CAS Number52549-17-4
SynonymsMFCD00866111; Oftalar; UNII:2R7O1ET613; a-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic Acid; 2-(5H-[1]Benzopyrano[2,3-b]pyridin-7-yl)propionic Acid; 2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid; Pranoprofen; pyranoprofen; Cesflan; Y 8004; Niflan
Molecular FormulaC15H13NO3
Molecular Weight255.27
Purity≥98 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point465.7±33.0 °C at 760 mmHg
Melting Point186 °C
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 52549-17-4 |
| Catalog No. | 2A-9012100 |
| Chinese Name | 普拉洛芬 |
| Synonyms | MFCD00866111; Oftalar; UNII:2R7O1ET613; a-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic Acid; 2-(5H-[1]Benzopyrano[2,3-b]pyridin-7-yl)propionic Acid; 2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid; Pranoprofen; pyranoprofen; Cesflan; Y 8004; Niflan |
| Molecular Formula | C15H13NO3 |
| Molecular Weight | 255.27 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 465.7±33.0 °C at 760 mmHg |
| Melting Point | 186 °C |
| Appearance | powder |
| Water Solubility | Water solubility: insoluble; soluble in: dimethylf |
| Storage Condition | 0-10°C; avoid heating |
| Application | Pranoprofen is a non-steroidal anti-inflammatory compound that can treat eye diseases. |
| HTC | 2934999090 |
| PubChem ID | 329825866 |
| MDL Number | MFCD00866111 |
| SMILES | OC(C(C)C1=CC2=C(C=C1)OC3=NC=CC=C3C2)=O |
| InChI | 1S/C15H13NO3/c1-9(15(17)18)10-4-5-13-12(7-10)8-11-3-2-6-16-14(11)19-13/h2-7,9H,8H2,1H3,(H,17,18) |
| InChI Key | TVQZAMVBTVNYLA-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 41106500 |
| MSDS | msds/12100_1_52549_17_4.pdf |
| Bioactivity | Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology. Target: PGE2Pranoprofen 0.1% was found to be as effective as diclofenac sodium 0.1% in reducing inflammation and pain after strabismus surgery. Pranoprofen could be used as a safe and effective anti-inflammatory alternative for the treatment of inflammation following strabismus surgery [1]. pranoprofen has efficacy equivalent to a moderate-potency corticosteroid with a better safety profile. It should be considered for the treatment of chronic conjunctivitis of presumed nonbacterial origin [2]. Pranoprofen inhibited ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon. Moreover, pranoprofen inhibited ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor. the inhibitory effect of pranoprofen on ER stress-related genes (GRP78 and CHOP) would be mediated through the inhibition of XBP-1 splicing [3]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> PGE synthase Research Areas >> Inflammation/Immunology References [1]. Akyol-Salman, I., D. Lece-Sertoz, and O. Baykal, Topical pranoprofen 0.1% is as effective anti-inflammatory and analgesic agent as diclofenac sodium 0.1% after strabismus surgery. J Ocul Pharmacol Ther, 2007. 23(3): p. 280-3. [2]. Notivol, R., M. Martinez, and M.V. Bergamini, Treatment of chronic nonbacterial conjunctivitis with a cyclo-oxygenase inhibitor or a corticosteroid. Pranoprofen Study Group. Am J Ophthalmol, 1994. 117(5): p. 651-6. [3]. Hosoi, T., et al., Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells. Neurochem Int, 2009. 54(1): p. 1-6. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 465.7±33.0 °C at 760 mmHg Melting Point 186 °C Molecular Formula C15H13NO3 Molecular Weight 255.269 Flash Point 235.5±25.4 °C Exact Mass 255.089539 PSA 59.42000 LogP 1.74 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.628 InChIKey TVQZAMVBTVNYLA-UHFFFAOYSA-N SMILES CC(C(=O)O)c1ccc2c(c1)Cc1cccnc1O2 |
| Use of | Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology. Target: PGE2Pranoprofen 0.1% was found to be as effective as diclofenac sodium 0.1% in reducing inflammation and pain after strabismus surgery. Pranoprofen could be used as a safe and effective anti-inflammatory alternative for the treatment of inflammation following strabismus surgery [1]. pranoprofen has efficacy equivalent to a moderate-potency corticosteroid with a better safety profile. It should be considered for the treatment of chronic conjunctivitis of presumed nonbacterial origin [2]. Pranoprofen inhibited ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon. Moreover, pranoprofen inhibited ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor. the inhibitory effect of pranoprofen on ER stress-related genes (GRP78 and CHOP) would be mediated through the inhibition of XBP-1 splicing [3]. Properties Name Pranoprofen Synonym More Synonyms Pranoprofen Biological Activity Description Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology. Target: PGE2Pranoprofen 0.1% was found to be as effective as diclofenac sodium 0.1% in reducing inflammation and pain after strabismus surgery. Pranoprofen could be used as a safe and effective anti-inflammatory alternative for the treatment of inflammation following strabismus surgery [1]. pranoprofen has efficacy equivalent to a moderate-potency corticosteroid with a better safety profile. It should be considered for the treatment of chronic conjunctivitis of presumed nonbacterial origin [2]. Pranoprofen inhibited ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon. Moreover, pranoprofen inhibited ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor. the inhibitory effect of pranoprofen on ER stress-related genes (GRP78 and CHOP) would be mediated through the inhibition of XBP-1 splicing [3]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> PGE synthase Research Areas >> Inflammation/Immunology References [1]. Akyol-Salman, I., D. Lece-Sertoz, and O. Baykal, Topical pranoprofen 0.1% is as effective anti-inflammatory and analgesic agent as diclofenac sodium 0.1% after strabismus surgery. J Ocul Pharmacol Ther, 2007. 23(3): p. 280-3. [2]. Notivol, R., M. Martinez, and M.V. Bergamini, Treatment of chronic nonbacterial conjunctivitis with a cyclo-oxygenase inhibitor or a corticosteroid. Pranoprofen Study Group. Am J Ophthalmol, 1994. 117(5): p. 651-6. [3]. Hosoi, T., et al., Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells. Neurochem Int, 2009. 54(1): p. 1-6. Chemical & Physical Properties Molecular Formula C15H13NO3 Exact Mass 255.089539 PSA 59.42000 Index of Refraction 1.628 InChIKey TVQZAMVBTVNYLA-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Pramiracetam | 68497-62-1 | 2A-9012095 |
| Pramoxine hydrochloride | 637-58-1 | 2A-9012096 |
| Pranazepide | 150408-73-4 | 2A-9012097 |
| Pranidipine | 99522-79-9 | 2A-9012098 |
| Pranolium chloride | 42879-47-0 | 2A-9012099 |
| Prazosin | 19216-56-9 | 2A-9012105 |
| Prazosin hydrochloride | 19237-84-4 | 2A-9012106 |
| Prednicarbate | 73771-04-7 | 2A-9012107 |
| Pregnanolone | 128-20-1 | 2A-9012108 |
| Premerlin | 1582-09-8 | 2A-9012109 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS