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Mifobate

Name: Mifobate
Brand: 2A Biotech
SKU: 2A-9011444

CAS Number76541-72-5

SynonymsClenicor; SR-202; Mifobate

Molecular FormulaC11H17ClO7P2

Molecular Weight358.64900

Purity90%

Density1.355g/cm3

Boiling Point436.6ºC at 760 mmHg

AppearanceWhite to off-white powder or crystal

MSDSChinese English

Cat. No.: 2A-9011444 Purity: 90%

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Quality Control of [ 76541-72-5 ] Purity: 90% SDS Specification MoL

Chemical & Physical Properties
CAS Number	76541-72-5
Catalog No.	2A-9011444
Chinese Name	米福贝特
Synonyms	Clenicor; SR-202; Mifobate
Molecular Formula	C11H17ClO7P2
Molecular Weight	358.64900
Purity	90
Density	1.355g/cm3
Boiling Point	436.6ºC at 760 mmHg
Appearance	White to off-white powder or crystal
Storage Condition	-20°C, sealed, dry
Application	Mifobate (SR-202) is a potent and specific PPARγ antagonist that selectively inhibits thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate does not affect the basal o
HTC	2931900090
SMILES	COP(=O)(OC)OC(c1ccc(Cl)cc1)P(=O)(OC)OC
InChI	InChI=1S/C11H17ClO7P2/c1-15-20(13,16-2)11(19-21(14,17-3)18-4)9-5-7-10(12)8-6-9/h5-8,11H,1-4H3
InChI Key	VQHUQHAPWMNBLP-UHFFFAOYSA-N
Bioactivity	Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects[1]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Metabolic Disease Target PPARγ:140 μM (IC50) In Vitro Mifobate (100-400 μM; pretreated with 24 hours) significantly inhibits BRL 49653- and hormone-induced adipocyte differentiation of 3T3-L1 cells in a dose-dependent manner after 6 days[1]. Mifobate is able to both interact specifically with PPARγ and inhibit its agonist-dependent interaction with the coactivator steroid receptor coactivator-1 (SRC-1). Mifobate (SR-202) inhibits TZD-stimulated recruitment of the coactivator steroid receptor coactivator-1. Mifobate blocks adipocyte differentiation induced either by thiazolidinediones or by the combination of dexamethasone, insulin, and 3-isobutyl-1-methylxanthine (IBMX)[1]. In Vivo Mifobate (400 mg/kg; Feed for 20 days) increases insulin sensitivity in ob/ob mice[1] Animal Model: Eight-week-old male ob/ob mice[1] Dosage: 400 mg/kg Administration: Feed (food admixture maintained for 20 days) Result: Prevented the time-dependent increase in glucose concentrations. References [1]. Rieusset J, et al. A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesityand antidiabetic activity. Mol Endocrinol. 2002 Nov;16(11):2628-44. Chemical & Physical Properties Density 1.355g/cm3 Boiling Point 436.6ºC at 760 mmHg Molecular Formula C11H17ClO7P2 Molecular Weight 358.64900 Flash Point 350.8ºC Exact Mass 358.01400 PSA 99.91000 LogP 4.24200 Index of Refraction 1.494 InChIKey VQHUQHAPWMNBLP-UHFFFAOYSA-N SMILES COP(=O)(OC)OC(c1ccc(Cl)cc1)P(=O)(OC)OC
Use of	Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects[1]. Properties Name [(4-chlorophenyl)-dimethoxyphosphorylmethyl] dimethyl phosphate Synonym More Synonyms SR 202 Biological Activity Description Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects[1]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Metabolic Disease PPARγ:140 μM (IC50) References [1]. Rieusset J, et al. A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesityand antidiabetic activity. Mol Endocrinol. 2002 Nov;16(11):2628-44. Chemical & Physical Properties Exact Mass 358.01400 PSA 99.91000 LogP 4.24200 Index of Refraction 1.494 InChIKey VQHUQHAPWMNBLP-UHFFFAOYSA-N
Tax Rebate	13.0%
Supervision	AB (Inbound cargo customs clearance form)
Transport Info	Product name: SR 202

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Mifobate

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