CAS Number2181-04-6
SynonymsPotassium canrenoate; Canrenoic acid potassium salt; 17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid,Potassium canrenoate; MFCD05662375; EINECS 218-554-9
Molecular FormulaC22H29KO4
Molecular Weight396.56200
Purity98%
AppearanceLight yellow to yellowish brown powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2181-04-6 |
| Catalog No. | 2A-9012086 |
| Chinese Name | 坎利酸钾 |
| Synonyms | Potassium canrenoate; Canrenoic acid potassium salt; 17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid,Potassium canrenoate; MFCD05662375; EINECS 218-554-9 |
| Molecular Formula | C22H29KO4 |
| Molecular Weight | 396.56200 |
| Purity | 98 |
| Appearance | Light yellow to yellowish brown powder |
| Storage Condition | 2-8°C |
| Application | Canrenonate (aldadiene) potassium is a canrenone-releasing prodrug and a potent competitive mineralocorticoid receptor (aldosterone receptor) antagonist. Potassium carnolate is used as a diuretic in h |
| HTC | 2916209090 |
| SMILES | CC12CCC(=O)C=C1C=CC1C2CCC2(C)C1CCC2(O)CCC(=O)[O-].[K+] |
| InChI | InChI=1S/C22H30O4.K/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25;/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25);/q;+1/p-1/t16-,17+,18+,20+,21+,22-;/m1./s1 |
| InChI Key | JTZQCHFUGHIPDF-RYVBEKKQSA-M |
| Hazard Symbols | Transport |
| MSDS | msds/12086_2_2181_04_6.pdf |
| Bioactivity | Canrenoate (Aldadiene) potassium, a prodrug that releases canrenone, is a potent, competitive mineralocorticoid receptor (aldosterone receptor) antagonist. Potassium canrenoate, as a diuretic, is used for the research of hypertension[1][2][3]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor In Vivo Potassium canrenoate has been shown to cause in rats a dose-dependent increase in myelogenous leukemia and statistically significant increases in malignant tumor of the liver, thyroid, brain and mammary gland[2][3]. Potassium canrenoate (20 mg/kg/day; drinking water) reduces isoprenaline-induced cardiac fibrosis in the rat[4]. References [1]. Iqbal J, Andrew R, et al. Displacement of cortisol from human heart by acute administration of a mineralocorticoid receptor antagonist. J Clin Endocrinol Metab. 2014;99(3):915-922. Chemical & Physical Properties Molecular Formula C22H29KO4 Molecular Weight 396.56200 Exact Mass 396.17000 PSA 77.43000 LogP 2.55550 InChIKey JTZQCHFUGHIPDF-RYVBEKKQSA-M SMILES CC12CCC(=O)C=C1C=CC1C2CCC2(C)C1CCC2(O)CCC(=O)[O-].[K+] Storage condition 2-8°C |
| Use of | Canrenoate (Aldadiene) potassium, a prodrug that releases canrenone, is a potent, competitive mineralocorticoid receptor (aldosterone receptor) antagonist. Potassium canrenoate, as a diuretic, is used for the research of hypertension[1][2][3]. Properties Articles28 Name Canrenoic Acid Potassium Salt Synonym More Synonyms Potassium canrenoate Biological Activity Description Canrenoate (Aldadiene) potassium, a prodrug that releases canrenone, is a potent, competitive mineralocorticoid receptor (aldosterone receptor) antagonist. Potassium canrenoate, as a diuretic, is used for the research of hypertension[1][2][3]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor References [1]. Iqbal J, Andrew R, et al. Displacement of cortisol from human heart by acute administration of a mineralocorticoid receptor antagonist. J Clin Endocrinol Metab. 2014;99(3):915-922. Chemical & Physical Properties Molecular Formula C22H29KO4 Exact Mass 396.17000 PSA 77.43000 LogP 2.55550 InChIKey JTZQCHFUGHIPDF-RYVBEKKQSA-M |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Imported food hygiene supervision and inspection S. Export food hygiene supervision and inspection M. Imported commodity inspection N. Exported commodity inspection |
| Transport Info | Product name: Purity: 96.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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