CAS Number7085-55-4
Synonyms7,3',4'-Tris[O-(2-hydroxyethyl)]rutin; Posorutin; Venoruton P-4; Rufen P-4; Tri(hydroxyethyl)rutoside; Venoruton P4; Trioxyethylrutin; Venoruton; VASTRIBIL; MFCD00893813; Z-6000; Vitamin P4; 7,3',4'-trihydroxyethyl rutin; Troxerutin; Troxerutine; Factor-P-zyma; T66 BO EVJ CR CO2Q DO2Q& GQ IO2Q DO- BT6OTJ CQ DQ EQ F1O-BT6OTJ CQ DQ EQ FQ &&Stereoisomer; RUVEN; EINECS 230-389-4; troxerutina
Molecular FormulaC33H42O19
Molecular Weight742.68
Purity80%
Density1.7±0.1 g/cm3
Boiling Point1058.4±65.0 °C at 760 mmHg
Melting Point168 - 176ºC
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 7085-55-4 |
| Catalog No. | 2A-9012868 |
| Chinese Name | 曲克芦丁 |
| Synonyms | 7,3',4'-Tris[O-(2-hydroxyethyl)]rutin; Posorutin; Venoruton P-4; Rufen P-4; Tri(hydroxyethyl)rutoside; Venoruton P4; Trioxyethylrutin; Venoruton; VASTRIBIL; MFCD00893813; Z-6000; Vitamin P4; 7,3',4'-trihydroxyethyl rutin; Troxerutin; Troxerutine; Factor-P-zyma; T66 BO EVJ CR CO2Q DO2Q& GQ IO2Q DO- BT6OTJ CQ DQ EQ F1O-BT6OTJ CQ DQ EQ FQ &&Stereoisomer; RUVEN; EINECS 230-389-4; troxerutina |
| Molecular Formula | C33H42O19 |
| Molecular Weight | 742.68 |
| Purity | 80 |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 1058.4±65.0 °C at 760 mmHg |
| Melting Point | 168 - 176ºC |
| Appearance | solid |
| Water Solubility | Water solubility: soluble; insoluble: benzene, eth |
| Storage Condition | Refrigerator |
| Application | Troxerutin, also known as vitamin P4, is a trihydroxyethylated derivative of the natural bioflavonoid rutin, which inhibits the production of reactive oxygen species (ROS) and inhibits ER stress-media |
| HTC | 2932999099 |
| MDL Number | MFCD00893813 |
| SMILES | C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](OC3=C(Oc4cc(OCCO)cc(O)c4C3=O)c5ccc(OCCO)c(OCCO)c5)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O |
| InChI | 1S/C33H42O19/c1-14-23(38)26(41)28(43)32(49-14)48-13-21-24(39)27(42)29(44)33(51-21)52-31-25(40)22-17(37)11-16(45-7-4-34)12-20(22)50-30(31)15-2-3-18(46-8-5-35)19(10-15)47-9-6-36/h2-3,10-12,14,21,23-24,26-29,32-39,41-44H,4-9,13H2,1H3/t14-,21+,23-,24+,26+,27-,28+,29+,32+,33-/m0/s1 |
| InChI Key | IYVFNTXFRYQLRP-VVSTWUKXSA-N |
| Beilstein/REAXYS | 4778232 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/12868_1_7085_55_4.pdf |
| Use of | Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation. Properties Articles29 Name troxerutin Synonym More Synonyms Troxerutin Biological Activity Description Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation. Related Catalog Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Natural Products >> Flavonoids Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Research Areas >> Neurological Disease ROS[1], NOD[2] In Vivo Troxerutin effectively lowers body weight and obesity-related metabolic parameters in high-fat diet (HFD)-treated mice. Oral administration of Troxerutin notably inhibits those liver injuries in HFD-treated mice, restores glucose intolerance and insulin signaling, and diminishes hepatic gluconeogenesis in HFD-treated mice. Troxerutin remarkably inhibits the nuclear translocation of NF-κB p65, as well as the expressions of its target genes, in the livers of HFD-treated mice. Troxerutin also depresses endoplasmic reticulum (ER) stress-mediated Nucleotide oligomerization domain (NOD) activation in HFD-treated mouse livers[2]. Lipid depositions in tunica intimae and tunica media are attenuated in Troxerutin-treated diabetic rats compare with untreated diabetic rats. Structural disarrangement and deformity of smooth muscle cells in aortic tissue of Troxerutin-treated diabetic rats are considerably lower than histology of untreated diabetic aorta. Administration of Troxerutin for four weeks to diabetic rats significantly reduces the level of malondialdehyde (MDA) compare to that of untreated diabetic rats (P<0.01)[3]. References [1]. Lim KM, et al. Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells. Mol Med Rep. 2015 Aug;12(2):2650-60. [2]. Zhang Z, et al. Troxerutin Attenuates Enhancement of Hepatic Gluconeogenesis by Inhibiting NOD Activation-Mediated Inflammation in High-Fat Diet-Treated Mice. Int J Mol Sci. 2016 Dec 25;18(1). pii: E31. [3]. Badalzadeh R, et al. Beneficial effect of troxerutin on diabetes-induced vascular damages in rat aorta: histopathological alterations and antioxidation mechanism. Int J Endocrinol Metab. 2015 Apr 30;13(2):e25969. Chemical & Physical Properties Molecular Formula C33H42O19 Exact Mass 742.232056 PSA 297.12000 LogP -0.32 Index of Refraction 1.690 InChIKey IYVFNTXFRYQLRP-VVSTWUKXSA-N Storage condition Refrigerator Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Flavone, 3,5-dihydroxy-3',4',7-tris(2-hydroxyethoxy)-, 3-(6-O-(6-deoxy-alpha-L- mannopyranosyl)-beta-D-glucopyranoside) CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C33-H42-O19 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Cardiac - arrhythmias (including changes in conduction) Cardiac - cardiomegaly Nutritional and Gross Metabolic - body temperature decrease REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 20,879,1965 Safety Information Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter Hazard Codes Xi RIDADR NONH for all modes of transport WGK Germany 3 RTECS LK8331500 HS Code 2932999099 Synthetic Route Total: 1 Page ETHYLENE OXIDE CAS#:75-21-8 CAS#:153-18-4 Troxerutin CAS#:7085-55-4 Literature: Chinese Chemical Letters, , vol. 24, # 3 p. 223 - 226 CAS#:153-18-4 2-Chloroethanol CAS#:107-07-3 Troxerutin CAS#:7085-55-4 Literature: Archiv der Pharmazie, , vol. 318, # 8 p. 747 - 753 Precursor & DownStream Precursor 3 CAS#:75-21-8 ETHYLENE OXIDE CAS#:153-18-4 CAS#:107-07-3 2-Chloroethanol DownStream 1 CAS#:23077-88-5 2-[3,4-dihydrox... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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