CAS Number54187-04-1
SynonymsRilmenidine; S 3341-3; S 3341; N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine; Oxaminozoline; hyperium; N-(Dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine; 2-[N-(Dicyclopropylmethyl)amino]oxazoline; EINECS 259-021-0; Tenaxum; MFCD00865924
Molecular FormulaC10H16N2O
Molecular Weight180.252
Purity98%
Density1.5±0.1 g/cm3
Boiling Point355.5±9.0 °C at 760 mmHg
Melting Point106 - 107ºC
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 54187-04-1 |
| Catalog No. | 2A-9012306 |
| Chinese Name | 利美尼啶 |
| Synonyms | Rilmenidine; S 3341-3; S 3341; N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine; Oxaminozoline; hyperium; N-(Dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine; 2-[N-(Dicyclopropylmethyl)amino]oxazoline; EINECS 259-021-0; Tenaxum; MFCD00865924 |
| Molecular Formula | C10H16N2O |
| Molecular Weight | 180.252 |
| Purity | 98 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 355.5±9.0 °C at 760 mmHg |
| Melting Point | 106 - 107ºC |
| Appearance | solid |
| Water Solubility | H2O: 7.3 mg/mL |
| Storage Condition | Store at -20°C |
| Application | Rilmenidine is a novel antihypertensive drug and orally active selective I1 imidazoline receptor agonist. Rilmenidine is an α2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine can regu |
| HTC | 2934999090 |
| MDL Number | MFCD00865924 |
| SMILES | C1COC(NC(C2CC2)C2CC2)=N1 |
| InChI | InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12) |
| InChI Key | CQXADFVORZEARL-UHFFFAOYSA-N |
| MSDS | msds/12306_1_54187_04_1.pdf |
| Use of | Properties Name N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine Synonym More Synonyms Rilmenidine Biological Activity Related Catalog Signaling Pathways >> Neuronal Signaling >> Imidazoline Receptor Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Imidazoline Receptor Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor In Vivo Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age[3]. References [1]. Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S. [3]. Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19(11):2144-2153. Chemical & Physical Properties Molecular Formula C10H16N2O Exact Mass 180.126266 PSA 33.62000 Index of Refraction 1.711 InChIKey CQXADFVORZEARL-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Oxazolidine, 2-((dicyclopropylmethyl)imino)- CAS REGISTRY NUMBER : 54187-04-1 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C10-H16-N2-O MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T5N CO AUTJ BMY- AL3TJ&- AL3TJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 1 umol/plate REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,527,1983 Safety Information WGK Germany 3 RTECS RP7207400 HS Code 2934999090 Precursor & DownStream Precursor 2 CAS#:54187-44-9 N-(dicyclopropy... CAS#:54187-03-0 3-(2-chloroethy... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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