CAS Number6100-05-6
SynonymsMFCD00150442; EINECS 231-905-0; tripotassium,2-hydroxypropane-1,2,3-tricarboxylate,hydrate
Molecular FormulaC6H7K3O8
Molecular Weight324.41
Purity≥98 (GC/titration)%
Density1.98
Boiling Point309.6ºC at 760 mmHg
Melting Point275 °C (dec.)(lit.)
Appearancepowder
EINECS231-905-0
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6100-05-6 |
| Catalog No. | 2A-9012088 |
| Chinese Name | 柠檬酸钾,一水合物 |
| Synonyms | MFCD00150442; EINECS 231-905-0; tripotassium,2-hydroxypropane-1,2,3-tricarboxylate,hydrate |
| Molecular Formula | C6H7K3O8 |
| Molecular Weight | 324.41 |
| Purity | ≥98 (GC/titration) |
| Density | 1.98 |
| Boiling Point | 309.6ºC at 760 mmHg |
| Melting Point | 275 °C (dec.)(lit.) |
| Appearance | powder |
| Water Solubility | H2O: 1 M at 20 °C, clear, colorless |
| Storage Condition | Store at RT. |
| Application | Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the main active ingredient of Garcinia Cambogia and a derivative of citric acid. Hydroxycitric acid tripotassium hydrate can |
| EINECS | 231-905-0 |
| HTC | 2918150000 |
| PubChem ID | 24893055 |
| MDL Number | MFCD00150442 |
| SMILES | O.[K+].[K+].[K+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O |
| InChI | 1S/C6H8O7.3K.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;1H2/q;3*+1;/p-3 |
| InChI Key | PJAHUDTUZRZBKM-UHFFFAOYSA-K |
| NACRES Code | NA.25 |
| UNSPSC | 12161700 |
| Hazard Symbols | Transport |
| MSDS | msds/12088_1_6100_05_6.pdf |
| Bioactivity | Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia and a derivative of citric acid. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects[1][2][3][4]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> ATP Citrate Lyase Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Metabolic Disease In Vitro Hydroxycitric acid shows an HIF inhibitory effect compared with the control group in ARPE19 cells and 661W cells. Hydroxycitric acid can downregulate Hif1a and the downstream genes in ARPE19 cells and 661W cells. Hydroxycitric acid suppresses HIF-1α protein expression increased by CoCl2 administration in ARPE19 cells and 661W cells[2]. In chicken hepatocytes, Hydroxycitric acid decreases the accumulation of lipid droplets and accelerated energy metabolism. Hydroxycitric acid protects the cells from ER stress by increasing the antioxidant status and mitochondrial functions[2]. In Vivo Hydroxycitric acid (100-200 mg/kg) treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There is significantly less calcium oxalate crystal deposition in mice (male C57BL/6J mice) treated with Hydroxycitric acid. Hydroxycitric acid attenuates the oxidative stress induced by calcium oxalate crystallization. Hydroxycitric acid has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, and IL-6. In addition, Hydroxycitric acid alleviates tubular injury and apoptosis caused by calcium oxalate crystals[1]. The administration of Hydroxycitric acid can suppress body weight gain and fat accumulation in animals[3]. References [1]. Liu X, et al. Hydroxycitric acid inhibits renal calcium oxalate deposition by reducing oxidative stress and inflammation. Curr Mol Med. 2020 Jan 3. [2]. Ibuki M, et al. Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration. Int J Mol Sci. 2019 Oct 11;20(20). pii: E5049. [3]. Han S, et al. Hydroxycitric Acid Tripotassium Inhibits Calcium Oxalate Crystal Formation in the Drosophila Melanogaster Model of Hyperoxaluria. Med Sci Monit. 2019 May 17;25:3662-3667. [4]. Heymsfield SB, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998 Nov 11;280(18):1596-600. Chemical & Physical Properties Density 1.98 Boiling Point 309.6ºC at 760 mmHg Melting Point 275 °C (dec.)(lit.) Molecular Formula C6H7K3O8 Molecular Weight 324.410 Flash Point 155.2ºC Exact Mass 323.905212 PSA 149.85000 InChIKey PJAHUDTUZRZBKM-UHFFFAOYSA-K SMILES O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[K+].[K+].[K+] Storage condition Store at RT. Stability Stable. Incompatible with strong oxidizing agents. Water Solubility H2O: 1 M at 20 °C, clear, colorless |
| Use of | Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia and a derivative of citric acid. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects[1][2][3][4]. Properties Articles35 Name Potassium citrate monohydrate Synonym More Synonyms Hydroxycitric acid tripotassium hydrate Biological Activity Description Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia and a derivative of citric acid. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects[1][2][3][4]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> ATP Citrate Lyase Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Metabolic Disease References [1]. Liu X, et al. Hydroxycitric acid inhibits renal calcium oxalate deposition by reducing oxidative stress and inflammation. Curr Mol Med. 2020 Jan 3. [2]. Ibuki M, et al. Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration. Int J Mol Sci. 2019 Oct 11;20(20). pii: E5049. [3]. Han S, et al. Hydroxycitric Acid Tripotassium Inhibits Calcium Oxalate Crystal Formation in the Drosophila Melanogaster Model of Hyperoxaluria. Med Sci Monit. 2019 May 17;25:3662-3667. [4]. Heymsfield SB, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998 Nov 11;280(18):1596-600. Chemical & Physical Properties Molecular Formula C6H7K3O8 Exact Mass 323.905212 PSA 149.85000 InChIKey PJAHUDTUZRZBKM-UHFFFAOYSA-K SMILES O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[K+].[K+].[K+] Storage condition Store at RT. Stability Stable. Incompatible with strong oxidizing agents. |
| Tax Rebate | 13.0% |
| Supervision | 4. Export license A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods x. Export license (processing trade) y. Export license (small-scale border trade) |
| Inspection | R. Imported food hygiene supervision and inspection S. Export food hygiene supervision and inspection N. Export commodity inspection |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available The company is not responsible for any damage caused by any operation or contact with the above products. For more terms of use, see invoice or package The reverse side of the mounting strip. |
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