EN
0
Home > Products > Pharmaceuticals & Life Science > Biotechnology & Diagnostics > 5-Fluorouridine
5-Fluorouridine structure, CAS 316-46-1

5-Fluorouridine

CAS Number316-46-1

SynonymsL-5-Fluorouridine; FURD; 5-fluoro-uridine; FUR; 5-FLUOROIDINE; 5-fur; 5-Fluor-uridin; EINECS 206-260-3; MFCD00036832; 5-Fluorouridine; 5-FUrd; 5-fluoro-uridin; 1-(β-D-Ribofuranosyl)-5-fluorouracil; FLUOROURIDINE; 5-FU

Molecular FormulaC9H11FN2O6

Molecular Weight262.19

Purity≥99 (HPLC)%

Density1.8±0.1 g/cm3

Boiling Point

Melting Point182-184 °C

Flash Point

Appearancepowder

EINECS206-260-3

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9021232 Purity: ≥99 (HPLC)%
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 316-46-1 ] Purity: ≥99 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number316-46-1
Catalog No.2A-9021232
Chinese Name5-氟尿嘧啶核苷
SynonymsL-5-Fluorouridine; FURD; 5-fluoro-uridine; FUR; 5-FLUOROIDINE; 5-fur; 5-Fluor-uridin; EINECS 206-260-3; MFCD00036832; 5-Fluorouridine; 5-FUrd; 5-fluoro-uridin; 1-(β-D-Ribofuranosyl)-5-fluorouracil; FLUOROURIDINE; 5-FU
Molecular FormulaC9H11FN2O6
Molecular Weight262.19
Purity≥99 (HPLC)
Density1.8±0.1 g/cm3
Melting Point182-184 °C
Appearancepowder
Water Solubilitysoluble
Storage ConditionRoom temperature, sealed, dry
Application5-Fluorouridine is a metabolite of 5-fluorouracil and has anticancer activity. 5-Fluorouridine inhibits rRNA synthesis in human colon cancer cells. 5-Fluorouridine has a cytotoxic effect on the growth
EINECS206-260-3
HTC2942000000
PubChem ID24894883
MDL NumberMFCD00036832
SMILESOC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=C(F)C(=O)NC2=O
InChI1S/C9H11FN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1
InChI KeyFHIDNBAQOFJWCA-UAKXSSHOSA-N
Beilstein/REAXYS33662
NACRES CodeNA.51
UNSPSC41106305
Hazard SymbolsTransport
MSDSmsds/21232_1_316_46_1.pdf
Bioactivity5-Fluorouridine is a metabolite of 5-fluorouracil with anticancer activity[1][2][3][4]. 5-fluorouridine inhibits rRNA synthesis of human colon carcinoma cells[3]. 5-Fluorouridine exhibits cytotoxic effect on growth of L1210 cells with an IC50 of 2 nM[4]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others References [1]. Wu FL , et al. Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2'-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics. Cancer Lett. 2015 Jul 10;363(1):7-16. [2]. Hu N, et al. Strengthening Gastric Cancer Therapy by Trastuzumab-Conjugated Nanoparticles with Simultaneous Encapsulation of Anti-MiR-21 and 5-Fluorouridine. Cell Physiol Biochem. 2017;44(6):2158-2173. [3]. Glazer RI, et al. Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture. Mol Pharmacol. 1982 Mar;21(2):468-73. [4]. Kanzawa F, et al. Differences between 5-fluoro-2'-deoxyuridine and 5-fluorouridine in their cytotoxic effect on growth of murine lymphoma L5178Y cells in in vivo and in vitro systems. Eur J Cancer. 1980 Aug;16(8):1087-92. Chemical & Physical Properties Density 1.8±0.1 g/cm3 Melting Point 182-184 °C Molecular Formula C9H11FN2O6 Molecular Weight 262.192 Exact Mass 262.060120 PSA 124.78000 LogP -1.34 Index of Refraction 1.641 InChIKey FHIDNBAQOFJWCA-UAKXSSHOSA-N SMILES O=c1[nH]c(=O)n(C2OC(CO)C(O)C2O)cc1F Water Solubility soluble
Use ofProperties Articles38 Name 5-fluorouridine Synonym More Synonyms 5-Fluorouridine Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others References [1]. Wu FL , et al. Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2'-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics. Cancer Lett. 2015 Jul 10;363(1):7-16. [2]. Hu N, et al. Strengthening Gastric Cancer Therapy by Trastuzumab-Conjugated Nanoparticles with Simultaneous Encapsulation of Anti-MiR-21 and 5-Fluorouridine. Cell Physiol Biochem. 2017;44(6):2158-2173. [3]. Glazer RI, et al. Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture. Mol Pharmacol. 1982 Mar;21(2):468-73. [4]. Kanzawa F, et al. Differences between 5-fluoro-2'-deoxyuridine and 5-fluorouridine in their cytotoxic effect on growth of murine lymphoma L5178Y cells in in vivo and in vitro systems. Eur J Cancer. 1980 Aug;16(8):1087-92. Chemical & Physical Properties Molecular Formula C9H11FN2O6 Exact Mass 262.060120 PSA 124.78000 LogP -1.34 Index of Refraction 1.641 InChIKey FHIDNBAQOFJWCA-UAKXSSHOSA-N SMILES O=c1[nH]c(=O)n(C2OC(CO)C(O)C2O)cc1F Water Solubility soluble
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
Related Products in Biotechnology & Diagnostics
Floxuridine50-91-92A-9016586
Triphosphopyridine nucleotide53-59-82A-9016651
(+)-5-Iodo-2'-deoxyuridine54-42-22A-9016664
Inosine58-63-92A-9016786
Broxuridine59-14-32A-9016804
2',3'-O-Isopropylideneadenosine362-75-42A-9021503
2',3'-O-Isopropylideneguanosine362-76-52A-9021504
beta-Nicotinamide adenine dinucleotide disodium salt606-68-82A-9024041
5-Iodo-2'-deoxycytidine611-53-02A-9024139
2'-Deoxyadenosine 5'-phosphate653-63-42A-9024746
Browse all Biotechnology & Diagnostics products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA