CAS Number134678-17-4
Synonyms3TC; Heptodin; cent; (-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; Lamivudine; Zeffix; Zefix; Hepitec; Heptivir; 2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S); 2',3'-Dideoxy-3'-thiacytidine; Heptovir; 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one; MFCD00869739; (-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cystosine; 4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone; Epivir; 4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one; 3&L-SddC
Molecular FormulaC8H11N3O3S
Molecular Weight229.26
Purity99%
Density1.7±0.1 g/cm3
Boiling Point475.4±55.0 °C at 760 mmHg
Melting Point177 °C
AppearanceWhite crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 134678-17-4 |
| Catalog No. | 2A-9011118 |
| Chinese Name | 拉米夫定 |
| Synonyms | 3TC; Heptodin; cent; (-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; Lamivudine; Zeffix; Zefix; Hepitec; Heptivir; 2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S); 2',3'-Dideoxy-3'-thiacytidine; Heptovir; 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one; MFCD00869739; (-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cystosine; 4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone; Epivir; 4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one; 3&L-SddC |
| Molecular Formula | C8H11N3O3S |
| Molecular Weight | 229.26 |
| Purity | 99 |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 475.4±55.0 °C at 760 mmHg |
| Melting Point | 177 °C |
| Appearance | White crystalline powder |
| Water Solubility | Water solubility: soluble; water solubility: 70,00 |
| Storage Condition | Sealed and refrigerated |
| Application | Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTIs). Lamivudine inhibits HIV reverse transcriptase 1 and 2 and hepatitis B virus reverse transcriptase. |
| HTC | 2934999090 |
| PubChem ID | 329823344 |
| MDL Number | MFCD00869739 |
| SMILES | NC1=NC(=O)N(C=C1)[C@@H]2CS[C@H](CO)O2 |
| InChI | 1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1 |
| InChI Key | JTEGQNOMFQHVDC-NKWVEPMBSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/11118_1_134678_17_4.pdf |
| Bioactivity | Lamivudine is a nucleoside reverse transcriptase inhibitors?(NRTIs). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Related Catalog Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection References [1]. Li, Y.C., [A clinical study on lamivudine treatment for advanced schistosomisis with chronic B hepatits]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi, 2013. 25(5): p. 548-9, 551. [2]. Zhang, C.E., et al., [Effects of lamivudine on growth of intestinal characteristic bacteria by microcalorimetry in vitro]. Yao Xue Xue Bao, 2013. 48(10): p. 1590-4. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 475.4±55.0 °C at 760 mmHg Melting Point 177 °C Molecular Formula C8H11N3O3S Molecular Weight 229.256 Flash Point 241.3±31.5 °C Exact Mass 229.052109 PSA 115.67000 LogP -0.71 Vapour Pressure 0.0±2.7 mmHg at 25°C Index of Refraction 1.755 InChIKey JTEGQNOMFQHVDC-NKWVEPMBSA-N SMILES Nc1ccn(C2CSC(CO)O2)c(=O)n1 Storage condition Freezer |
| Use of | Properties Articles117 Name lamivudine Synonym More Synonyms Lamivudine Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection References [1]. Li, Y.C., [A clinical study on lamivudine treatment for advanced schistosomisis with chronic B hepatits]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi, 2013. 25(5): p. 548-9, 551. [2]. Zhang, C.E., et al., [Effects of lamivudine on growth of intestinal characteristic bacteria by microcalorimetry in vitro]. Yao Xue Xue Bao, 2013. 48(10): p. 1590-4. Chemical & Physical Properties Molecular Formula C8H11N3O3S Exact Mass 229.052109 PSA 115.67000 LogP -0.71 Index of Refraction 1.755 InChIKey JTEGQNOMFQHVDC-NKWVEPMBSA-N Storage condition Freezer |
| Tax Rebate | 13.0% |
| Supervision | None. Minimum tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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