CAS Number15639-50-6
SynonymsMFCD00792847; L-threo sphinganine,2S,3S) L-threo-2-amino-1,3-octadecanediol; L-THREO-DIHYDROSPHINGOSINE
Molecular FormulaC18H39NO2
Molecular Weight301.51
Purity≥95 (TLC)%
Density0.927 g/cm3
Boiling Point446.2ºC at 760 mmHg
Melting Point106.8 - 108.7 °C
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 15639-50-6 |
| Catalog No. | 2A-9012367 |
| Chinese Name | L-苏-二氢鞘氨醇 |
| Synonyms | MFCD00792847; L-threo sphinganine,2S,3S) L-threo-2-amino-1,3-octadecanediol; L-THREO-DIHYDROSPHINGOSINE |
| Molecular Formula | C18H39NO2 |
| Molecular Weight | 301.51 |
| Purity | ≥95 (TLC) |
| Density | 0.927 g/cm3 |
| Boiling Point | 446.2ºC at 760 mmHg |
| Melting Point | 106.8 - 108.7 °C |
| Appearance | powder |
| Storage Condition | 20°C |
| Application | Safingol is a lysophospholipid PKC (protein kinase C) inhibitor [1]. |
| HTC | 2922199090 |
| PubChem ID | 329798800 |
| MDL Number | MFCD00792847 |
| SMILES | CCCCCCCCCCCCCCC[C@H](O)[C@@H](N)CO |
| InChI | 1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18-/m0/s1 |
| InChI Key | OTKJDMGTUTTYMP-ROUUACIJSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352211 |
| MSDS | msds/12367_1_15639_50_6.pdf |
| Bioactivity | Safingol is a lyso-sphingolipid PKC (protein kinase C ) inhibitor[1]. Related Catalog Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> TGF-beta/Smad >> PKC References [1]. Tsukamoto S, et al. Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs. Mol Cancer Ther. 2015 Oct;14(10):2303-12. Chemical & Physical Properties Density 0.927 g/cm3 Boiling Point 446.2ºC at 760 mmHg Melting Point 106.8 - 108.7 °C Molecular Formula C18H39NO2 Molecular Weight 301.50800 Flash Point 223.7ºC Exact Mass 301.29800 PSA 66.48000 LogP 4.84850 Vapour Pressure 7.75E-10mmHg at 25°C Index of Refraction 1.477 InChIKey OTKJDMGTUTTYMP-ROUUACIJSA-N SMILES CCCCCCCCCCCCCCCC(O)C(N)CO Storage condition 20°C |
| Use of | Safingol is a lyso-sphingolipid PKC (protein kinase C ) inhibitor[1]. Properties Articles29 Name L-threo-Dihydrosphingosine Synonym More Synonyms Safingol Biological Activity Description Safingol is a lyso-sphingolipid PKC (protein kinase C ) inhibitor[1]. Related Catalog Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> TGF-beta/Smad >> PKC References [1]. Tsukamoto S, et al. Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs. Mol Cancer Ther. 2015 Oct;14(10):2303-12. Chemical & Physical Properties Molecular Formula C18H39NO2 Exact Mass 301.29800 PSA 66.48000 LogP 4.84850 Index of Refraction 1.477 InChIKey OTKJDMGTUTTYMP-ROUUACIJSA-N SMILES CCCCCCCCCCCCCCCC(O)C(N)CO |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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