CAS Number68497-62-1
SynonymsN-[2-[di(propan-2-yl)amino]ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide; Neupramir; Pramiracetam; Pramistar; Remen; Amacetam; N-[2-(Diisopropylamino)ethyl]-2-(2-oxo-1-pyrrolidinyl)acetamide; MFCD00867219; N-[2-(diisopropylamino)ethyl]-2-oxo-1-pyrrolidineacetamide; N-[2-(dipropan-2-ylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide; N-[2-[Bis(1-methylethyl)amino]ethyl]-2-oxo-1-pyrrolidineacetamide; N-[2-(Diisopropylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide
Molecular FormulaC14H27N3O2
Molecular Weight269.38
Purity≥98 (HPLC)%
Density1.0±0.1 g/cm3
Boiling Point461.0±30.0 °C at 760 mmHg
Melting Point47 °C
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 68497-62-1 |
| Catalog No. | 2A-9012095 |
| Chinese Name | 普拉西坦 |
| Synonyms | N-[2-[di(propan-2-yl)amino]ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide; Neupramir; Pramiracetam; Pramistar; Remen; Amacetam; N-[2-(Diisopropylamino)ethyl]-2-(2-oxo-1-pyrrolidinyl)acetamide; MFCD00867219; N-[2-(diisopropylamino)ethyl]-2-oxo-1-pyrrolidineacetamide; N-[2-(dipropan-2-ylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide; N-[2-[Bis(1-methylethyl)amino]ethyl]-2-oxo-1-pyrrolidineacetamide; N-[2-(Diisopropylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide |
| Molecular Formula | C14H27N3O2 |
| Molecular Weight | 269.38 |
| Purity | ≥98 (HPLC) |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 461.0±30.0 °C at 760 mmHg |
| Melting Point | 47 °C |
| Appearance | powder |
| Water Solubility | Soluble in: methanol |
| Storage Condition | 2-8°C |
| Application | Pramiracetam is derived from piracetam and can improve cognitive impairment caused by brain trauma. |
| HTC | 2942000000 |
| SMILES | [S](=O)(=O)([O-])O.[N+H](C(C)C)(C(C)C)CCNC(=O)CN1CCCC1=O |
| InChI | 1S/C14H27N3O2.H2O4S/c1-11(2)17(12(3)4)9-7-15-13(18)10-16-8-5-6-14(16)19;1-5(2,3)4/h11-12H,5-10H2,1-4H3,(H,15,18);(H2,1,2,3,4) |
| InChI Key | ACSROKXFXFNERX-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/12095_1_68497_62_1.pdf |
| Bioactivity | Pramiracetam is a nootropic drug derived from piracetam, and is more potent. Pramiracetam reportedly improved cognitive deficits associated with traumatic brain injuries. IC50 Value: Target: in vitro: Pramiracetam sulfate did not exhibit any affinity in vitro for dopaminergic , GABAergic, serotoninergic, adrenergic, muscarinic, adenosine (IC50 > 10 uM), and benzodiazepine receptors (IC50 > 1 uM) binding sites [1].in vivo: In a double-blind, randomized design, two groups of six subjects each received alternating placebo and single 400, 800, 1,200, and 1,600 mg oral doses of pramiracetam after an overnight fast. Mean (± SD) peak plasma concentrations of the four dose groups (2.71 ± 0.54, 5.40 ± 1.34, 6.13 ± 0.71, 8.98 ± 0.71 micrograms/mL) were attained between two to three hours following drug administration [2]. Two doses of pramiracetam (7.5 mg/kg and 15 mg/kg) were administered daily prior to testing for 7 weeks in a 16-arm radial maze in which nine arms were baited with food [3]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Warner Lambert, et al. Some Neurochemical Properties of Pramiracetam (CI-879), A New Cognition-Enhancing Agent. [2]. Chang T, et al. Pharmacokinetics of oral pramiracetam in normal volunteers. J Clin Pharmacol. 1985 May-Jun;25(4):291-5. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 461.0±30.0 °C at 760 mmHg Melting Point 47 °C Molecular Formula C14H27N3O2 Molecular Weight 269.383 Flash Point 232.6±24.6 °C Exact Mass 269.210327 PSA 52.65000 LogP 0.39 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.495 InChIKey ZULJGOSFKWFVRX-UHFFFAOYSA-N SMILES CC(C)N(CCNC(=O)CN1CCCC1=O)C(C)C Storage condition 2-8°C |
| Use of | Properties Articles23 Name Pramiracetam Hydrate Synonym More Synonyms pramiracetam Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Warner Lambert, et al. Some Neurochemical Properties of Pramiracetam (CI-879), A New Cognition-Enhancing Agent. [2]. Chang T, et al. Pharmacokinetics of oral pramiracetam in normal volunteers. J Clin Pharmacol. 1985 May-Jun;25(4):291-5. Chemical & Physical Properties Molecular Formula C14H27N3O2 Exact Mass 269.210327 PSA 52.65000 Index of Refraction 1.495 InChIKey ZULJGOSFKWFVRX-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 9.0% Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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