CAS Number25655-41-8
SynonymsIsobetadyne; Povidone-iodine; Disphex; Polyvinylpyrrolidone-Iodine Complex; PVP-I; Poly(vinylpyrrolidone)-Iodine complex; MFCD00084483; Povidone (iodinated); EINECS 215-034-3; Poly(vinylpyrrolidone)-Iodine complex; Isodine; Bridine; PVP iodine; Betadine; Povidone Iodine
Molecular FormulaC6H9I2NO
Molecular Weight364.951
Purity98.00%
Boiling Point217.6ºC at 760 mmHg
Melting Point300ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 25655-41-8 |
| Catalog No. | 2A-0201944 |
| Chinese Name | 聚维酮碘 |
| Synonyms | Isobetadyne; Povidone-iodine; Disphex; Polyvinylpyrrolidone-Iodine Complex; PVP-I; Poly(vinylpyrrolidone)-Iodine complex; MFCD00084483; Povidone (iodinated); EINECS 215-034-3; Poly(vinylpyrrolidone)-Iodine complex; Isodine; Bridine; PVP iodine; Betadine; Povidone Iodine |
| Molecular Formula | C6H9I2NO |
| Molecular Weight | 364.951 |
| Purity | 98.00 |
| Boiling Point | 217.6ºC at 760 mmHg |
| Melting Point | 300ºC |
| Appearance | powder |
| Storage Condition | Sealed in a cool, dry environment |
| Application | Povidone iodine shows excellent antibacterial activity and can kill MRSA and MSSA strains with MICs of 31.25 mg/L and 7.82 mg/L respectively. |
| HTC | 3808940010 |
| PubChem ID | 24899316 |
| MDL Number | MFCD00084483 |
| SMILES | II.C=CN1CCCC1=O |
| InChI | 1S/C6H9NO.I2/c1-2-7-5-3-4-6(7)8;1-2/h2H,1,3-5H2; |
| InChI Key | CPKVUHPKYQGHMW-UHFFFAOYSA-N |
| NACRES Code | NA.85 |
| UNSPSC | 51102829 |
| Hazard Symbols | Transport |
| MSDS | msds/12092_1_25655_41_8.pdf |
| Bioactivity | Povidone iodine displays excellent antibacterial activity which can against MRSA and MSSA strains with MICs of 31.25 mg/L and 7.82 mg/L, respectively. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection In Vitro MIC values of Povidone iodine (PVP-I) are 31.25 mg/L and 7.82 mg/L, respectively. Treatment of the cells with Povidone iodine (PVP-I) at a dilution of 1:32 causes a sharp reduction in cell viability by 90-95% on all testing cell lines[1]. In Vivo The Dp+Povidone iodine (PVP-I) group has the second highest average score from day 13 to the end of the experimental period. The Dp+Povidone iodine and Dp+Et-OH groups also show a significantly increase in eosinophil count compare with the control group (p<0.05 and p<0.001, respectively). However, the eosinophil count does not significantly differ among the Dp+Povidone iodine (PVP-I), Dp+CHG, and Dp+vehicle groups[2]. Cell Assay Each bacterial isolate is washed twice with phosphate-buffered saline (PBS, pH 7.2), centrifuged for 10 min at 1932xg at 20°C, and suspended in 3 mL of nutrient broth, adjusted to a turbidity equivalent of 0.5 McFarland standard. The bacterial suspension is diluted 1:100 with MHB to a final inoculum of 106 colony-forming units (cfu)/mL. For each bacterial strain, two rows of a 96-well microtitre plate are filled with the final bacterial inoculum (50 μL per well) and 50 μL of each serial dilution of ILαD. The procedure is repeated for the Povidone iodine (PVP-I) serial dilutions[1]. Animal Admin The mice are divided into 6 groups as follows: 1) saline+vehicle (control group), 2) Dp+vehicle, 3) Dp+BZK, 4) Dp+Povidone iodine (PVP-I), 5) Dp+Et-OH, and 6) Dp+CHG. Animals in the experimental groups are exposed to the allergen through the subcutaneous injection of 5 µg of Dp dissolving in 10 µL of saline in the ventral side of the right ear 2 to 3 days a week (a total of 8 times) under anesthesia with 4% halothane. Animals in the control group are not sensitized, receiving a subcutaneous injection of 10 µL of saline in the ventral side of the right ear. Animals receive an application of antiseptic agent are exposed to the allergen and treated with 0.2% (w/v) benzalkonium chloride (Dp+BZK), 10% (w/v) povidone-iodine (Dp+PVP-I), 80% (v/v) ethanol (Dp+Et-OH) or 0.5% (v/v) chlorhexidine gluconate (Dp+CHG). These agents are applied a total of 15 times during the experimental period. The BZK, Povidone iodine (PVP-I), Et-OH, and CHG are dissolved in 25 µL of injection water and applied gently to the dorsal side of the right ear using a micropipette with a fine plastic tip. The animals in the Dp+vehicle and control groups receive 25 µL of injection water. All animals are sacrificed on the last day of the experiment (day 18)[2]. References [1]. Zisi AP, et al. Iodine-lithium-alpha-dextrin (ILαD) against Staphylococcus aureus skin infections: a comparative study of in-vitro bactericidal activity and cytotoxicity between ILαD and povidone-iodine. J Hosp Infect. 2017 Jul 20. pii: S0195-6701(17)30395-X. [2]. Kaori Sadakane, et al. Effect of the Hand Antiseptic Agents Benzalkonium Chloride, Povidone-Iodine, Ethanol, and Chlorhexidine Gluconate on Atopic Dermatitis in NC/Nga Mice. Int J Med Sci. 2015; 12(2): 116-125. Chemical & Physical Properties Boiling Point 217.6ºC at 760 mmHg Melting Point 300ºC Molecular Formula C6H9I2NO Molecular Weight 364.951 Flash Point 93.9ºC Exact Mass 364.877319 PSA 20.31000 LogP 2.46160 Vapour Pressure 0.132mmHg at 25°C InChIKey CPKVUHPKYQGHMW-UHFFFAOYSA-N SMILES C=CN1CCCC1=O.II |
| Use of | Properties Articles53 Name 1-ethenylpyrrolidin-2-one,molecular iodine Synonym More Synonyms Povidone Iodine Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection In Vivo The Dp+Povidone iodine (PVP-I) group has the second highest average score from day 13 to the end of the experimental period. The Dp+Povidone iodine and Dp+Et-OH groups also show a significantly increase in eosinophil count compare with the control group (p<0.05 and p<0.001, respectively). However, the eosinophil count does not significantly differ among the Dp+Povidone iodine (PVP-I), Dp+CHG, and Dp+vehicle groups[2]. References [1]. Zisi AP, et al. Iodine-lithium-alpha-dextrin (ILαD) against Staphylococcus aureus skin infections: a comparative study of in-vitro bactericidal activity and cytotoxicity between ILαD and povidone-iodine. J Hosp Infect. 2017 Jul 20. pii: S0195-6701(17)30395-X. [2]. Kaori Sadakane, et al. Effect of the Hand Antiseptic Agents Benzalkonium Chloride, Povidone-Iodine, Ethanol, and Chlorhexidine Gluconate on Atopic Dermatitis in NC/Nga Mice. Int J Med Sci. 2015; 12(2): 116-125. Chemical & Physical Properties Molecular Formula C6H9I2NO Exact Mass 364.877319 PSA 20.31000 LogP 2.46160 InChIKey CPKVUHPKYQGHMW-UHFFFAOYSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available If applicable, the chemical meets the requirements of the Regulations on the Safety Management of Hazardous Chemicals (adopted by the State Council on January 9, 2002). |
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