CAS Number59-92-7
Synonyms(-)-dopa; L-3,4-Dihydroxyphenylalanine; l-dop; Dopar; 3,4-Dihydroxy-L-phenylalanine; Doprin; L-4,5-Dihydroxyphenylalanine; Parda; Doparl; Beldopa; EINECS 200-445-2; 3-Hydroxytyrosine; Levopa; Bendopa; (−)-dopa; L-DOPA; MFCD00002598; L-3-(3,4-dihydroxyphenyl)-Alanine; Levodopa; Ledopa
Molecular Formula(HO)2C6H3CH2CH(NH2)CO2H
Molecular Weight197.19
Purity≥98 (TLC)%
Density1.5±0.1 g/cm3
Boiling Point448.4±45.0 °C at 760 mmHg
Melting Point276-278 °C (lit.)
Appearancepowder
EINECS200-445-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 59-92-7 |
| Catalog No. | 2A-9011171 |
| Chinese Name | 左旋多巴 |
| Synonyms | (-)-dopa; L-3,4-Dihydroxyphenylalanine; l-dop; Dopar; 3,4-Dihydroxy-L-phenylalanine; Doprin; L-4,5-Dihydroxyphenylalanine; Parda; Doparl; Beldopa; EINECS 200-445-2; 3-Hydroxytyrosine; Levopa; Bendopa; (−)-dopa; L-DOPA; MFCD00002598; L-3-(3,4-dihydroxyphenyl)-Alanine; Levodopa; Ledopa |
| Molecular Formula | (HO)2C6H3CH2CH(NH2)CO2H |
| Molecular Weight | 197.19 |
| Purity | ≥98 (TLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 448.4±45.0 °C at 760 mmHg |
| Melting Point | 276-278 °C (lit.) |
| Appearance | powder |
| Water Solubility | Water solubility: slightly soluble; insoluble: chl |
| Storage Condition | This product should be stored in a dry and dark pl |
| Application | L-DOPA is the natural form of DOPA, a dopamine precursor that can act on Parkinson's disease. |
| EINECS | 200-445-2 |
| HTC | 2932999099 |
| PubChem ID | 24277914 |
| MDL Number | MFCD00002598 |
| SMILES | N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O |
| InChI | 1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1 |
| InChI Key | WTDRDQBEARUVNC-LURJTMIESA-N |
| Beilstein/REAXYS | 2215169 |
| NACRES Code | NA.32 |
| eCl@ss | 32160406 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| MSDS | msds/11171_1_59_92_7.pdf |
| Bioactivity | L-DOPA is a natural form of DOPA used in the treatment of Parkinson's disease. L-DOPA is the precursor of dopamine and product of tyrosine hydroxylase.Target: Dopamine ReceptorL-DOPA (L-3,4-dihydroxyphenylalanine) is a chemical that is made and used as part of the normal biology of humans, some animals and plants. Some animals and humans make it via biosynthesis from the amino acid L-tyrosine. L-DOPA is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine collectively known as catecholamines. L-DOPA can be manufactured and in its pure form is sold as apsychoactive drug with the INN levodopa; trade names include Sinemet, Parcopa, Atamet, Stalevo, Madopar, Prolopa, etc. As a drug it is used in the clinical treatment of Parkinson's disease and dopamine-responsive dystonia.L-DOPA crosses the protective blood-brain barrier, whereas dopamine itself cannot. Thus, L-DOPA is used to increase dopamine concentrations in the treatment of Parkinson's disease and dopamine-responsive dystonia. This treatment was made practical and proven clinically by George Cotzias and his coworkers, for which they won the 1969 Lasker Prize. In addition, L-DOPA, co-administered with a peripheral DDCI, has been investigated as a potential treatment for restless leg syndrome. However, studieshave demonstrated "no clear picture of reduced symptoms". Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Natural Products >> Alkaloid Research Areas >> Neurological Disease Target Human Endogenous Metabolite References [1]. Hyland K, et al. Aromatic L-amino acid decarboxylase deficiency: diagnostic methodology. Clin Chem. 1992 Dec;38(12):2405-10. [2]. Merims D, et al. Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease. Parkinsonism Relat Disord. 2008;14(4):273-80. Epub 2007 Nov 7. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 448.4±45.0 °C at 760 mmHg Melting Point 276-278 °C(lit.) Molecular Formula C9H11NO4 Molecular Weight 197.188 Flash Point 225.0±28.7 °C Exact Mass 197.068802 PSA 103.78000 LogP -0.22 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.655 InChIKey WTDRDQBEARUVNC-LURJTMIESA-N SMILES NC(Cc1ccc(O)c(O)c1)C(=O)O Storage condition 2-8°C |
| Use of | Properties Articles252 Name L-dopa Synonym More Synonyms Levodopa Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Natural Products >> Alkaloid Research Areas >> Neurological Disease Human Endogenous Metabolite References [1]. Hyland K, et al. Aromatic L-amino acid decarboxylase deficiency: diagnostic methodology. Clin Chem. 1992 Dec;38(12):2405-10. [2]. Merims D, et al. Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease. Parkinsonism Relat Disord. 2008;14(4):273-80. Epub 2007 Nov 7. Chemical & Physical Properties Molecular Formula C9H11NO4 Exact Mass 197.068802 PSA 103.78000 LogP -0.22 Index of Refraction 1.655 InChIKey WTDRDQBEARUVNC-LURJTMIESA-N |
| Tax Rebate | 13.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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