CAS Number15722-48-2
SynonymsOlsalazine; 5,5'-azosalicylic acid; Azodisal; Olsalazina; Olsalazinum [Latin]; 3,3'-Azobis(6-hydroxybenzoic acid); 6,6'-Dihydroxy-3,3'-azo-di-benzoesaeure; 5,5'-Azobis(salicylic acid); 6,6'-dihydroxy-3,3'-azo-di-benzoic acid; Eriochromflavin-A; C.I. Mordant Yellow 5; Dipentum; Olsalazinum; MFCD00602469; 5-[(2Z)-2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-2-hydroxybenzoic acid; Rasal
Molecular FormulaC14H10N2O6
Molecular Weight302.246
Purity98.00%
Density1.55g/cm3
Boiling Point653.233ºC at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 15722-48-2 |
| Catalog No. | 2A-9011765 |
| Chinese Name | 奥沙拉嗪 |
| Synonyms | Olsalazine; 5,5'-azosalicylic acid; Azodisal; Olsalazina; Olsalazinum [Latin]; 3,3'-Azobis(6-hydroxybenzoic acid); 6,6'-Dihydroxy-3,3'-azo-di-benzoesaeure; 5,5'-Azobis(salicylic acid); 6,6'-dihydroxy-3,3'-azo-di-benzoic acid; Eriochromflavin-A; C.I. Mordant Yellow 5; Dipentum; Olsalazinum; MFCD00602469; 5-[(2Z)-2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-2-hydroxybenzoic acid; Rasal |
| Molecular Formula | C14H10N2O6 |
| Molecular Weight | 302.246 |
| Purity | 98.00 |
| Density | 1.55g/cm3 |
| Boiling Point | 653.233ºC at 760 mmHg |
| Storage Condition | Room temperature, sealed, dry, protected from ligh |
| Application | Olsalazine is a potent inhibitor of macrophage chemotaxis toward LTB4 with an IC50 value of 0.39 mM. It can also reduce the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and |
| HTC | 2927000090 |
| MDL Number | MFCD18429057 |
| SMILES | O=C(O)c1cc(N=Nc2ccc(O)c(C(=O)O)c2)ccc1O |
| InChI | InChI=1S/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,15,17H,(H,19,20)(H,21,22)/b16-8- |
| InChI Key | QQBDLJCYGRGAKP-UHFFFAOYSA-N |
| MSDS | msds/11765_1_15722_48_2.pdf |
| Use of | Properties Name olsalazine Synonym More Synonyms Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology References [1]. Nielsen, O.H., H.W. Verspaget, and J. Elmgreen, Inhibition of intestinal macrophage chemotaxis to leukotriene B4 by sulphasalazine, olsalazine, and 5-aminosalicylic acid. Aliment Pharmacol Ther, 1988. 2(3): p. 203-11. [2]. Horn H, et al. Modulation of arachidonic acid metabolism by olsalazine and other aminosalicylates in leukocytes. Scand J Gastroenterol. 1991 Aug;26(8):867-79. Chemical & Physical Properties Molecular Formula C14H10N2O6 Exact Mass 302.05400 PSA 139.78000 LogP 2.90960 Index of Refraction 1.678 InChIKey QQBDLJCYGRGAKP-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Benzoic acid, 3,3'-azobis(6-hydroxy- CAS REGISTRY NUMBER : 15722-48-2 LAST UPDATED : DATA ITEMS CITED : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - man DOSE/DURATION : TOXIC EFFECTS : Kidney, Ureter, Bladder - interstitial nephritis REFERENCE : AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 100,238,1996 Safety Information Hazard Codes Xi HS Code 2927000090 Precursor & DownStream Precursor 5 CAS#:89-57-6 5-Aminosalicyli... CAS#:69-72-7 Salicylic acid CAS#:119-36-8 Methyl salicylate CAS#:2516-96-3 2-Chloro-5-nitr... DownStream 1 CAS#:89-57-6 5-Aminosalicyli... |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product Name: Summary 2927000090 other diazo-, azo- or azoxy-compounds. Supervision conditions:None. VAT: 17.0%. Tax rebate rate:9.0%. MFN tariff: 6.5%. General tariff:30.0% |
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