuridine is mainly used topically to treat herpes simplex keratitis. Epithelial lesions, especially initial attacks presenting with a dendritic ulcer, are most responsive to therapy, while infection with stromal involvement are less responsive. Idoxuridine is ineffective against herpes simplex virus type 2 and varicella-zoster. Related Catalog Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection References [1]. Seth AK, et al. Topical liposomal gel of idoxuridine for the treatment of herpes simplex: pharmaceutical and clinical implications.Pharm Dev Technol. 2004 Aug;9(3):277-89. [2]. Fauth E, et al. Comparison of spontaneous and idoxuridine-induced micronuclei by chromosome painting. Mutat Res. 1999 Apr 6;440(2):147-56. [3]. Otto SE. Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine). J Intraven Nurs. 1998 Nov-Dec;21(6):335-7. Chemical & Physical Properties Density 2.1±0.1 g/cm3 Melting Point 194 °C(lit.) Molecular Formula C9H11IN2O5 Molecular Weight 354.099 Exact Mass 353.971252 PSA 104.55000 LogP -0.52 Index of Refraction 1.715 InChIKey XQFRJNBWHJMXHO-RRKCRQDMSA-N SMILES O=c1[nH]c(=O)n(C2CC(O)C(CO)O2)cc1I Water Solubility 1.6 g/L (20 ºC) |
| Use of | Idoxuridine is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.Target: herpesvirus type-1Idoxuridine is mainly used topically to treat herpes simplex keratitis. Epithelial lesions, especially initial attacks presenting with a dendritic ulcer, are most responsive to therapy, while infection with stromal involvement are less responsive. Idoxuridine is ineffective against herpes simplex virus type 2 and varicella-zoster. Properties Articles54 Name 5-iodo-2'-deoxyuridine Synonym More Synonyms idoxuridine Biological Activity Description Idoxuridine is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.Target: herpesvirus type-1Idoxuridine is mainly used topically to treat herpes simplex keratitis. Epithelial lesions, especially initial attacks presenting with a dendritic ulcer, are most responsive to therapy, while infection with stromal involvement are less responsive. Idoxuridine is ineffective against herpes simplex virus type 2 and varicella-zoster. Related Catalog Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection References [1]. Seth AK, et al. Topical liposomal gel of idoxuridine for the treatment of herpes simplex: pharmaceutical and clinical implications.Pharm Dev Technol. 2004 Aug;9(3):277-89. [2]. Fauth E, et al. Comparison of spontaneous and idoxuridine-induced micronuclei by chromosome painting. Mutat Res. 1999 Apr 6;440(2):147-56. [3]. Otto SE. Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine). J Intraven Nurs. 1998 Nov-Dec;21(6):335-7. Chemical & Physical Properties Molecular Formula C9H11IN2O5 Exact Mass 353.971252 PSA 104.55000 LogP -0.52 Index of Refraction 1.715 InChIKey XQFRJNBWHJMXHO-RRKCRQDMSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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