CAS Number83-48-7
Synonyms(24S)-5,22-Stigmastadien-3b-ol; STIGMASTEROL (STIGMASTERIN); (24S)-Stigmast-5,22-dien-3β-ol; STIGMASTEROL(P); Wulzen anti-stiffness factor; Guinea-pig-anti-stiffness factor; SULFISOXAZOLE; Stigmasta-5,22-dien-3β-ol; Stigmasterol; δ5,22-Stigmastadien-3β-ol; Anti-stiffness factor; (3β,22E)-Stigmasta-5,22-dien-3-ol; MFCD00003630; Stigmasta-5,22E-dien-3β-ol; isofucosterol; stigmasta-5,22-dien-3-b-ol; Stigmastero; EINECS 201-482-7; Stigmasterin; (3β,20R,22E,24S)-Stigmasta-5,22-dien-3-ol; 3b-Hydroxy-24-ethyl-D5,22-cholestadiene; δ5-Stigmasterol; 24S-ethylcholest-5,22-dien-3β-ol; stigmasta-5,22-dien-3-β-ol; β-Stigmasterol; (24S)-5,22-Stigmastadien-3β-ol; (3b,22E)-Stigmasta-5,22-dien-3-ol; 5,22-stigmastadien-3β-ol; PHYTOSTEROL; UNII-99WUK5D0Y8
Molecular FormulaC29H48O
Molecular Weight412.69
Purity~95%
Density1.0±0.1 g/cm3
Boiling Point501.1±19.0 °C at 760 mmHg
Melting Point165-167 °C (lit.)
Appearancewhite solid
EINECS201-482-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 83-48-7 |
| Catalog No. | 2A-9012002 |
| Chinese Name | 豆甾醇 |
| Synonyms | (24S)-5,22-Stigmastadien-3b-ol; STIGMASTEROL (STIGMASTERIN); (24S)-Stigmast-5,22-dien-3β-ol; STIGMASTEROL(P); Wulzen anti-stiffness factor; Guinea-pig-anti-stiffness factor; SULFISOXAZOLE; Stigmasta-5,22-dien-3β-ol; Stigmasterol; δ5,22-Stigmastadien-3β-ol; Anti-stiffness factor; (3β,22E)-Stigmasta-5,22-dien-3-ol; MFCD00003630; Stigmasta-5,22E-dien-3β-ol; isofucosterol; stigmasta-5,22-dien-3-b-ol; Stigmastero; EINECS 201-482-7; Stigmasterin; (3β,20R,22E,24S)-Stigmasta-5,22-dien-3-ol; 3b-Hydroxy-24-ethyl-D5,22-cholestadiene; δ5-Stigmasterol; 24S-ethylcholest-5,22-dien-3β-ol; stigmasta-5,22-dien-3-β-ol; β-Stigmasterol; (24S)-5,22-Stigmastadien-3β-ol; (3b,22E)-Stigmasta-5,22-dien-3-ol; 5,22-stigmastadien-3β-ol; PHYTOSTEROL; UNII-99WUK5D0Y8 |
| Molecular Formula | C29H48O |
| Molecular Weight | 412.69 |
| Purity | ~95 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 501.1±19.0 °C at 760 mmHg |
| Melting Point | 165-167 °C (lit.) |
| Appearance | white solid |
| Water Solubility | insoluble |
| Storage Condition | This product should be sealed and stored in a cool |
| Application | Stigmasterol is a plant-based sterol that not only has cholesterol-lowering activity, but is also evaluated as an anti-sclerotic factor in the treatment of rheumatic diseases. |
| EINECS | 201-482-7 |
| HTC | 2906199090 |
| PubChem ID | 24899523 |
| MDL Number | MFCD00003630 |
| SMILES | [H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)/C=C/[C@@H](CC)C(C)C |
| InChI | 1S/C29H48O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h8-10,19-21,23-27,30H,7,11-18H2,1-6H3/b9-8+/t20-,21-,23+,24+,25-,26+,27+,28+,29-/m1/s1 |
| InChI Key | HCXVJBMSMIARIN-PHZDYDNGSA-N |
| Beilstein/REAXYS | 2568182 |
| NACRES Code | NA.77 |
| UNSPSC | 12352211 |
| Hazard Symbols | Transport |
| MSDS | msds/12002_1_83_48_7.pdf |
| Bioactivity | Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases. Related Catalog Natural Products >> Steroids Research Areas >> Inflammation/Immunology Target MMP[1] In Vitro Preincubation of Stigmasterol to IL-1beta-treated cells shows significant reduction of MMP-3 mRNA in human and mouse, MMP-3 protein in mouse, MMP-13 mRNA in mouse and human, ADAMTS-4 mRNA in human, PGE2 protein in human and mouse. Stigmasterol is also capable of counteracting the IL-1beta-induced NF-κB pathway[1]. Cell Assay A model of newborn mouse chondrocytes and human osteoarthritis (OA) chondrocytes are used in primary culture stimulated with or without IL-1β (10 ng/mL), for 18 h. Cells are pre-incubated with Stigmasterol (20 mg/mL) for 48 h[1]. References [1]. Gabay O, et al. Stigmasterol: a phytosterol with potential anti-osteoarthritic properties. Osteoarthritis Cartilage. 2010 Jan;18(1):106-16. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 501.1±19.0 °C at 760 mmHg Melting Point 165-167 °C(lit.) Molecular Formula C29H48O Molecular Weight 412.691 Flash Point 219.4±13.7 °C Exact Mass 412.370514 PSA 20.23000 LogP 10.21 Vapour Pressure 0.0±2.9 mmHg at 25°C Index of Refraction 1.531 Storage condition 2~8°C Water Solubility insoluble |
| Use of | Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases. Properties Articles68 Name stigmasterol Synonym More Synonyms Stigmasterol Biological Activity Description Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases. Related Catalog Natural Products >> Steroids Research Areas >> Inflammation/Immunology References [1]. Gabay O, et al. Stigmasterol: a phytosterol with potential anti-osteoarthritic properties. Osteoarthritis Cartilage. 2010 Jan;18(1):106-16. Chemical & Physical Properties Molecular Formula C29H48O Exact Mass 412.370514 PSA 20.23000 LogP 10.21 Index of Refraction 1.531 Water Solubility insoluble |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 5.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 97.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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