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Salinomycin sodium structure, CAS 53003-10-4

Salinomycin sodium

CAS Number53003-10-4

SynonymsCoxistac; Antibiotic 61477; salinomycin acid; MFCD00036900; SALINOMYCIN SODIUM; Salinomycin; EINECS 258-290-1; SALINOMYCIN GRANULE; SALINOMYCIN SODIUM SALT; Bio-cox

Molecular FormulaC42H70O11

Molecular Weight751.00

Purity96%

Density1.2±0.1 g/cm3

Boiling Point839.2±65.0 °C at 760 mmHg

Melting Point112.5-113.5 °C(lit.)

Flash Point

Appearancewhite powder

EINECS

MSDSChineseEnglish

Symbol6.1(a)

Signal WordWarning

Cat. No.: 2A-9012376 Purity: 96%
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Quality Control of [ 53003-10-4 ] Purity: 96% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number53003-10-4
Catalog No.2A-9012376
Chinese Name盐霉素
SynonymsCoxistac; Antibiotic 61477; salinomycin acid; MFCD00036900; SALINOMYCIN SODIUM; Salinomycin; EINECS 258-290-1; SALINOMYCIN GRANULE; SALINOMYCIN SODIUM SALT; Bio-cox
Molecular FormulaC42H70O11
Molecular Weight751.00
Purity96
Density1.2±0.1 g/cm3
Boiling Point839.2±65.0 °C at 760 mmHg
Melting Point112.5-113.5 °C(lit.)
Appearancewhite powder
Storage Condition2-8°C
PackagingII
ApplicationSalinomycin is an anticoccidial drug with powerful anti-bacterial activity and a new anti-cancer agent targeting human cancer stem cells.
HTC2309901000
SMILESCCC(C(=O)O)C1CCC(C)C(C(C)C(O)C(C)C(=O)C(CC)C2OC3(C=CC(O)C4(CCC(C)(C5CCC(O)(CC)C(C)O5)O4)O3)C(C)CC2C)O1
InChI KeyKQXDHUJYNAXLNZ-SDCJTGBBSA-N
Hazard Symbols6.1(a)
Use ofSalinomycin is an anticoccidial drug with potent anti-bacterial activity and an novel anticancer agent targeting human cancer stem cells. Properties Articles68 Name Salinomycin Synonym More Synonyms Salinomycin Biological Activity Description Salinomycin is an anticoccidial drug with potent anti-bacterial activity and an novel anticancer agent targeting human cancer stem cells. Related Catalog Signaling Pathways >> Stem Cell/Wnt >> β-catenin Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Bacterial Signaling Pathways >> Autophagy >> Mitophagy Signaling Pathways >> Stem Cell/Wnt >> Wnt Natural Products >> Others Research Areas >> Cancer IC50: 163 nM (Wnt1-stimulated reporter)[1] References [1]. Lu D, et al. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7. [2]. Zhou J, et al. Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactiveoxygen species. Toxicol Lett. 2013 Oct 24;222(2):139-45. [3]. Wang F, et al. Salinomycin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells In Vitro and In Vivo. PLoS One. 2012; 7(12): e50638. [4]. Qu H, et al. Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24. Asian Pac J Trop Med. 2015 Jul;8(7):578-82. Chemical & Physical Properties Molecular Formula C42H70O11 PSA 164.04000 Index of Refraction 1.547 InChIKey KQXDHUJYNAXLNZ-SDCJTGBBSA-N Stability Stable, but may be heat sensitive - keep cool. Incompatible with strong oxidizing agents. Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Salinomycin CAS REGISTRY NUMBER : 53003-10-4 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C42-H70-O11 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T6XOX DHJ DQ A-& BT6OXTJ C1 E1 FY2&VY1&YQY1&- BT6OTJ C1 FY2&VQ&& C-& BT5OXTJ E1 E- FT6OTJ B1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,813,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 31,1,1978 Safety Information Signal Word Danger Hazard Statements H300 Precautionary Statements P264-P301 + P310 Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges Hazard Codes T:Toxic; Risk Phrases R25 Safety Phrases S45 WGK Germany 3 RTECS VO8620000 Packaging Group II Hazard Class 6.1(a) HS Code 2309901000 Synthetic Route Salinomycin sod... 55721-31-8 Salinomycin 53003-10-4 Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 14 p. 4697 - 4702 salinomycin aci... 120330-27-0 Salinomycin 53003-10-4 Literature: Horita; Oikawa; Nagato; Yonemitsu Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 7 p. 1717 - 1725 D-glucopyranose Salinomycin 53003-10-4 Literature: Tetrahedron Letters, , vol. 29, # 40 p. 5143 - 5146 Precursor & DownStream Precursor 7 CAS#:55721-31-8 Salinomycin sod... CAS#:120330-27-0 salinomycin acid CAS#:2280-44-6 D-glucopyranose CAS#:81496-83-5 (S)-3-((4R,5S)-... DownStream 0
Transport InfoProduct Name: Salinomycin
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