CAS Number120210-48-2
SynonymsTENIDAP; Tenidapum; (3Z)-5-chloro-3-[hydroxy(thiophen-2-yl)methylidene]-2-oxoindole-1-carboxamide; IL-6+Tenidap; (3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide CP 66248
Molecular FormulaC14H9ClN2O3S
Molecular Weight320.76
Purity98%
Density1.58g/cm3
Boiling Point523.9ºC at 760mmHg
Melting Point230° (dec)
Appearancefaint yellow to dark yellow
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 120210-48-2 |
| Catalog No. | 2A-9012623 |
| Chinese Name | 替尼达普 |
| Synonyms | TENIDAP; Tenidapum; (3Z)-5-chloro-3-[hydroxy(thiophen-2-yl)methylidene]-2-oxoindole-1-carboxamide; IL-6+Tenidap; (3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide CP 66248 |
| Molecular Formula | C14H9ClN2O3S |
| Molecular Weight | 320.76 |
| Purity | 98 |
| Density | 1.58g/cm3 |
| Boiling Point | 523.9ºC at 760mmHg |
| Melting Point | 230° (dec) |
| Appearance | faint yellow to dark yellow |
| Water Solubility | DMSO: soluble1mg/mL, clear (warmed) |
| Storage Condition | Store at +4°C |
| Application | Tenidap is a non-steroidal anti-inflammatory drug and a selective inhibitor of COX-1. Its IC50 values for COX-1 and COX-2 are 0.03 µM and 1.2 µM respectively. Tenidap has anti-inflammatory and anti- |
| MDL Number | MFCD00865996 |
| SMILES | NC(=O)n1c(O)c(C(=O)c2cccs2)c2cc(Cl)ccc21 |
| InChI | InChI=1S/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10/h1-6,19H,(H2,16,20) |
| InChI Key | IZSFDUMVCVVWKW-UHFFFAOYSA-N |
| Hazard Symbols | Transport |
| MSDS | msds/12623_1_120210_48_2.pdf |
| Bioactivity | Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Target COX-1:0.03 μM (IC50) COX-2:1.2 μM (IC50) References [1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. [2]. Blackburn WD Jr, et al. Tenidap in rheumatoid arthritis. A 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone. Arthritis Rheum. 1995 Oct;38(10):1447-56. Chemical & Physical Properties Density 1.58g/cm3 Boiling Point 523.9ºC at 760mmHg Melting Point 230° (dec) Molecular Formula C14H9ClN2O3S Molecular Weight 320.75 Flash Point 270.7ºC Exact Mass 320.00200 PSA 111.87000 LogP 4.01840 Appearance of Characters faint yellow to dark yellow Vapour Pressure 7.42E-13mmHg at 25°C Index of Refraction 1.756 InChIKey IZSFDUMVCVVWKW-UHFFFAOYSA-N SMILES NC(=O)n1c(O)c(C(=O)c2cccs2)c2cc(Cl)ccc21 Storage condition Store at +4°C Water Solubility DMSO: soluble1mg/mL, clear (warmed) |
| Use of | Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. Properties Articles28 Name tenidap Synonym More Synonyms CP-66248 Biological Activity Description Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX COX-1:0.03 μM (IC50) COX-2:1.2 μM (IC50) References [1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. [2]. Blackburn WD Jr, et al. Tenidap in rheumatoid arthritis. A 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone. Arthritis Rheum. 1995 Oct;38(10):1447-56. Chemical & Physical Properties Exact Mass 320.00200 PSA 111.87000 LogP 4.01840 Appearance of Characters faint yellow to dark yellow Index of Refraction 1.756 InChIKey IZSFDUMVCVVWKW-UHFFFAOYSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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