CAS Number82419-36-1
SynonymsExocin; Floxal; Visren; Floxil; Ofloxacin; Floxin; Oflocin; hoe280; Flobacin; T666 1A M BN EV KO&&TJ DVQ HF M1 I- AT6N DNTJ D1; TARIVID; pt01; oflx; Oflox; MFCD00226105; OCUFLOX
Molecular FormulaC18H20FN3O4
Molecular Weight361.37
Purity98%
Density1.5±0.1 g/cm3
Boiling Point571.5±50.0 °C at 760 mmHg
Melting Point270-2750C
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 82419-36-1 |
| Catalog No. | 2A-9011747 |
| Chinese Name | 氧氟沙星 |
| Synonyms | Exocin; Floxal; Visren; Floxil; Ofloxacin; Floxin; Oflocin; hoe280; Flobacin; T666 1A M BN EV KO&&TJ DVQ HF M1 I- AT6N DNTJ D1; TARIVID; pt01; oflx; Oflox; MFCD00226105; OCUFLOX |
| Molecular Formula | C18H20FN3O4 |
| Molecular Weight | 361.37 |
| Purity | 98 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 571.5±50.0 °C at 760 mmHg |
| Melting Point | 270-2750C |
| Appearance | powder |
| Storage Condition | Refrigerated, airtight, dry place at 2-8°C |
| Application | Ofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase. |
| HTC | 2934999090 |
| PubChem ID | 24278613 |
| MDL Number | MFCD00226105 |
| SMILES | FC1=C(C3=[c]4[n](cc([c]([c]4=C1)=O)C(=O)O)C(CO3)C)N2CCN(CC2)C |
| InChI | 1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25) |
| InChI Key | GSDSWSVVBLHKDQ-UHFFFAOYSA-N |
| NACRES Code | NA.76 |
| UNSPSC | 51282956 |
| MSDS | msds/11747_1_82419_36_1.pdf |
| Bioactivity | Ofloxacin is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase.Target: DNA gyrase Ofloxacin is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. In vitro it has a broad spectrum of activity against aerobic Gram-negative and Gram-positive bacteria, although it is poorly active against anaerobes [1]. Ofloxacin, like other 4-quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial DNA synthesis, rather than cell wall or protein synthesis [2].Ofloxacin (20 mg/kg), norfloxacin (40 mg/kg), pefloxacin mesylate dihydrate (40 mg/kg)and ciprofloxacin (50 mg/kg) were administered by gavage twice daily for three consecutive weeks. 6 weeks after treatment, the test animals were euthanised and Achilles tendon specimens were collected. A computer monitored tensile testing machine was utilised for biomechanical testing. The mean elastic modulus of the control group was significantly higher than that of the norfloxacin and pefloxacin groups (p<0.05 and p<0.01, respectively). The mean yield force (YF) of the control group was significantly higher than those of ciprofloxacin, norfloxacin and pefloxacin groups (p<0.001, p<0.05 and p<0.01, respectively). The mean ultimate tensile force (UTF) of the control group was significantly higher than of the ciprofloxacin, norfloxacin, and pefloxacin groups (p<0.001, p<0.05 and p<0.01, respectively). Hyaline degeneration and fibre disarrangement were observed in the tendons of the ciprofloxacin, pefloxacin, and ofloxacin treated-groups, whereas myxomatous degeneration was observed only in the ciprofloxacin and pefloxacin groups [3].Clinical indications: Bacterial infection; Bacterial respiratory tract infection; Bacterial urinary tract infection Toxicity: tendinopathy; hepatotoxicity; dysglycemia Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Todd PA, et al. Ofloxacin. A reappraisal of its antimicrobial activity, pharmacology and therapeutic use. Drugs. 1991 Nov;42(5):825-76. [2]. Smith JT, et al. Ofloxacin, a bactericidal antibacterial. Chemotherapy. 1991;37 Suppl 1:2-13. [3]. Olcay E, et al. Oral toxicity of pefloxacin, norfloxacin, ofloxacin and ciprofloxacin: comparison of biomechanical and histopathological effects on Achilles tendon in rats. J Toxicol Sci. 2011 Jun;36(3):339-45. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 571.5±50.0 °C at 760 mmHg Melting Point 270-2750C Molecular Formula C18H20FN3O4 Molecular Weight 361.367 Flash Point 299.4±30.1 °C Exact Mass 361.143799 PSA 75.01000 LogP 0.84 Vapour Pressure 0.0±1.7 mmHg at 25°C Index of Refraction 1.670 InChIKey GSDSWSVVBLHKDQ-UHFFFAOYSA-N SMILES CC1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23 Storage condition 2-8°C |
| Use of | Properties Articles246 Name ofloxacin Synonym More Synonyms Ofloxacin Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Todd PA, et al. Ofloxacin. A reappraisal of its antimicrobial activity, pharmacology and therapeutic use. Drugs. 1991 Nov;42(5):825-76. [2]. Smith JT, et al. Ofloxacin, a bactericidal antibacterial. Chemotherapy. 1991;37 Suppl 1:2-13. [3]. Olcay E, et al. Oral toxicity of pefloxacin, norfloxacin, ofloxacin and ciprofloxacin: comparison of biomechanical and histopathological effects on Achilles tendon in rats. J Toxicol Sci. 2011 Jun;36(3):339-45. Chemical & Physical Properties Molecular Formula C18H20FN3O4 Exact Mass 361.143799 PSA 75.01000 Index of Refraction 1.670 InChIKey GSDSWSVVBLHKDQ-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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