| Chemical & Physical Properties | |
|---|---|
| CAS Number | 144689-63-4 |
| Catalog No. | 2A-9011759 |
| Chinese Name | 奥美沙坦酯 |
| Synonyms | Benicar; MFCD00914967; Olmetec; Benevas; Olmesartan Medoxomil |
| Molecular Formula | C29H30N6O6 |
| Molecular Weight | 558.59 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 804.2±75.0 °C at 760 mmHg |
| Melting Point | 180°C |
| Appearance | White to off-white crystalline powder |
| Storage Condition | -20°C Freezer |
| Application | Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with an IC50 of 66.2 μM. |
| HTC | 2934999090 |
| MDL Number | MFCD00944911 |
| SMILES | CCCC1=NC(C(O)(C)C)=C(C(OCC2=C(C)OC(O2)=O)=O)N1CC(C=C3)=CC=C3C4=CC=CC=C4C5=NN=NN5 |
| InChI | 1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34) |
| InChI Key | UQGKUQLKSCSZGY-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/11759_1_144689_63_4.pdf |
| Use of | Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM. Properties Name Olmesartan medoxomil Synonym More Synonyms Olmesartan medoxomil Biological Activity Description Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM. Related Catalog Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Research Areas >> Cardiovascular Disease IC50: 66.2 μM (angiotensin II receptor)[1] In Vitro Inhibition of Arachidonic acid (AA) metabolism by angiotensin II receptor blockers (ARBs) is detected in a concentration-dependent manner with IC50 of Olmesartan (66.2 μM)[1]. Olmesartan medoxomil (OLM) is a potent and selective angiotensin AT1 receptor blocker[2]. References [2]. Shah S, et al. Simultaneous Quantitative Analysis of Olmesartan Medoxomil and Amlodipine Besylate in Plasma by High-performance Liquid Chromatography Technique. J Young Pharm. 2012 Apr;4(2):88-94. Chemical & Physical Properties Molecular Formula C29H30N6O6 Exact Mass 558.222656 PSA 162.16000 Index of Refraction 1.661 InChIKey UQGKUQLKSCSZGY-UHFFFAOYSA-N Safety Information Hazard Codes Xi RIDADR NONH for all modes of transport RTECS NI4014200 HS Code 2934999090 Synthetic Route Trityl Olmesart... 144690-92-6 Olmesartan medo... 144689-63-4 Trityl Olmesart... 144690-92-6 Olmesartan medo... 144689-63-4 Ethyl 4-(2-hydr... 144690-33-5 Olmesartan medo... 144689-63-4 Literature: Sankyo Company, Limited Patent: US5616599 A1, 1997 ; US 5616599 A Precursor & DownStream Precursor 10 CAS#:144690-92-6 Trityl Olmesart... CAS#:144690-33-5 Ethyl 4-(2-hydr... CAS#:80841-78-7 4-(Chloromethyl... CAS#:1020157-01-0 Trityl Olmesart... DownStream 1 CAS#:879562-26-2 Olmesartan medo... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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