CAS Number66-97-7
SynonymsFurocoumarin; 7H-Furo[3,2-g]chromen-7-one; Psoralen; EINECS 200-639-7; Psoralene; prosuler; 6,7-Furanocoumarin; MFCD00010520; Psorline-P; FICUSIN; 7H-Furo[3,2-g][1]benzopyran-7-one
Molecular FormulaC11H6O3
Molecular Weight186.16
Purity≥99 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point362.6±27.0 °C at 760 mmHg
Melting Point160-162 °C
Appearancepowder
EINECS200-639-7
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 66-97-7 |
| Catalog No. | 2A-9012193 |
| Chinese Name | 补骨脂素 |
| Synonyms | Furocoumarin; 7H-Furo[3,2-g]chromen-7-one; Psoralen; EINECS 200-639-7; Psoralene; prosuler; 6,7-Furanocoumarin; MFCD00010520; Psorline-P; FICUSIN; 7H-Furo[3,2-g][1]benzopyran-7-one |
| Molecular Formula | C11H6O3 |
| Molecular Weight | 186.16 |
| Purity | ≥99 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 362.6±27.0 °C at 760 mmHg |
| Melting Point | 160-162 °C |
| Appearance | powder |
| Storage Condition | 2-8°C |
| Application | Psoralen (furanocoumarins) is an active ingredient extracted from psoralen and has anti-cancer activity. |
| EINECS | 200-639-7 |
| PubChem ID | 24898918 |
| MDL Number | MFCD00010520 |
| SMILES | O=C1Oc2cc3occc3cc2C=C1 |
| InChI | 1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H |
| InChI Key | ZCCUUQDIBDJBTK-UHFFFAOYSA-N |
| Beilstein/REAXYS | 152784 |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/12193_1_66_97_7.pdf |
| Bioactivity | Psoralen(Furocoumarin) is an active ingredient from Fructus Psoraleae; has anticancer activity.IC50 value:Target:in vitro: Psoralen dosages of 1-10 μM exhibited low cytotoxicity toward chondrocytes. However, a dosage of 100 μM suppressed the proliferation of chondrocytes. Different concentrations of psoralen treatments on chondrocytes revealed that GAG and Type II collagen synthesis increased, especially at 100 μM, by 0.39-fold and 0.48-fold, respectively, on day 3, and by 0.51-fold and 0.56-fold, respectively, on day 9 [1]. in vivo: Tumor volume inhibition rates were 43.75% and 40.18%, respectively, in the psoralen and isopsoralen low-dose groups, and tumor weight inhibition rates were 38.83% and 37.77%. Tumor volume inhibition rates were 67.86% and 66.96%, respectively, in the psoralen and isopsoralen high-dose groups, and tumor weight inhibition rates were 49.47% and 47.87% [2]. psoralen can inhibit metastasis of breast cancer to bone in vivo. Histological, molecular biological, and imaging analyses revealed that psoralen inhibits bone metastases in mice [3]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Phenylpropanoids References [1]. Xu K, et al. Psoralen activates cartilaginous cellular functions of rat chondrocytes in vitro. Pharm Biol. 2014 Dec 4:1-6. [2]. Lu H, et al. Isolation and purification of psoralen and isopsoralen and their efficacy and safety in the treatment of osteosarcoma in nude rats. Afr Health Sci. 2014 Sep;14(3):641-7. [3]. Wu C, et al. Psoralen inhibits bone metastasis of breast cancer in mice. Fitoterapia. 2013 Dec;91:205-10. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 362.6±27.0 °C at 760 mmHg Melting Point 160-162 °C Molecular Formula C11H6O3 Molecular Weight 186.163 Flash Point 173.1±23.7 °C Exact Mass 186.031693 PSA 43.35000 LogP 1.67 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.667 InChIKey ZCCUUQDIBDJBTK-UHFFFAOYSA-N SMILES O=c1ccc2cc3ccoc3cc2o1 Storage condition 2-8°C |
| Use of | Psoralen(Furocoumarin) is an active ingredient from Fructus Psoraleae; has anticancer activity.IC50 value:Target:in vitro: Psoralen dosages of 1-10 μM exhibited low cytotoxicity toward chondrocytes. However, a dosage of 100 μM suppressed the proliferation of chondrocytes. Different concentrations of psoralen treatments on chondrocytes revealed that GAG and Type II collagen synthesis increased, especially at 100 μM, by 0.39-fold and 0.48-fold, respectively, on day 3, and by 0.51-fold and 0.56-fold, respectively, on day 9 [1]. in vivo: Tumor volume inhibition rates were 43.75% and 40.18%, respectively, in the psoralen and isopsoralen low-dose groups, and tumor weight inhibition rates were 38.83% and 37.77%. Tumor volume inhibition rates were 67.86% and 66.96%, respectively, in the psoralen and isopsoralen high-dose groups, and tumor weight inhibition rates were 49.47% and 47.87% [2]. psoralen can inhibit metastasis of breast cancer to bone in vivo. Histological, molecular biological, and imaging analyses revealed that psoralen inhibits bone metastases in mice [3]. Properties Articles66 Name psoralen Synonym More Synonyms Psoralen Biological Activity Description Psoralen(Furocoumarin) is an active ingredient from Fructus Psoraleae; has anticancer activity.IC50 value:Target:in vitro: Psoralen dosages of 1-10 μM exhibited low cytotoxicity toward chondrocytes. However, a dosage of 100 μM suppressed the proliferation of chondrocytes. Different concentrations of psoralen treatments on chondrocytes revealed that GAG and Type II collagen synthesis increased, especially at 100 μM, by 0.39-fold and 0.48-fold, respectively, on day 3, and by 0.51-fold and 0.56-fold, respectively, on day 9 [1]. in vivo: Tumor volume inhibition rates were 43.75% and 40.18%, respectively, in the psoralen and isopsoralen low-dose groups, and tumor weight inhibition rates were 38.83% and 37.77%. Tumor volume inhibition rates were 67.86% and 66.96%, respectively, in the psoralen and isopsoralen high-dose groups, and tumor weight inhibition rates were 49.47% and 47.87% [2]. psoralen can inhibit metastasis of breast cancer to bone in vivo. Histological, molecular biological, and imaging analyses revealed that psoralen inhibits bone metastases in mice [3]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Phenylpropanoids References [1]. Xu K, et al. Psoralen activates cartilaginous cellular functions of rat chondrocytes in vitro. Pharm Biol. 2014 Dec 4:1-6. [2]. Lu H, et al. Isolation and purification of psoralen and isopsoralen and their efficacy and safety in the treatment of osteosarcoma in nude rats. Afr Health Sci. 2014 Sep;14(3):641-7. [3]. Wu C, et al. Psoralen inhibits bone metastasis of breast cancer in mice. Fitoterapia. 2013 Dec;91:205-10. Chemical & Physical Properties Molecular Formula C11H6O3 Exact Mass 186.031693 PSA 43.35000 Index of Refraction 1.667 InChIKey ZCCUUQDIBDJBTK-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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