CAS Number68786-66-3
SynonymsFasinex; MFCD00864519; Triclabendazole; 6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole; 5-Chloro-6-(2,3-dichlorophenoxy)-2-(methylsulfanyl)-1H-benzimidazole; 5-Chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole
Molecular FormulaC14H9Cl3N2OS
Molecular Weight359.66
Purity98%
Density1.6±0.1 g/cm3
Boiling Point495.9±55.0 °C at 760 mmHg
Melting Point175-176°C
AppearanceWhite to brown crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 68786-66-3 |
| Catalog No. | 2A-9012823 |
| Chinese Name | 三氯苯达唑 |
| Synonyms | Fasinex; MFCD00864519; Triclabendazole; 6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole; 5-Chloro-6-(2,3-dichlorophenoxy)-2-(methylsulfanyl)-1H-benzimidazole; 5-Chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole |
| Molecular Formula | C14H9Cl3N2OS |
| Molecular Weight | 359.66 |
| Purity | 98 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 495.9±55.0 °C at 760 mmHg |
| Melting Point | 175-176°C |
| Appearance | White to brown crystalline powder |
| Storage Condition | Store in a sealed container in a cool, dry place. |
| Application | Triclabendazole (CGA89317) is a benzimidazole that binds to tubulin, impairs intracellular transport mechanisms, and interferes with protein synthesis. |
| HTC | 2933990090 |
| PubChem ID | 329754333 |
| MDL Number | MFCD00864519 |
| SMILES | CSc1nc2cc(Cl)c(Oc3cccc(Cl)c3Cl)cc2[nH]1 |
| InChI | 1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19) |
| InChI Key | NQPDXQQQCQDHHW-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/12823_1_68786_66_3.pdf |
| Bioactivity | Triclabendazole(CGA89317) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.Target: Microtubule/TubulinTriclabendazole treatment produces percentage decreases of the fluke egg output by 15.3%, 4.3% and 36.6%, respectively, in sheep, dairy cows and heifers, these results indicate the presence of TCBZ-resistant Fasciola hepatica in sheep and cattle on this farm [1]. Triclabendazole sulphoxide (50 mg/mL) results in extensive damage to the tegument of triclabendazole-susceptible F. hepatica, whereas triclabendazole-resistant flukes shows only localized and relatively minor disruption of the tegument covering the spines [2].Triclabendazole is metabolized into a number of compounds, depending on the route of administration, plasma levels peak at 18-24 hours (Triclabendazole sulphoxide) and 36-48 hours (Triclabendazole sulphone), neither Triclabendazole nor any toher metabolites can be detected in plasma. Triclabendazole sulphoxide blocks the transport of secretory bodies from the cell body to the tegumental surface, the block occurs at the site of their formation by the Golgi complex in the cell body, in their movement through the cytoplasmic connections to the syncytium, and in their movement from the base to the apex of the syncytium. Triclabendazole binds to the colchicine binding site on the β-tubulin molecule and this has been used at the basis for evaluating the relative acitvity of Triclabendazole [3]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Infection References [1]. Moll, L., et al., Resistance of Fasciola hepatica against triclabendazole in cattle and sheep in The netherlands. Vet Parasitol, 2000. 91(1-2): p. 153-8. [2]. Robinson, M.W., et al., Triclabendazole-resistant Fasciola hepatica: beta-tubulin and response to in vitro treatment with triclabendazole. Parasitology, 2002. 124(Pt 3): p. 325-38. [3]. Fairweather, I., Triclabendazole: new skills to unravel an old(ish) enigma. J Helminthol, 2005. 79(3): p. 227-34. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 495.9±55.0 °C at 760 mmHg Melting Point 175-176°C Molecular Formula C14H9Cl3N2OS Molecular Weight 359.658 Flash Point 253.7±31.5 °C Exact Mass 357.950104 PSA 63.21000 LogP 5.97 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.724 InChIKey NQPDXQQQCQDHHW-UHFFFAOYSA-N SMILES CSc1nc2cc(Oc3cccc(Cl)c3Cl)c(Cl)cc2[nH]1 Stability Stability |
| Use of | Properties Articles38 Name Triclabendazole Synonym More Synonyms Triclabendazole Biological Activity Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Infection References [1]. Moll, L., et al., Resistance of Fasciola hepatica against triclabendazole in cattle and sheep in The netherlands. Vet Parasitol, 2000. 91(1-2): p. 153-8. [2]. Robinson, M.W., et al., Triclabendazole-resistant Fasciola hepatica: beta-tubulin and response to in vitro treatment with triclabendazole. Parasitology, 2002. 124(Pt 3): p. 325-38. [3]. Fairweather, I., Triclabendazole: new skills to unravel an old(ish) enigma. J Helminthol, 2005. 79(3): p. 227-34. Chemical & Physical Properties Exact Mass 357.950104 PSA 63.21000 Index of Refraction 1.724 InChIKey NQPDXQQQCQDHHW-UHFFFAOYSA-N Stability Stability |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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