CAS Number10338-51-9
SynonymsSALIDROSIDE RHODIOLOSIDE; MFCD00210553; 2-(4-Hydroxyphenyl)ethyl α-D-glucopyranoside; RHODIOLOSIDE; Salisorosides Rosavin; Salidroside; RhodiolaCrenulataExtract; rhodosin; TWEEN 20 EXTRA PURE; β-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl; 2-(4-Hydroxyphenyl)ethyl β-D-glucopyranoside; α-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl; RHODIOLAEXTRACT
Molecular FormulaC14H20O7
Molecular Weight300.30
Purity≥98.0 (HPLC)%
Density1.5±0.1 g/cm3
Boiling Point549.5±50.0 °C at 760 mmHg
AppearanceRed-brown fine powder
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 10338-51-9 |
| Catalog No. | 2A-9012375 |
| Chinese Name | 红景天苷 |
| Synonyms | SALIDROSIDE RHODIOLOSIDE; MFCD00210553; 2-(4-Hydroxyphenyl)ethyl α-D-glucopyranoside; RHODIOLOSIDE; Salisorosides Rosavin; Salidroside; RhodiolaCrenulataExtract; rhodosin; TWEEN 20 EXTRA PURE; β-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl; 2-(4-Hydroxyphenyl)ethyl β-D-glucopyranoside; α-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl; RHODIOLAEXTRACT |
| Molecular Formula | C14H20O7 |
| Molecular Weight | 300.30 |
| Purity | ≥98.0 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 549.5±50.0 °C at 760 mmHg |
| Appearance | Red-brown fine powder |
| Storage Condition | ?20°C |
| Application | Salidroside is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in a mouse model of tumor cachexia through activation of mTOR signaling. |
| HTC | 2932999099 |
| PubChem ID | 329756416 |
| MDL Number | MFCD00210553 |
| SMILES | OC[C@H]1O[C@@H](OCCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O |
| InChI | 1S/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1 |
| InChI Key | ILRCGYURZSFMEG-RKQHYHRCSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 85151701 |
| Hazard Symbols | Transport |
| MSDS | msds/12375_1_10338_51_9.pdf |
| Bioactivity | Salidroside is a prolyl endopeptidase Inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Related Catalog Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Others Natural Products >> Saccharides and Glycosides Target mTOR In Vitro Salidroside (100 μM) inhibits prolyl endopeptidase (PEP) activity (10.6±1.9%). Prolyl endopeptidase is an enzyme that plays a role in the metabolism of proline-containing neuropeptidase which is recognized to be involved in learning and memory[1]. Salidroside, one of the major phenylpropanoid glycosides found in R. rosea L, is consumed almost daily as a nutritional supplement in many countries and has been identified possessing potential anti-fatigue and anoxia,anti-aging, and anti-Alzheimer's disease activities. Salidroside can improve muscle nutrition via increasing mTOR, p-mTOR, and MyHC expression[2]. SH-SY5Y cells are exposed to 0-600 μM MPP+ for 12-48 h and the results show that MPP+ results in a significant decrease of cell viability in a concentration and time-dependent manner. Cells are pretreated with 25-100 μM Salidroside (Sal) for 24 h and then exposed to 500 μM MPP+ for an additional 24 h. Salidroside concentration-dependently prevents MPP+-induced decrease of cell viability. Annexin V/PI staining is a common method for the detection of apoptotic cell. Salidroside significantly decreases the number of Annexin V/PI-stained cells treated by MPP+ which is in a concentration-dependent manner. Apoptotic cell could also be morphologically evaluated by Hoechst staining. In Hoechst staining, apoptotic cells are characterized by reduced nuclear size, chromatin condensation, intense fluorescence, and nuclear fragmentation. Salidroside notably inhibits MPP+-induced increase of chromatin condensation, intense fluorescence, and nuclear fragmentation in SH-SY5Y cells[3]. In Vivo Salidroside is a natural antioxidant extracted from medicinal food plant Rhodiola rosea. Salidroside (100 mg/kg/day) shows strong glucose lowering effect on db/db mice which is similar to effect of Metformin (200 mg/kg/day). For this reason, the dose of 100 mg/kg/day salidroside is used[4]. Cell Assay SH-SY5Y cells are seeded in 96-well plates at 1×104 cells per well. After the treatment with Salidroside (25-100 μM) and MPP+, cell viability is measured by MTT assay. Briefly, cells are incubated with 500 μg/mL MTT at 37°C for 4 h. After that, the medium is removed and 150 μL DMSO is added and shaking is conducted for 10 min. Absorbance is measured at 570 nm in a microplate reader and the results are expressed as folds of control[3]. Animal Admin Mice[4] The 4-week-old male C57BL/6 mice are fed a high-fat diet (HFD) (n=16) or normal chow diet (n=8). After 10 weeks of the HFD, salidroside intervention (100 mg/kg/day) is initiated by gavage once a day for 5 weeks. The control groups are given vehicle (saline). The 4-week-old male C57Bl/KsJ (BKS) mice (wild type, n=8) and BKS.Cg-Dock7m +/+ Leprdb/J (db/db) mice (n=16) are used. Salidroside (100 mg/kg/day) is administrated orally by gavage once a day for 5 weeks. The control groups are given vehicle (saline). Fasting blood glucose and body weight of mice are monitored every 5 days. Glucose measurements are performed on blood drawn from the tail vein using a Glucometer. References [1]. Fan W, et al. Prolyl endopeptidase inhibitors from the underground part of Rhodiola sachalinensis. Chem Pharm Bull (Tokyo). 2001 Apr;49(4):396-401. [2]. Chen X, et al. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activatingmTOR signalling. J Cachexia Sarcopenia Muscle. 2016 May;7(2):225-32. [3]. Wu L, et al. Salidroside Protects against MPP+-Induced Neuronal Injury through DJ-1-Nrf2 Antioxidant Pathway. Evid Based Complement Alternat Med. 2017;2017:5398542. [4]. Ju L, et al. Salidroside, A Natural Antioxidant, Improves β-Cell Survival and Function via Activating AMPK Pathway. Front Pharmacol. 2017 Oct 18;8:749. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 549.5±50.0 °C at 760 mmHg Molecular Formula C14H20O7 Molecular Weight 300.304 Flash Point 286.2±30.1 °C Exact Mass 300.120911 PSA 119.61000 LogP -1.23 Vapour Pressure 0.0±1.6 mmHg at 25°C Index of Refraction 1.629 InChIKey ILRCGYURZSFMEG-RKQHYHRCSA-N SMILES OCC1OC(OCCc2ccc(O)cc2)C(O)C(O)C1O Storage condition ?20°C |
| Use of | Salidroside is a prolyl endopeptidase Inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Properties Articles47 Name Salidroside Synonym More Synonyms Salidroside Biological Activity Description Salidroside is a prolyl endopeptidase Inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Related Catalog Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Others Natural Products >> Saccharides and Glycosides References [1]. Fan W, et al. Prolyl endopeptidase inhibitors from the underground part of Rhodiola sachalinensis. Chem Pharm Bull (Tokyo). 2001 Apr;49(4):396-401. [2]. Chen X, et al. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activatingmTOR signalling. J Cachexia Sarcopenia Muscle. 2016 May;7(2):225-32. [3]. Wu L, et al. Salidroside Protects against MPP+-Induced Neuronal Injury through DJ-1-Nrf2 Antioxidant Pathway. Evid Based Complement Alternat Med. 2017;2017:5398542. [4]. Ju L, et al. Salidroside, A Natural Antioxidant, Improves β-Cell Survival and Function via Activating AMPK Pathway. Front Pharmacol. 2017 Oct 18;8:749. Chemical & Physical Properties Molecular Formula C14H20O7 Exact Mass 300.120911 PSA 119.61000 LogP -1.23 Index of Refraction 1.629 InChIKey ILRCGYURZSFMEG-RKQHYHRCSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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