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Mildonate structure, CAS 76144-81-5

Mildonate

CAS Number76144-81-5

SynonymsDiazanium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt; MET88; Meldonium; 3-(2,2,2-Trimethyldiazan-2-ium-1-yl)propanoate; MFCD00876389; Quaterin; Mildronate; UNII-73H7UDN6EC

Molecular FormulaC6H14N2O2

Molecular Weight182.22

Purity98%

Density

Boiling Point

Melting Point85-90ºC

Flash Point

AppearanceWhite crystalline powder

EINECS

MSDSChineseEnglish

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Cat. No.: 2A-9011447 Purity: 98%
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Quality Control of [ 76144-81-5 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number76144-81-5
Catalog No.2A-9011447
Chinese Name米屈肼
SynonymsDiazanium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt; MET88; Meldonium; 3-(2,2,2-Trimethyldiazan-2-ium-1-yl)propanoate; MFCD00876389; Quaterin; Mildronate; UNII-73H7UDN6EC
Molecular FormulaC6H14N2O2
Molecular Weight182.22
Purity98
Melting Point85-90ºC
AppearanceWhite crystalline powder
Storage ConditionRefrigerator
ApplicationMildronate (Meldonium) is a cardiovascular protective drug that competitively inhibits BBOX1 and OCTN2. Mildronate (Meldonium) has an IC50 value of 34-62 μM for human recombinant BBOX and an EC50 valu
HTC2928000090
PubChem ID329831532
MDL NumberMFCD00876389
SMILESC[N+](C)(C)NCCC([O-])=O
InChI1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3
InChI KeyPVBQYTCFVWZSJK-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/11447_1_76144_81_5.pdf
Use ofMildronate (Meldonium) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes[1]. Properties Name Mildronate dihydrate Synonym More Synonyms Mildronate Biological Activity Description Mildronate (Meldonium) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease IC50: 34-62 μM (human recombinant BBOX). EC50: 21 μM (human OCTN2). References [1]. Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113(Pt B):771-780. [2]. Schobersberger W, et al. Story behind meldonium-from pharmacology to performance enhancement: a narrative review. Br J Sports Med. 2017 Jan;51(1):22-25. Chemical & Physical Properties Molecular Formula C6H14N2O2 Exact Mass 146.105530 PSA 52.16000 Index of Refraction 1.598 InChIKey PVBQYTCFVWZSJK-UHFFFAOYSA-N SMILES C[N+](C)(C)NCCC(=O)[O-] Storage condition Refrigerator Stability Hygroscopic Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Hydrazinium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, hydroxide, inner salt CAS REGISTRY NUMBER : 76144-81-5 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C6-H14-N2-O2 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya. (Izdatel'stvo Zinantne, Riga, USSR) No.1- 1970- Volume(issue)/page/year: 19,67,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya. (Izdatel'stvo Zinantne, Riga, USSR) No.1- 1970- Volume(issue)/page/year: 19,67,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya. (Izdatel'stvo Zinantne, Riga, USSR) No.1- 1970- Volume(issue)/page/year: 19,67,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2105992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2105992 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Mammal - cat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya. (Izdatel'stvo Zinantne, Riga, USSR) No.1- 1970- Volume(issue)/page/year: 19,67,1991 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes REFERENCE : EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya. (Izdatel'stvo Zinantne, Riga, USSR) No.1- 1970- Volume(issue)/page/year: 19,67,1991 Safety Information HS Code 2928000090 Precursor & DownStream Precursor 2 CAS#:76144-82-6 [(3-methoxy-3-o... CAS#:4748-96-3 ethyl 3-(2,2-di... DownStream 0
Tax Rebate9.0%
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Transport InfoProduct name: Summary 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
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